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  • 1
    Online Resource
    Online Resource
    Discussion and Application of WPKITechnology
    Canadian Center of Science and Education ; 2007
    In:  Modern Applied Science Vol. 1, No. 4 ( 2007-12-19)
    Details
    In: Modern Applied Science, Canadian Center of Science and Education, Vol. 1, No. 4 ( 2007-12-19)
    Type of Medium: Online Resource
    ISSN: 1913-1852 , 1913-1844
    URL: Article
    DOI: 10.5539/mas.v1n4p50
    Language: Unknown
    Publisher: Canadian Center of Science and Education
    Publication Date: 2007
    detail.hit.zdb_id: 2436317-0
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  • 2
    Online Resource
    Online Resource
    Impact of Evidence‐Based Stroke Care on Patient Outcomes: A Multilevel Analysis of an International Study
    Ovid Technologies (Wolters Kluwer Health) ; 2019
    In:  Journal of the American Heart Association Vol. 8, No. 13 ( 2019-07-02)
    Details
    In: Journal of the American Heart Association, Ovid Technologies (Wolters Kluwer Health), Vol. 8, No. 13 ( 2019-07-02)
    Abstract: The uptake of proven stroke treatments varies widely. We aimed to determine the association of evidence‐based processes of care for acute ischemic stroke ( AIS ) and clinical outcome of patients who participated in the HEADPOST (Head Positioning in Acute Stroke Trial), a multicenter cluster crossover trial of lying flat versus sitting up, head positioning in acute stroke. Methods and Results Use of 8 AIS processes of care were considered: reperfusion therapy in eligible patients; acute stroke unit care; antihypertensive, antiplatelet, statin, and anticoagulation for atrial fibrillation; dysphagia assessment; and physiotherapist review. Hierarchical, mixed, logistic regression models were performed to determine associations with good outcome (modified Rankin Scale scores 0–2) at 90 days, adjusted for patient and hospital variables. Among 9485 patients with AIS, implementation of all processes of care in eligible patients, or “defect‐free” care, was associated with improved outcome (odds ratio, 1.40; 95% CI, 1.18–1.65) and better survival (odds ratio, 2.23; 95% CI , 1.62–3.09). Defect‐free stroke care was also significantly associated with excellent outcome (modified Rankin Scale score 0–1) (odds ratio, 1.22; 95% CI , 1.04–1.43). No hospital characteristic was independently predictive of outcome. Only 1445 (15%) of eligible patients with AIS received all processes of care, with significant regional variations in overall and individual rates. Conclusions Use of evidence‐based care is associated with improved clinical outcome in AIS . Strategies are required to address regional variation in the use of proven AIS treatments. Clinical Trial Registration URL : https://www.clinicaltrials.gov . Unique Identifier: NCT 02162017.
    Type of Medium: Online Resource
    ISSN: 2047-9980
    URL: Article
    DOI: 10.1161/JAHA.119.012640
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2019
    detail.hit.zdb_id: 2653953-6
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  • 3
    Online Resource
    Online Resource
    An invasive zone in human liver cancer identified by Stereo-seq promotes hepatocyte–tumor cell crosstalk, local immunosuppression and tumor progression
    Springer Science and Business Media LLC ; 2023
    In:  Cell Research Vol. 33, No. 8 ( 2023-06-19), p. 585-603
    Details
    In: Cell Research, Springer Science and Business Media LLC, Vol. 33, No. 8 ( 2023-06-19), p. 585-603
    Abstract: Dissecting and understanding the cancer ecosystem, especially that around the tumor margins, which have strong implications for tumor cell infiltration and invasion, are essential for exploring the mechanisms of tumor metastasis and developing effective new treatments. Using a novel tumor border scanning and digitization model enabled by nanoscale resolution-SpaTial Enhanced REsolution Omics-sequencing (Stereo-seq), we identified a 500 µm-wide zone centered around the tumor border in patients with liver cancer, referred to as “the invasive zone”. We detected strong immunosuppression, metabolic reprogramming, and severely damaged hepatocytes in this zone. We also identified a subpopulation of damaged hepatocytes with increased expression of serum amyloid A1 and A2 (referred to collectively as SAAs) located close to the border on the paratumor side. Overexpression of CXCL6 in adjacent malignant cells could induce activation of the JAK-STAT3 pathway in nearby hepatocytes, which subsequently caused SAAs’ overexpression in these hepatocytes. Furthermore, overexpression and secretion of SAAs by hepatocytes in the invasive zone could lead to the recruitment of macrophages and M2 polarization, further promoting local immunosuppression, potentially resulting in tumor progression. Clinical association analysis in additional five independent cohorts of patients with primary and secondary liver cancer ( n  = 423) showed that patients with overexpression of SAAs in the invasive zone had a worse prognosis. Further in vivo experiments using mouse liver tumor models in situ confirmed that the knockdown of genes encoding SAAs in hepatocytes decreased macrophage accumulation around the tumor border and delayed tumor growth. The identification and characterization of a novel invasive zone in human cancer patients not only add an important layer of understanding regarding the mechanisms of tumor invasion and metastasis, but may also pave the way for developing novel therapeutic strategies for advanced liver cancer and other solid tumors.
    Type of Medium: Online Resource
    ISSN: 1748-7838
    URL: Article
    DOI: 10.1038/s41422-023-00831-1
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2082402-6
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  • 4
    Online Resource
    Online Resource
    Spatially resolved gene regulatory and disease-related vulnerability map of the adult Macaque cortex
    Springer Science and Business Media LLC ; 2022
    In:  Nature Communications Vol. 13, No. 1 ( 2022-11-08)
    Details
    In: Nature Communications, Springer Science and Business Media LLC, Vol. 13, No. 1 ( 2022-11-08)
    Abstract: Single cell approaches have increased our knowledge about the cell type composition of the non-human primate (NHP), but a detailed characterization of area-specific regulatory features remains outstanding. We generated single-cell transcriptomic and chromatin accessibility (single-cell ATAC) data of 358,237 cells from prefrontal cortex (PFC), primary motor cortex (M1) and primary visual cortex (V1) of adult female cynomolgus monkey brain, and integrated this dataset with Stereo-seq (spatial enhanced resolution omics-sequencing) of the corresponding cortical areas to assign topographic information to molecular states. We identified area-specific chromatin accessible sites and their targeted genes, including the cell type-specific transcriptional regulatory network associated with excitatory neurons heterogeneity. We reveal calcium ion transport and axon guidance genes related to specialized functions of PFC and M1, identified the similarities and differences between adult macaque and human oligodendrocyte trajectories, and mapped the genetic variants and gene perturbations of human diseases to NHP cortical cells. This resource establishes a transcriptomic and chromatin accessibility combinatory regulatory landscape at a single-cell and spatially resolved resolution in NHP cortex.
    Type of Medium: Online Resource
    ISSN: 2041-1723
    URL: Article
    DOI: 10.1038/s41467-022-34413-3
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2553671-0
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  • 5
    Online Resource
    Online Resource
    Development of a risk score for colorectal cancer in Chinese males: A prospective cohort study
    Wiley ; 2020
    In:  Cancer Medicine Vol. 9, No. 2 ( 2020-01), p. 816-823
    Details
    In: Cancer Medicine, Wiley, Vol. 9, No. 2 ( 2020-01), p. 816-823
    Abstract: To build a simple predictive model as a guide to stratify average‐risk population for colonoscopy examinations. We collected data from 92 923 males without a prior history of cancer enrolled in the Kailuan Cohort Study of China. Risk factors included in the evaluation of colorectal cancer (CRC) were collected by questionnaire‐based interviews at the baseline. Logistic regression coefficients for incident CRC predictors were converted into risk scores by the absolute value of the smallest coefficient in the model and rounding up to the nearest integer. Receiver operating characteristic (ROC) analysis with the leave‐one‐out cross‐validation method was applied to evaluate model performance. In the 10‐year follow‐up, 353 CRC patients were in the cohort. Age, alcohol consumption, waist circumference, occupational sitting time, and history of diabetes were selected for the scoring system, and the adjusted area under the ROC was 0.66. Population in the highest risk group (16‐19 points) had a 33.12‐fold (95% CI: 13.44‐81.59) higher risk of CRC than those in the lowest risk group. When we defined 13 points as the cut‐off, the sensitivity and specificity of the scoring system for CRC were 67.99% and 62.42%, respectively. A simple scoring system for CRC has been developed to identify men at an increased relative risk of CRC within 10 years using several well‐established risk factors, which allows selection of asymptomatic candidates for priority of CRC screening and saving the health resource in cancer prevention and control.
    Type of Medium: Online Resource
    ISSN: 2045-7634 , 2045-7634
    URL: Issue
    URL: Article
    DOI: 10.1002/cam4.v9.2
    DOI: 10.1002/cam4.2734
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2659751-2
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  • 6
    Online Resource
    Online Resource
    The association between fasting blood glucose trajectory and cancer risk in Chinese population without diabetes
    Wiley ; 2020
    In:  International Journal of Cancer Vol. 147, No. 4 ( 2020-08-15), p. 958-966
    Details
    In: International Journal of Cancer, Wiley, Vol. 147, No. 4 ( 2020-08-15), p. 958-966
    Abstract: What's new? Impaired fasting blood glucose (IFG) is associated with an increased risk of cancer. In China, lifestyle changes have significantly increased the prevalence of IFG. But are high fasting blood‐glucose (FBG) levels the only culprit in increased cancer risk? In this study, the authors found that people with initially low FBG that rose over time (the “FBG trajectory”) also had an increased risk both for overall cancer and especially for gastrointestinal cancer. BMI may modify these associations. A deeper understanding of these phenomena may improve future prevention strategies.
    Type of Medium: Online Resource
    ISSN: 0020-7136 , 1097-0215
    URL: Issue
    URL: Article
    DOI: 10.1002/ijc.v147.4
    DOI: 10.1002/ijc.32858
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 218257-9
    detail.hit.zdb_id: 1474822-8
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  • 7
    Online Resource
    Online Resource
    Danggui Buxue Decoction, a Classical Formula of Traditional Chinese Medicine, Fails to Prevent Myelosuppression in Breast Cancer Patients Treated With Adjuvant Chemotherapy: A Prospective Study
    SAGE Publications ; 2017
    In:  Integrative Cancer Therapies Vol. 16, No. 3 ( 2017-09), p. 406-413
    Details
    In: Integrative Cancer Therapies, SAGE Publications, Vol. 16, No. 3 ( 2017-09), p. 406-413
    Abstract: Danggui Buxue Decoction (DBD), a classical formula of traditional Chinese medicine (TCM), has an impact on promoting hematopoiesis. The aim of our study was to determine whether DBD can prevent myelosuppression in breast cancer patients treated with adjuvant chemotherapy. We conducted a phase II randomized prospective controlled clinical study. From December 2013 to February 2015, 106 patients were enrolled and randomly assigned (1:1) to the TCM group and control group. The primary end point was incidence of grade 3-4 neutropenia. The secondary end points included incidence of grade 3-4 neutropenia in each cycle, incidence of anemia, and incidence of thrombopenia during 4 cycles. Seventeen patients withdrew from this study, and 89 patients were included in the final analysis. Incidences of grade 3-4 neutropenia during 4 cycles were 57.1% in the TCM group and 59.6% in the control group, and there was no significant difference ( P = .816). Similarly, no significant differences were observed between the 2 groups for incidence of grade 3-4 neutropenia in each cycle. While incidences of anemia were 54.8% and 66.6% for the TCM group and control group, respectively ( P = .280), incidences of thrombopenia were 11.9% for the TCM group and 4.3% for the control group ( P = .248). No significant differences were observed for the incidence of other nonhematological toxicities between the 2 groups. DBD failed to prevent myelosuppression in breast cancer patients treated with adjuvant chemotherapy. Further studies are warranted to validate the efficacy of DBD in selected patients.
    Type of Medium: Online Resource
    ISSN: 1534-7354 , 1552-695X
    URL: Article
    DOI: 10.1177/1534735416675952
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2101248-9
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  • 8
    Online Resource
    Online Resource
    Monocytic MDSCs skew Th17 cells toward a pro-osteoclastogenic phenotype and potentiate bone erosion in rheumatoid arthritis
    Oxford University Press (OUP) ; 2021
    In:  Rheumatology Vol. 60, No. 5 ( 2021-05-14), p. 2409-2420
    Details
    In: Rheumatology, Oxford University Press (OUP), Vol. 60, No. 5 ( 2021-05-14), p. 2409-2420
    Abstract: While myeloid-derived suppressor cells (MDSCs) were previously shown to promote a proinflammatory T helper (Th) 17 response in autoimmune conditions, a potential impact of the MDSC-Th17 immune axis on abnormal bone destruction in RA remains largely unknown. Methods We investigated the correlation between the frequency of MDSCs or its subsets and joint destruction in RA patients. The reciprocal actions of patient-derived MDSCs and Th17 cells were studied using osteoclast (OC) differentiation and bone resorption assays in vitro, which were further validated using mouse models of RA. Contribution of MDSCs to osteoclastogenesis and bone erosion in vivo was determined by depletion or transfer of MDSCs. Results Human MDSCs, particularly monocytic MDSCs (M-MDSCs), exhibit inherent OC-differentiating capacity and positively correlate with clinical bone erosion in RA patients. Strikingly, patient-derived M-MDSCs can program Th17 cells towards a pro-osteoclastogenic phenotype, which in return potentiates OC differentiation via the receptor activator of nuclear factor κΒ ligand (RANK-L)-RANK signalling. This enhanced osteolysis driven by the reciprocal actions of M-MDSCs and Th17 cells is further confirmed using mouse models of RA. Selective depletion of M-MDSCs significantly ameliorates osteoclastogenesis and disease severity in arthritic mice, whereas transfer of M-MDSCs aggravates bone erosion associated with increased OCs in recipient mice. Conclusion Our findings highlight the functional plasticity of MDSCs and identify a novel pro-osteoclastogenic pathway governed by interplay between myeloid cells and T lymphocytes in autoimmune RA.
    Type of Medium: Online Resource
    ISSN: 1462-0324 , 1462-0332
    URL: Article
    DOI: 10.1093/rheumatology/keaa625
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2021
    detail.hit.zdb_id: 1474143-X
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  • 9
    Online Resource
    Online Resource
    External forcing mechanisms controlling the Qiongdong upwelling in the northern South China Sea during the Holocene
    Elsevier BV ; 2023
    In:  Global and Planetary Change Vol. 220 ( 2023-01), p. 104021-
    Details
    In: Global and Planetary Change, Elsevier BV, Vol. 220 ( 2023-01), p. 104021-
    Type of Medium: Online Resource
    ISSN: 0921-8181
    URL: Article
    DOI: 10.1016/j.gloplacha.2022.104021
    RVK:
    RA 1000
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 20361-0
    detail.hit.zdb_id: 2016967-X
    SSG: 13
    SSG: 14
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  • 10
    Online Resource
    Online Resource
    Changes in hydrodynamics and nutrient load of the coastal bay induced by Typhoon Talim (2023)
    Frontiers Media SA ; 2024
    In:  Frontiers in Marine Science Vol. 11 ( 2024-3-27)
    Details
    In: Frontiers in Marine Science, Frontiers Media SA, Vol. 11 ( 2024-3-27)
    Abstract: Typhoons can greatly alter the hydrodynamic and nutrient supply in coastal oceans. However, due to the complex conditions of typhoons, such as their intensity, even slight changes may cause substantial changes in hydrodynamics and nutrient supply, which needs to be better understood. In this study, we conducted two cruises before and after Typhoon Talim (2023) to quantitatively investigate changes in hydrodynamics and nutrient supply in Zhanjiang Bay using dual water isotopes. Before the typhoon, strong stratification occurred in the bay. However, the strong external force of the typhoon destroyed the stratification and substantially changed the water mixing in the bay after the typhoon. In the upper bay, massive freshwater input remarkably decreased the salinity during the post-typhoon period (freshwater increased by 18%). In contrast, the salinity variation in the lower bay was minimal, mainly due to massive seawater intrusion from the outer bay induced by the typhoon; the seawater mixed with freshwater columns from the upper bay, forming a strong ocean front. The intensity of ocean fronts induced by typhoons directly depended on the typhoon intensity landing in Zhanjiang Bay, as stronger typhoons will cause more intrusion of high-salinity seawater from the outer bay. Due to the formation of the ocean front, freshwater and terrestrial nutrients from the upper bay are prevented from being transported downwards, resulting in a large amount of accumulated pollutants within the bay. By contrast, due to the impact of high-salinity seawater intrusion, the contribution of seawater from the outer bay has increased, thereby diluting the nutrients in the lower bay. This study provides a new insight into the responses of coastal marine eco-environment systems to typhoons.
    Type of Medium: Online Resource
    ISSN: 2296-7745
    URL: Article
    DOI: 10.3389/fmars.2024.1383528
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2024
    detail.hit.zdb_id: 2757748-X
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