GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
Material
Publisher
Person/Organisation
Language
Years
FID
Subjects(RVK)
  • 1
    Online Resource
    Online Resource
    Inhibition of BCL11B induces downregulation of PTK7 and results in growth retardation and apoptosis in T-cell acute lymphoblastic leukemia
    Springer Science and Business Media LLC ; 2021
    In:  Biomarker Research Vol. 9, No. 1 ( 2021-12)
    Details
    In: Biomarker Research, Springer Science and Business Media LLC, Vol. 9, No. 1 ( 2021-12)
    Abstract: T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive subtype of leukemia with poor prognosis, and biomarkers and novel therapeutic targets are urgently needed for this disease. Our previous studies have found that inhibition of the B-cell leukemia/lymphoma 11B ( BCL11B ) gene could significantly promote the apoptosis and growth retardation of T-ALL cells, but the molecular mechanism underlying this effect remains unclear. This study intends to investigate genes downstream of BCL11B and further explore its function in T-ALL cells. We found that PTK7 was a potential downstream target of BCL11B in T-ALL. Compared with the healthy individuals (HIs), PTK7 was overexpressed in T-ALL cells, and BCL11B expression was positively correlated with PTK7 expression. Importantly, BCL11B knockdown reduced PTK7 expression in T-ALL cells. Similar to the effects of BCL11B silencing, downregulation of PTK7 inhibited cell proliferation and induced apoptosis in Molt-4 cells via up-regulating the expression of tumor necrosis factor (TNF)-related apoptosis-inducing ligand ( TRAIL ) and p27 . Altogether, our studies suggest that PTK7 is a potential downstream target of BCL11B , and downregulation of PTK7 expression via inhibition of the BCL11B pathway induces growth retardation and apoptosis in T-ALL cells.
    Type of Medium: Online Resource
    ISSN: 2050-7771
    URL: Article
    DOI: 10.1186/s40364-021-00270-3
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2699926-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    A Decade of Eastern Tropical Indian Ocean Observation Network (TIOON)
    American Meteorological Society ; 2021
    In:  Bulletin of the American Meteorological Society Vol. 102, No. 10 ( 2021-10), p. E2034-E2052
    Details
    In: Bulletin of the American Meteorological Society, American Meteorological Society, Vol. 102, No. 10 ( 2021-10), p. E2034-E2052
    Abstract: As an important part of the Indo-Pacific warm pool, the Indian Ocean has great significance for research on the Asian monsoon system and global climate change. From the 1960s onward, several international and regional programs have led to important new insights into the Indian Ocean. The eastern Tropical Indian Ocean Observation Network (TIOON) was established in 2010. The TIOON consists of two parts: large-scope observations and moored measurements. Large-scope observations are performed by the eastern Tropical Indian Ocean Comprehensive Experiment Cruise (TIO-CEC). Moored measurements are executed by the TIOON mooring array and the hydrological meteorological buoy. By 2019, 10 successful TIO-CEC voyages had been accomplished, making this mission the most comprehensive scientific investigation in China. The TIO-CEC voyages have collected temperature/salinity profiles, GPS radiosonde profiles, and other observations in the Indian Ocean. To supplement the existing buoy array in the Indian Ocean, an enhanced TIOON mooring array consisting of eight subthermocline acoustic Doppler current profiler (ADCP) moorings, was established since 2013. The TIOON mooring equipped with both upward-looking and downward-looking WHLS75K ADCP provide valuable current monitoring information to depth of 1,000 m in the Indian Ocean. To improve air–sea interaction monitoring, two real-time hydrological–meteorological buoys were deployed in 2019 and 2020 in the equatorial Indian Ocean. A better understanding of the Indian Ocean requires continuous and long-term observations. The TIOON program and other aspiring field investigation programs will be promoted in the future.
    Type of Medium: Online Resource
    ISSN: 0003-0007 , 1520-0477
    URL: Article
    DOI: 10.1175/BAMS-D-19-0234.1
    Language: Unknown
    Publisher: American Meteorological Society
    Publication Date: 2021
    detail.hit.zdb_id: 2029396-3
    detail.hit.zdb_id: 419957-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Compact slow-light waveguide and modulator on thin-film lithium niobate platform
    Walter de Gruyter GmbH ; 2023
    In:  Nanophotonics Vol. 12, No. 18 ( 2023-09-12), p. 3603-3611
    Details
    In: Nanophotonics, Walter de Gruyter GmbH, Vol. 12, No. 18 ( 2023-09-12), p. 3603-3611
    Abstract: Lithium niobate Mach–Zehnder modulators (MZMs) with compact footprint and fast electro-optics (EO) responses are highly demanded for the next-generation optical interconnect systems. Here, we demonstrate slow-light (SL) effect using a coupled Bragg resonator structure on the thin-film lithium niobate (TFLN) platform, and an ultra-compact SL-MZM with length L of ∼370 μm is also constructed. The fabricated SL waveguides show a large optical passband width of ∼8 nm, an insertion loss of 2.9 dB, and a maximal optical group index of 7.50, corresponding to 3.4 times as large as that of regular TFLN rib waveguide. The fabricated SL-MZM exhibits a large EO bandwidth of 〉 50 GHz in an operating wavelength band of ∼8 nm as well. High-speed OOK transmissions at data rates of 64 Gbit/s and 80 Gbit/s are successfully achieved. To our best knowledge, it is first time to build SL waveguides and compact SL-MZMs with large EO bandwidths of 〉 50 GHz on the monolithic TFLN platform.
    Type of Medium: Online Resource
    ISSN: 2192-8614
    URL: Article
    DOI: 10.1515/nanoph-2023-0306
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2023
    detail.hit.zdb_id: 2674162-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Multi-scale variability of the tropical Indian Ocean circulation system revealed by recent observations
    Springer Science and Business Media LLC ; 2018
    In:  Science China Earth Sciences Vol. 61, No. 6 ( 2018-6), p. 668-680
    Details
    In: Science China Earth Sciences, Springer Science and Business Media LLC, Vol. 61, No. 6 ( 2018-6), p. 668-680
    Type of Medium: Online Resource
    ISSN: 1674-7313 , 1869-1897
    URL: Article
    DOI: 10.1007/s11430-017-9179-x
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2018
    detail.hit.zdb_id: 2546528-4
    SSG: 6,25
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Ultra-high extinction ratio optical pulse generation with a thin film lithium niobate modulator for distributed acoustic sensing
    Optica Publishing Group ; 2024
    In:  Photonics Research Vol. 12, No. 1 ( 2024-01-01), p. 40-
    Details
    In: Photonics Research, Optica Publishing Group, Vol. 12, No. 1 ( 2024-01-01), p. 40-
    Abstract: We experimentally demonstrate ultra-high extinction ratio (ER) optical pulse modulation with an electro-optical modulator (EOM) on thin film lithium niobate (TFLN) and its application for fiber optic distributed acoustic sensing (DAS). An interface carrier effect leading to a relaxation-tail response of TFLN EOM is discovered, which can be well addressed by a small compensation component following the main driving signal. An ultra-high ER  〉  50 dB is achieved by canceling out the tailed response during pulse modulation using the EOM based on a cascaded Mach–Zehnder interferometer (MZI) structure. The modulated optical pulses are then utilized as a probe light for a DAS system, showing a sensitivity up to −62.9 dB ⋅ rad / Hz 2 (7 pε/√Hz) for 2-km single-mode sensing fiber. Spatial crosstalk suppression of 24.9 dB along the fiber is also obtained when the ER is improved from 20 dB to 50 dB, clearly revealing its importance to the sensing performance.
    Type of Medium: Online Resource
    ISSN: 2327-9125
    URL: Article
    DOI: 10.1364/PRJ.504867
    Language: English
    Publisher: Optica Publishing Group
    Publication Date: 2024
    detail.hit.zdb_id: 2724783-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Cow Dung-Based Biochar Materials Prepared via Mixed Base and Its Application in the Removal of Organic Pollutants
    MDPI AG ; 2022
    In:  International Journal of Molecular Sciences Vol. 23, No. 17 ( 2022-09-03), p. 10094-
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 23, No. 17 ( 2022-09-03), p. 10094-
    Abstract: Cow dung (CD) is a waste product of livestock production. Improper disposal of a large amount of CD will cause environmental pollution. In this work, three biochar materials based on CD (BMCD) were prepared by using three types of base, including KOH, NaOH, and mixed base (MB, a mixture of equal mass NaOH and KOH) as activators to investigate the different physicochemical properties of BMCDs (BMCD-K, BMCD-Na, and BMCD-MB). The objective was to verify the effectiveness of MB activation in the preparation of biochar materials. The results show that MB has an effect on the structural characteristics of BMCDs. In particular, the surface area and total pore volume, the specific surface area, and the total pore volume of BMCD-MB (4081.1 m2 g−1 and 3.0118 cm3 g−1) are significantly larger than those of BMCD-K (1784.6 m2 g−1 and 1.1142 cm3 g−1) and BMCD-Na (1446.1 m2 g−1 and 1.0788 cm3 g−1). While synthetic dye rhodamine B (RhB) and antibiotic tetracycline hydrochloride (TH) were selected as organic pollutant models to explore the adsorption performances, the maximum adsorption capacities of BMCD-K, BMCD-NA and BMCD-MB were 951, 770, and 1241 mg g−1 for RhB, 975, 1051, and 1105 mg g−1 for TH, respectively, which were higher than those of most adsorbents. This study demonstrated that MB can be used as an effective activator for the preparation of biochar materials with enhanced performance.
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms231710094
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2019364-6
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Breaking the bandwidth limit of a high-quality-factor ring modulator based on thin-film lithium niobate
    Optica Publishing Group ; 2022
    In:  Optica Vol. 9, No. 10 ( 2022-10-20), p. 1131-
    Details
    In: Optica, Optica Publishing Group, Vol. 9, No. 10 ( 2022-10-20), p. 1131-
    Abstract: Growing global data traffic requires high-performance modulators with a compact size, a large bandwidth, a low optical loss, and a small power consumption. A careful trade-off among these parameters usually has to be made when designing such a device. Here, we propose and demonstrate an electro-optic ring modulator on the thin-film lithium niobate platform without compromising between any performances. The device exhibits a low on-chip loss of about 0.15 dB with a high intrinsic quality-factor (Q-factor) of 7.7 × 10 5 . Since a pure coupling modulation is employed, the photon lifetime is no longer a limiting factor for the modulation speed. A large electro-optic bandwidth is obtained without any roll-off up to 67 GHz. The device, with a footprint of 3.4 m m × 0.7 m m , also exhibits a low half-wave voltage of 1.75 V, corresponding to a half-wave voltage length product of 0.35 V ⋅ c m considering the 2-mm-long modulation section. Driverless data transmission up to 240 Gb/s is also demonstrated with a peak-to-peak driving voltage of 0.75 V.
    Type of Medium: Online Resource
    ISSN: 2334-2536
    URL: Article
    DOI: 10.1364/OPTICA.470596
    Language: English
    Publisher: Optica Publishing Group
    Publication Date: 2022
    detail.hit.zdb_id: 2779175-0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Human infections and co-infections with helminths in a rural population in Guichi, Anhui Province, China
    PAGEPress Publications ; 2015
    In:  Geospatial Health Vol. 10, No. 2 ( 2015-11-04)
    Details
    In: Geospatial Health, PAGEPress Publications, Vol. 10, No. 2 ( 2015-11-04)
    Abstract: Helminth infections are believed to be common in tropical and subtropical countries. A cross-sectional study was carried out in two villages located in Guichi District in Anhui Province, the People’s Republic of China, where multiparasitism was investigated using parasitological tests. The data collected were fitted to Bayesian multi-level models to profile risk factors for helminth infections. The prevalence of 〈 em 〉 Schistosoma 〈 /em 〉 ( 〈 em 〉 S. 〈 /em 〉 ) 〈 em 〉 japonicum 〈 /em 〉 , 〈 em 〉 Ascaris 〈 /em 〉 ( 〈 em 〉 A. 〈 /em 〉 ) 〈 em 〉 lumbricoides 〈 /em 〉 and 〈 em 〉 Trichuris 〈 /em 〉 ( 〈 em 〉 T. 〈 /em 〉 ) 〈 em 〉 trichiura 〈 /em 〉 were 0.43% (range: 0-0.87% at the village level), 2.28% (range: 1.69-2.88%), and 0.21% (range: 0-0.42%), respectively. No hookworm infection was found. With regard to multiparasitism, only a 33-year-old female was found to be co-infected with 〈 em 〉 S. japonicum 〈 /em 〉 and 〈 em 〉 A. lumbricoides 〈 /em 〉 . Multiparasitism was unexpectedly rare in the study area, which contrasts with results from other studies carried out elsewhere in the country. The long-term usage of albendazole for individuals serologically positive for schistosomiasis may be the main reason, but this needs to be confirmed by future studies.
    Type of Medium: Online Resource
    ISSN: 1970-7096 , 1827-1987
    URL: Article
    DOI: 10.4081/gh.2015.374
    Language: Unknown
    Publisher: PAGEPress Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2276179-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    Strong Intraseasonal Variability of Meridional Currents near 5°N in the Eastern Indian Ocean: Characteristics and Causes
    American Meteorological Society ; 2017
    In:  Journal of Physical Oceanography Vol. 47, No. 5 ( 2017-05), p. 979-998
    Details
    In: Journal of Physical Oceanography, American Meteorological Society, Vol. 47, No. 5 ( 2017-05), p. 979-998
    Abstract: This paper reports on strong, intraseasonal, upper-ocean meridional currents observed in the Indian Ocean between the Bay of Bengal (BOB) and the equator and elucidates the underlying physical processes responsible for them. In situ measurements from a subsurface mooring at 5°N, 90.5°E reveal strong intraseasonal variability of the meridional current with an amplitude of ~0.4 m s −1 and a typical period of 30–50 days in the upper 150 m, which by far exceeds the magnitudes of the mean flow and seasonal cycle. Such prominent intraseasonal variability is, however, not seen in zonal current at the same location. Further analysis suggests that the observed intraseasonal flows are closely associated with westward-propagating eddylike sea surface height anomalies (SSHAs) along 5°N. The eddylike SSHAs are largely manifestations of symmetric Rossby waves, which result primarily from intraseasonal wind stress forcing in the equatorial waveguide and reflection of the equatorial Kelvin waves at the eastern boundary. Since the wave signals are generally symmetric about the equator, similar variability is also seen at 5°S but with weaker intensity because of the inclined coastline at the eastern boundary. The Rossby waves propagate westward, causing pronounced intraseasonal SSHA and meridional current in the upper ocean across the entire southern BOB between 84° and 94°E. They greatly weaken in the western Indian Basin, but zonal currents near the equator remain relatively strong.
    Type of Medium: Online Resource
    ISSN: 0022-3670 , 1520-0485
    URL: Article
    DOI: 10.1175/JPO-D-16-0250.1
    Language: Unknown
    Publisher: American Meteorological Society
    Publication Date: 2017
    detail.hit.zdb_id: 2042184-9
    detail.hit.zdb_id: 184162-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Observed deep energetic eddies by seamount wake
    Springer Science and Business Media LLC ; 2015
    In:  Scientific Reports Vol. 5, No. 1 ( 2015-11-30)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 5, No. 1 ( 2015-11-30)
    Abstract: Despite numerous surface eddies are observed in the ocean, deep eddies (a type of eddies which have no footprints at the sea surface) are much less reported in the literature due to the scarcity of their observation. In this letter, from recently collected current and temperature data by mooring arrays, a deep energetic and baroclinic eddy is detected in the northwestern South China Sea (SCS) with its intensity, size, polarity and structure being characterized. It remarkably deepens isotherm at deep layers by the amplitude of ~120 m and induces a maximal velocity amplitude about 0.18 m/s, which is far larger than the median velocity (0.02 m/s). The deep eddy is generated in a wake when a steering flow in the upper layer passes a seamount, induced by a surface cyclonic eddy. More observations suggest that the deep eddy should not be an episode in the area. Deep eddies significantly increase the velocity intensity and enhance the mixing in the deep ocean, also have potential implication for deep-sea sediments transport.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/srep17416
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2015
    detail.hit.zdb_id: 2615211-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...