In:
International Journal of Cancer, Wiley, Vol. 139, No. 9 ( 2016-11), p. 2033-2046
Abstract:
What's new? Secondary fungal metabolites known as mycotoxins occur in food and air, making oral ingestion and inhalation significant routes of mycotoxicoses. Topical exposure, however, can also result in toxicity, and several mycotoxins, including deoxynivalenol (DON), are capable of penetrating through the skin. DON is also potentially genotoxic and tumor‐promoting. In this study, topical exposure to DON was found to induce superoxide and hydroxyl radical generation, enhance DNA damage and apoptosis, and initiate tumor formation in mouse skin. The findings may be of relevance in assessing the health risks of DON dermal exposure, especially among farmers working in agricultural fields.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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