In:
Pediatric Blood & Cancer, Wiley, Vol. 55, No. 3 ( 2010-09), p. 430-433
Abstract:
Both ETV6–RUNX1 ( TEL–AML1 ) fusion and hyperdiploidy ( 〉 50 chromosomes) in transformed lymphoblasts are favorable genetic features in childhood acute lymphoblastic leukemia (ALL). Procedure Among 433 Taiwanese children with ALL diagnosed at our hospitals between 1997 and 2007, the ETV6–RUNX1 fusion was found in 15.8%, and hyperdiploidy ( 〉 50 chromosomes) in 14.1% of the patients. These frequencies were lower than those reported in the West, leading us to conduct a meta‐analysis of ETV6–RUNX1 fusion and hyperdiploidy frequencies in childhood ALL based on published reports. Results The frequency of ETV6–RUNX1 fusion in the Far East (Japan, Korea, China, Hong Kong, Chinese in Singapore, and Taiwan) was 13.4% (177/1,321, range: 9–23%, median 13%), significantly lower than the 22.8% (1,664/7,291, range: 19–26%, median 23%) in the West (West Europe and the United States) ( P 〈 0.001, odds ratio = 2.0, 95% CI: 1.7–2.4). Similarly, the frequency of hyperdiploidy in Japan and Taiwan was 14.3% (333/2,334, range: 12–20%, median 16%), significantly lower than the 25.2% in the West (5,173/20,510, range: 18–34%, median 23.5%; P 〈 0.001, odds ratio = 2.0, 95% CI: 1.8–2.3). Conclusions This meta‐analysis demonstrates lower frequencies of ETV6–RUNX1 fusion and hyperdiploidy among leukemia patients in the Far East compared with the West. The integral relationship of these genetic features with a favorable outcome in childhood ALL warrants further study of potentially important epidemiologic factors, including placental exposure to leukemogenic agents, and host pharmacogenetics. Pediatr Blood Cancer. 2010;55:430–433. © 2010 Wiley‐Liss, Inc.
Type of Medium:
Online Resource
ISSN:
1545-5009
,
1545-5017
Language:
English
Publisher:
Wiley
Publication Date:
2010
detail.hit.zdb_id:
2131448-2
detail.hit.zdb_id:
2130978-4
Permalink