In:
Natural Products and Bioprospecting, Springer Science and Business Media LLC, Vol. 13, No. 1 ( 2023-12)
Abstract:
An undescribed pyrrole acid, 1-(4′-methoxy-4′-oxobutyl)-1 H -pyrrole-2,5-dicarboxylic acid ( 1 ) and one known pyrrole acid ( 2 ) were isolated from the fruits of Phyllanthus emblica. The structures of these compounds were elucidated via the comprehensive analyses of IR, HRESIMS, 1D and 2D spectroscopic data. A series of biological assays revealed that compounds 1 and 2 could inhibit LPS-induced over-production of nitric oxide (NO), interleukin-6 (IL-6), monocyte chemotactic protein 1 (MCP-1) and tumor necrosis factor-α (TNF- α ) by reducing the phosphorylation of extracellular regulated protein kinases (ERK) and c-Jun N-terminal kinases (JNK) in RAW 264.7 cells. Additionally, compounds 1 and 2 were found to reduce lipid deposition and increase the mRNA expression of ATP-binding cassette transporter A1 in oxidized low-density lipoprotein-treated RAW264.7 macrophages. Graphical abstract
Type of Medium:
Online Resource
ISSN:
2192-2195
,
2192-2209
DOI:
10.1007/s13659-023-00393-0
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2023
detail.hit.zdb_id:
2636293-4
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