In:
International Journal of Cancer, Wiley, Vol. 140, No. 2 ( 2017-01-15), p. 329-336
Abstract:
What's new? Almost every cancer exhibits familial aggregation. Here, the authors conducted a genome‐wide complex trait analysis in Chinese participants in previous genome‐wide association studies to estimate heritability explained by single‐nucleotide polymorphisms for nine common cancers (gastric, esophageal, colorectal, lung, ovarian, hepatocellular, prostrate, breast, and nasopharyngeal). The explained heritability ranged from 10.19% to 20.26% indicating a polygenic architecture of all examined cancer types. The authors recommend performing even larger studies to better analyze the hidden heritability of each cancer type.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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