In:
The EMBO Journal, EMBO, Vol. 33, No. 23 ( 2014-12), p. 2745-2764
Abstract:
image Super‐resolution microscopy reveals how nanoscale organization of F‐actin regulators correlates with changes in neuronal dendritic spine morphology. Branched F‐actin nucleation occurs at the vicinity of the postsynapse density, while elongation occurs at the tip of finger‐like protrusions. Spine morphing and motility are supported by finger‐like protrusions. Actin elongators, VASP and FMNL 2, move outwards from the PSD with membrane protrusion tips. The PSD is a persistent confinement zone for IRS p53 and the WAVE complex, being an organization center of branched F‐actin nucleation. Actin elongation from immobile Arp2/3 close to the PSD is not generating a concerted fast rearward flow of Arp2/3 and F‐actin in spines. Dendritic spine enlargement induced by long‐lasting enhancement of Rac1 or Shank3 functions is associated with delocalization of the WAVE complex from the PSD .
Type of Medium:
Online Resource
ISSN:
0261-4189
,
1460-2075
DOI:
10.15252/embj.201488837
Language:
English
Publisher:
EMBO
Publication Date:
2014
detail.hit.zdb_id:
1467419-1
detail.hit.zdb_id:
586044-1
SSG:
12
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