In:
Molecular Systems Biology, EMBO, Vol. 9, No. 1 ( 2013-01)
Abstract:
Analysis of the cooperative nature of antibiotic inactivation reveals factors enabling coexistence of resistant and sensitive cells, showing that social interactions affect the spread of antibiotic resistance. image Inactivation of β‐lactam antibiotics by resistant bacteria is a cooperative behavior that enables sensitive bacteria to survive antibiotic treatment. At high cell densities, resistant cells protect sensitive cells against antibiotic concentrations that are 100‐fold higher than the minimum inhibitory concentration of sensitive cells. Eventually, the fraction of resistant cells in a bacterial population reaches an equilibrium fraction that depends on the initial cell density and antibiotic concentration. The addition of a commonly used β‐lactamase inhibitor can lead to the spread of resistance in the population.
Type of Medium:
Online Resource
ISSN:
1744-4292
,
1744-4292
Language:
English
Publisher:
EMBO
Publication Date:
2013
detail.hit.zdb_id:
2193510-5
SSG:
12
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