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  • 1
    In: Physical Review B, American Physical Society (APS), Vol. 105, No. 1 ( 2022-1-31)
    Type of Medium: Online Resource
    ISSN: 2469-9950 , 2469-9969
    RVK:
    Language: English
    Publisher: American Physical Society (APS)
    Publication Date: 2022
    detail.hit.zdb_id: 2844160-6
    detail.hit.zdb_id: 209770-9
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  • 2
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2005
    In:  Journal of Central South University of Technology Vol. 12, No. S1 ( 2005-10), p. 337-342
    In: Journal of Central South University of Technology, Springer Science and Business Media LLC, Vol. 12, No. S1 ( 2005-10), p. 337-342
    Type of Medium: Online Resource
    ISSN: 1005-9784 , 1993-0666
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2005
    detail.hit.zdb_id: 2324899-3
    detail.hit.zdb_id: 2669220-X
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  • 3
    In: Human Molecular Genetics, Oxford University Press (OUP), Vol. 23, No. 7 ( 2014-04-01), p. 1923-1933
    Abstract: Aiming to identify novel genetic variants and to confirm previously identified genetic variants associated with bone mineral density (BMD), we conducted a three-stage genome-wide association (GWA) meta-analysis in 27 061 study subjects. Stage 1 meta-analyzed seven GWA samples and 11 140 subjects for BMDs at the lumbar spine, hip and femoral neck, followed by a Stage 2 in silico replication of 33 SNPs in 9258 subjects, and by a Stage 3 de novo validation of three SNPs in 6663 subjects. Combining evidence from all the stages, we have identified two novel loci that have not been reported previously at the genome-wide significance (GWS; 5.0 × 10−8) level: 14q24.2 (rs227425, P-value 3.98 × 10−13, SMOC1) in the combined sample of males and females and 21q22.13 (rs170183, P-value 4.15 × 10−9, CLDN14) in the female-specific sample. The two newly identified SNPs were also significant in the GEnetic Factors for OSteoporosis consortium (GEFOS, n = 32 960) summary results. We have also independently confirmed 13 previously reported loci at the GWS level: 1p36.12 (ZBTB40), 1p31.3 (GPR177), 4p16.3 (FGFRL1), 4q22.1 (MEPE), 5q14.3 (MEF2C), 6q25.1 (C6orf97, ESR1), 7q21.3 (FLJ42280, SHFM1), 7q31.31 (FAM3C, WNT16), 8q24.12 (TNFRSF11B), 11p15.3 (SOX6), 11q13.4 (LRP5), 13q14.11 (AKAP11) and 16q24 (FOXL1). Gene expression analysis in osteogenic cells implied potential functional association of the two candidate genes (SMOC1 and CLDN14) in bone metabolism. Our findings independently confirm previously identified biological pathways underlying bone metabolism and contribute to the discovery of novel pathways, thus providing valuable insights into the intervention and treatment of osteoporosis.
    Type of Medium: Online Resource
    ISSN: 1460-2083 , 0964-6906
    RVK:
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2014
    detail.hit.zdb_id: 1474816-2
    SSG: 12
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  • 4
    In: Acta Physica Sinica, Acta Physica Sinica, Chinese Physical Society and Institute of Physics, Chinese Academy of Sciences, Vol. 71, No. 24 ( 2022), p. 248502-
    Abstract: 〈sec〉High-performance mid-wave and long-wave infrared single-photon detectors not only have significant research value in the fields of infrared astronomy and defense technology, but also are the challenges in the field of single-photon detection technology. Superconducting nanowire single-photon detectors (SNSPDs) have shown excellent performances in the near-infrared band. However, how to further improve the cutoff wavelength 〈i〉λ〈/i〉〈sub〉c〈/sub〉 is a topic of widespread concern. In this paper, the method of improving 〈i〉λ〈/i〉〈sub〉c〈/sub〉 by regulating the superconducting disorder is discussed, and a detector with an operating wavelength band of 5–10 μm is designed and fabricated.〈/sec〉〈sec〉The studies show that the multiplication and diffusion behaviors of the quasiparticles always occur during the photon detection events, although the microscopic photodetection mechanism of SNSPD still lacks a perfect theoretical explanation. Therefore, the theoretical analysis mainly considers the influence of the quasiparticles in this paper, and the mathematical formula of the detection cutoff wavelength 〈i〉λ〈/i〉〈sub〉c〈/sub〉 can be obtained based on the phenomenological quasiparticle diffusion model. Furthermore, the disorder-dependent superconducting phase transition temperature 〈i〉T〈/i〉〈sub〉c〈/sub〉, superconducting energy gap 〈i〉Δ〈/i〉, and electron thermalization time 〈i〉τ〈/i〉〈sub〉th〈/sub〉 are also considered, in order to obtain more precise results.〈/sec〉〈sec〉Theoretical analysis suggests that the increase in the sheet resistance 〈i〉R〈/i〉〈sub〉s〈/sub〉, which evaluates the disorder strength, will help to increase 〈i〉λ〈/i〉〈sub〉c〈/sub〉. For example, when the nanowire width is kept at 30 nm and 〈i〉R〈/i〉〈sub〉s〈/sub〉 〉 380 Ω/square, it can be deduced that 〈i〉λ〈/i〉〈sub〉c〈/sub〉 is larger than 10 μm.〈/sec〉〈sec〉Experimentally, the active area of the device consists of a straight superconducting nanowire with a length of 10 μm and a width of 30 nm, so that it can effectively reduce the probability of the defects on the nanowire and avoid the current crowding effect. We fabricate a 30 nm-wide Mo〈sub〉0.8〈/sub〉Si〈sub〉0.2〈/sub〉 mid infrared SNSPD, which has a cutoff wavelength 〈i〉λ〈/i〉〈sub〉c〈/sub〉 no more than 5 μm, the effective strength of the disorder-the film sheet resistance 〈i〉R〈/i〉〈sub〉s〈/sub〉 = 248.6 Ω/square. For comparison, the sheet resistance, which is controlled by the film thickness, increases to about 320 Ω/square in this experiment.〈/sec〉〈sec〉It is demonstrated that the Mo〈sub〉0.8〈/sub〉Si〈sub〉0.2〈/sub〉 detector with 〈i〉R〈/i〉〈sub〉s 〈inline-formula〉〈tex-math id="Z-20221216014812-1"〉\begin{document}$ \sim $\end{document}〈/tex-math〉〈alternatives〉〈graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="24-20221594_Z-20221216014812-1.jpg"/〉〈graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="24-20221594_Z-20221216014812-1.png"/〉〈/alternatives〉〈/inline-formula〉〈/sub〉320 Ω/square can achieve saturated quantum efficiency at a wavelength of 6 μm. Furthermore, 53% quantum efficiency at a wavelength of 10.2 μm can be obtained when the detector works at a bias current of 0.9〈i〉I〈/i〉〈sub〉SW〈/sub〉 (〈i〉I〈/i〉〈sub〉SW〈/sub〉 is the superconducting transition current), and it can theoretically reach a maximum value of 92% if the compression of switching current is excluded. Therefore, it can be predicted that the disorder regulation may become another efficient approach to designing high-performance mid-wave and long-wave infrared SNSPDs, in addition to the optimization of the superconducting energy gap and the cross section of superconducting nanowire.〈/sec〉〈sec〉However, the continuous increase in the disorder will cause both the superconducting phase transition temperature 〈i〉T〈/i〉〈sub〉c〈/sub〉 and 〈i〉I〈/i〉〈sub〉SW〈/sub〉 of the detector to decrease from the viewpoint of detector fabrication and application. This downward trend is especially pronounced when the nanowire width is ultranarrow, which is not conducive to the signal readout of the detector. Thus, exploring the optimal disorder regulation technology and balancing the relationship among the operating temperature, the signal-to-noise ratio, and the cutoff wavelength will have key scientific and application value for the development of high-performance mid-wave and long-wave infrared SNSPDs.〈/sec〉
    Type of Medium: Online Resource
    ISSN: 1000-3290 , 1000-3290
    Language: Unknown
    Publisher: Acta Physica Sinica, Chinese Physical Society and Institute of Physics, Chinese Academy of Sciences
    Publication Date: 2022
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  • 5
    In: Acta Physica Sinica, Acta Physica Sinica, Chinese Physical Society and Institute of Physics, Chinese Academy of Sciences, Vol. 0, No. 0 ( 2023), p. 0-
    Abstract: High-performance mid-wave and long-wave infrared single-photon detectors not only have significant research value in the fields of infrared astronomy and defense technology, but are also challenging to be realized in the field of single-photon detection technology. Superconducting nanowire single-photon detectors (SNSPDs) have shown excellent performance in the near-infrared band. However, how to further improve the cutoff wavelength 〈i〉λ〈/i〉〈sub〉c〈/sub〉 is a topic of widespread concern. In this paper, the method for improving 〈i〉λ〈/i〉〈sub〉c〈/sub〉 by applying the regulation of the superconducting disorder is discussed, and a detector with an operating wavelength band of 5 - 10 μm is designed and fabricated. 〈br〉Studies have shown that the multiplication and diffusion behaviors of the quasiparticles always occur during the photon detection events, although the microscopic photodetection mechanism of SNSPD still lacks a perfect theoretical explanation. Therefore, the theoretical analysis mainly considers the influence of the quasiparticles in this paper, and the mathematical formula of the detection cutoff wavelength 〈i〉λ〈/i〉〈sub〉c〈/sub〉 can be obtained based on the phenomenological quasiparticle diffusion model. Furthermore, the disorder-dependent superconducting phase transition temperature 〈i〉T〈/i〉〈sub〉c〈/sub〉, superconducting energy gap 〈i〉〈teshuzifu〉D〈/i〉, and electron thermalization time 〈i〉τ〈/i〉〈sub〉th〈/sub〉 are also considered, in order to get more precise results.〈br〉Theoretical analysis suggests that the increase in the sheet resistance 〈i〉R〈/i〉〈sub〉s〈/sub〉, which evaluates the disorder strength, will help to increase 〈i〉λ〈/i〉〈sub〉c〈/sub〉. For example, when the nanowire width is kept at 30 nm and 〈i〉R〈/i〉〈sub〉s〈/sub〉 〉 380 Ω/□, it can be deduced that 〈i〉λ〈/i〉〈sub〉c〈/sub〉 is larger than 10 μm.〈br〉Experimentally, the active area of the device consists of a straight superconducting nanowire with a length of 10 μm and a width of 30 nm, so that it can effectively reduce the probability of the defects on the nanowire and avoid the current crowding effect. We have fabricated a 30 nm-wide Mo〈sub〉0.8〈/sub〉Si〈sub〉0.2〈/sub〉 mid infrared SNSPD, which has a cutoff wavelength 〈i〉λ〈/i〉〈sub〉c〈/sub〉 no more than 5 μm, the effective strength of the disorder - the film sheet resistance 〈i〉R〈/i〉〈sub〉s〈/sub〉 = 248.6 Ω/□. As a comparison, the sheet resistance, which is controlled by the film thickness, is increased to about 320 Ω/□ in this experiment.〈br〉It is demonstrated that the Mo〈sub〉0.8〈/sub〉Si〈sub〉0.2〈/sub〉 detector with 〈i〉R〈/i〉〈sub〉s〈/sub〉 ~320 Ω/□ can achieve saturated quantum efficiency at a wavelength of 6 μm. Furthermore, 53% quantum efficiency at the wavelength of 10.2 μm can be obtained when the detector works at a bias current of 0.9 〈i〉I〈/i〉〈sub〉SW〈/sub〉 (〈i〉I〈/i〉〈sub〉SW〈/sub〉 is the superconducting transition current), and it can theoretically reach a maximum value of 92% if the compression of switching current is excluded. Therefore, it can be predicted that the disorder regulation may become another efficient approach for designing high-performance mid-wave and long-wave infrared SNSPDs, in addition to the optimization of the superconducting energy gap and the cross section of superconducting nanowire.〈br〉However, the continuous increase in the disorder will cause a decrease in both the superconducting phase transition temperature 〈i〉T〈/i〉〈sub〉c〈/sub〉 and 〈i〉I〈/i〉〈sub〉SW〈/sub〉 of the detector from the point of detector fabrication and application. This downward trend is especially pronounced when the nanowire width is ultranarrow, which is not conducive to the signal readout of the detector. Thus, exploring the optimal disorder regulation technology and balancing the relationship between the operating temperature, the signal-to-noise ratio, and the cutoff wavelength will have key scientific and application value for the development of high-performance mid-wave and long-wave infrared SNSPDs.
    Type of Medium: Online Resource
    ISSN: 1000-3290 , 1000-3290
    Language: Unknown
    Publisher: Acta Physica Sinica, Chinese Physical Society and Institute of Physics, Chinese Academy of Sciences
    Publication Date: 2023
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  • 6
    Online Resource
    Online Resource
    Baishideng Publishing Group Inc. ; 2021
    In:  World Journal of Clinical Cases Vol. 9, No. 30 ( 2021-10-26), p. 8985-8998
    In: World Journal of Clinical Cases, Baishideng Publishing Group Inc., Vol. 9, No. 30 ( 2021-10-26), p. 8985-8998
    Type of Medium: Online Resource
    ISSN: 2307-8960
    Language: Unknown
    Publisher: Baishideng Publishing Group Inc.
    Publication Date: 2021
    detail.hit.zdb_id: 2864414-1
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  • 7
    Online Resource
    Online Resource
    Baishideng Publishing Group Inc. ; 2023
    In:  World Journal of Stem Cells Vol. 15, No. 6 ( 2023-6-26), p. 561-575
    In: World Journal of Stem Cells, Baishideng Publishing Group Inc., Vol. 15, No. 6 ( 2023-6-26), p. 561-575
    Type of Medium: Online Resource
    ISSN: 1948-0210
    Language: Unknown
    Publisher: Baishideng Publishing Group Inc.
    Publication Date: 2023
    detail.hit.zdb_id: 2583482-4
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  • 8
    In: Atmosphere, MDPI AG, Vol. 13, No. 5 ( 2022-05-13), p. 793-
    Abstract: Nitrogen oxides released from the combustion of fossil fuels are one of the main air pollutants. Selective catalytic reduction technology is the most widely used nitrogen oxide removal technology in the industry. With the development of nanomaterials science, more and more novel nanomaterials are being used as catalysts for the selective reduction of nitrogen oxides. In recent years, metal-organic frameworks (MOFs), with large specific surface areas and abundant acid and metal sites, have been extensively studied in the selective catalytic reduction of nitrogen oxides. This review summarizes recent progress in monometallic MOFs, bimetallic MOFs, and MOF-derived catalysts for the selective catalytic reduction of nitrogen oxides and compares the reaction mechanisms of different catalysts. This article also suggests the advantages and disadvantages of MOF-based catalysts compared with traditional catalysts and points out promising research directions in this field.
    Type of Medium: Online Resource
    ISSN: 2073-4433
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2605928-9
    SSG: 23
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  • 9
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 7, No. 1 ( 2017-03-17)
    Abstract: In the nervous system, excessive activation of NMDA receptors causes neuronal injury. Although activation of NMDARs has been proposed to contribute to the progress of diabetes, little is known about the effect of excessive long-term activation of NMDARs on β-cells, especially under the challenge of hyperglycemia. Here we thoroughly investigated whether endogenous glutamate aggravated β-cell dysfunction under chronic exposure to high-glucose via activation of NMDARs. The glutamate level was increased in plasma of diabetic mice or patients and in the supernatant of β-cell lines after treatment with high-glucose for 72 h. Decomposing the released glutamate improved GSIS of β-cells under chronic high-glucose exposure. Long-term treatment of β-cells with NMDA inhibited cell viability and decreased GSIS. These effects were eliminated by GluN1 knockout. The NMDAR antagonist MK-801 or GluN1 knockout prevented high-glucose-induced dysfunction in β-cells. MK-801 also decreased the expression of pro-inflammatory cytokines, and inhibited I-κB degradation, ROS generation and NLRP3 inflammasome expression in β-cells exposed to high-glucose. Furthermore, another NMDAR antagonist, Memantine, improved β-cells function in diabetic mice. Taken together, these findings indicate that an increase of glutamate may contribute to the development of diabetes through excessive activation of NMDARs in β-cells, accelerating β-cells dysfunction and apoptosis induced by hyperglycemia.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2017
    detail.hit.zdb_id: 2615211-3
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  • 10
    In: Frontiers in Cell and Developmental Biology, Frontiers Media SA, Vol. 9 ( 2021-9-23)
    Abstract: Ovarian cancer (OC) is the leading cause of cancer-related death among all gynecological tumors. N6-methyladenosine (m6A)-related regulators play essential roles in various tumors, including OC. However, the expression of m6A RNA methylation regulators and the related regulatory network in OC and their correlations with prognosis remain largely unknown. In the current study, we obtained the genome datasets of OC from GDC and GTEx database and analyzed the mRNA levels of 21 key m6A regulators in OC and normal human ovarian tissues. The expression levels of 7 m6A regulators were lower in both the OC tissues and the high-stage group. Notably, the 5-year survival rate of patients with OC presenting low VIRMA expression or high HNRNPA2B1 expression was higher than that of the controls. Next, a risk score model based on the three selected m6A regulators (VIRMA, IGF2BP1, and HNRNPA2B1) was built by performing a LASSO regression analysis, and the moderate accuracy of the risk score model to predict the prognosis of patients with OC was examined by performing ROC curve, nomogram, and univariate and multivariate Cox regression analyses. In addition, a regulatory network of miRNAs-m6A regulators-m6A target genes, including 2 miRNAs, 3 m6A regulators, and 47 mRNAs, was constructed, and one of the pathways, namely, miR-196b-5p-IGF2BP1-PTEN, was initially validated based on bioinformatic analysis and assay verification. These results demonstrated that the risk score model composed of three m6A RNA methylation regulators and the related network of miRNAs-m6A regulators-m6A target genes is valuable for predicting the prognosis of patients with OC, and these molecules may serve as potential biomarkers or therapeutic targets in the future.
    Type of Medium: Online Resource
    ISSN: 2296-634X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2737824-X
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