In:
The American Journal of Chinese Medicine, World Scientific Pub Co Pte Ltd, Vol. 38, No. 01 ( 2010-01), p. 99-111
Abstract:
Curcumin and saikosaponin A as antioxidants improve antioxidant status. This study investigated the anti-inflammatory and antifibrotic actions of curcumin and saikosaponin A on CCl 4 -induced liver damage. Sprague-Dawley rats were randomly divided into control, CCl 4 , CCl 4 + curcumin (0.005%; CU), CCl 4 + saikosaponin A (0.004%; SS), and CCl 4 + curcumin + saikosaponin A (0.005% + 0.004%; CU + SS) groups. Carbon tetrachloride (40% in olive oil) at a dose of 0.75 ml/kg was injected intraperitoneally once a week. Curcumin and saikosaponin A were supplemented alone or in combination with diet 1 week before CCl 4 injection for 8 weeks. After 8-week supplementation, histopathological results showed hepatic collagen deposition was significantly reduced in the CU and SS groups, and activated nuclear factor-κ B expression induced by CCl 4 in the liver was significantly inhibited by curcumin and/or saikosaponin A. Hepatic proinflammatory cytokines tumor necrosis factor-α, interleukin-1β, and interleukin-6 were significantly inhibited, and anti-inflammatory cytokine interleukin-10 was significantly increased by supplementation with curcumin and/or saikosaponin A. Additionally, curcumin and/or saikosaponin A significantly reduced the increased levels of hepatic transforming growth factor-β1 and hydroxyproline after CCl 4 treatment. Therefore, supplementation with curcumin and/or saikosaponin A suppress inflammation and fibrogenesis in rats with CCl 4 -induced liver injury. However, the combination has no additive effects on anti-inflammation and antifibrosis.
Type of Medium:
Online Resource
ISSN:
0192-415X
,
1793-6853
DOI:
10.1142/S0192415X10007695
Language:
English
Publisher:
World Scientific Pub Co Pte Ltd
Publication Date:
2010
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