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  • 1
    Online Resource
    Online Resource
    Depression is differently associated with sleep measurement in obstructive sleep apnea, restless leg syndrome and periodic limb movement disorder
    Elsevier BV ; 2019
    In:  Psychiatry Research Vol. 273 ( 2019-03), p. 37-41
    Details
    In: Psychiatry Research, Elsevier BV, Vol. 273 ( 2019-03), p. 37-41
    Type of Medium: Online Resource
    ISSN: 0165-1781
    URL: Article
    DOI: 10.1016/j.psychres.2018.12.166
    RVK:
    XA 10000
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2019
    detail.hit.zdb_id: 1500675-X
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  • 2
    Online Resource
    Online Resource
    Frontal Lobe Functions, Demoralization, Depression and Craving as Prognostic Factors and Positive Outcomes of Patients with Heroin Use Disorder Receiving 6 Months of Methadone Maintenance Treatment
    MDPI AG ; 2022
    In:  International Journal of Environmental Research and Public Health Vol. 19, No. 6 ( 2022-03-20), p. 3703-
    Details
    In: International Journal of Environmental Research and Public Health, MDPI AG, Vol. 19, No. 6 ( 2022-03-20), p. 3703-
    Abstract: Methadone maintenance therapy (MMT) is a well-established and effective treatment for heroin use disorders. Whether frontal lobe function and demoralization serve as suitable prognostic and outcome assessment factors remains unknown. A quasi-experimental study was conducted with a single-group repeated-measures design at a medical center and mental hospital in Taiwan. We enrolled 70 participants (39 completed treatments and 31 dropped out). Frontal lobe function, demoralization, depression, and craving at three time points were analyzed. There were differences between patients who completed the treatment (n = 39) and those who did not (n = 31). Thirty-nine patients completed the treatment (average age, 45.5 years; 89.7% men; average duration of heroin use, 27.21 years; MMT, 38.18 mg/day). Post-MMT (6 months), frontal lobe function, demoralization, depression, and craving significantly improved. Dropouts had higher frontal lobe function, lower demoralization, higher craving, younger age, and earlier onset age than patients who completed the pretest treatment. Clinicians should be aware of the severity of demoralization. Clinicians may select suitable patients for MMT by assessing frontal lobe function, demoralization, craving, age, and onset age. A 6-month course of MMT improved demoralization, frontal lobe function, depression, and addiction. Six months of treatment was more effective than 3 months. Suitable patient identification and continuous treatment are important in MMT.
    Type of Medium: Online Resource
    ISSN: 1660-4601
    URL: Article
    DOI: 10.3390/ijerph19063703
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2175195-X
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  • 3
    Online Resource
    Online Resource
    Demoralization in oral cancer inpatients and its association with spiritual needs, quality of life, and suicidal ideation: a cross-sectional study
    Springer Science and Business Media LLC ; 2022
    In:  Health and Quality of Life Outcomes Vol. 20, No. 1 ( 2022-12)
    Details
    In: Health and Quality of Life Outcomes, Springer Science and Business Media LLC, Vol. 20, No. 1 ( 2022-12)
    Abstract: Demoralization is a common problem in oral cancer patients owing to the chronic and severe nature of their affliction. However, the association between demoralization and the patient’s spiritual needs, quality of life, and suicidal ideation remains unclear. This study aims to provide insights into possible links between demoralization among oral cancer patients and its effects on the patient’s spiritual needs, quality of life, and suicidal ideation. Methods We examined 155 Taiwanese oral cancer inpatients in Taichung Veterans General Hospital, Taiwan, using the following three rating scales: (a) Demoralization Scale Mandarin Version (DS-MV), (b) Spiritual Interests Related to Illness Tool, and (c) The Taiwan Chinese versions of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire. Suicidal ideation was established if at least one of the two suicide-related items on the DS-MV scale were checked. We divided the participants into high- and low-demoralization groups, per the cutoff score of 30. We then explored group associations with sociodemographic features, quality of life, and spiritual needs. Logistic regression and receiver operating characteristic (ROC) curves were used to determine demoralization and its association between these variables. Results Fifty-five (35.5%) patients were categorized as having high demoralization (DS-MV scale score  〉  30), with scores for DS-MV for all patients being 27.2 ± 16.8. The rates of suicidal ideation were 29.1% (16/55) in the high-demoralization group and 2% (2/100) in the low-demoralization group, with an odds ratio (95% confidence interval) of 20.10 (4.41–91.55). Logistic regression analysis revealed significant effects of spiritual needs and global health status on the DS-MV scores ( p   〈  0.001). Multivariate analyses further confirmed that only overall quality of life scores  〈  62.5 and spiritual needs  〈  3.7 significantly predicted the occurrence of high demoralization. Conclusion High demoralization is associated with low satisfaction with spiritual needs, poor quality of life, and high risk of suicidal ideation. DS-MV may potentially be an effective tool for achieving holistic health care among oral cancer patients.
    Type of Medium: Online Resource
    ISSN: 1477-7525
    URL: Article
    DOI: 10.1186/s12955-022-01962-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2098765-1
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  • 4
    Online Resource
    Online Resource
    GJB2 p.V37I Mutation Associated With Moderate Nonsyndromic Hearing Loss in an Adult Taiwanese Population
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  Ear & Hearing Vol. Publish Ahead of Print ( 2023-06-05)
    Details
    In: Ear & Hearing, Ovid Technologies (Wolters Kluwer Health), Vol. Publish Ahead of Print ( 2023-06-05)
    Type of Medium: Online Resource
    ISSN: 1538-4667
    URL: Article
    DOI: 10.1097/AUD.0000000000001384
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    detail.hit.zdb_id: 2081799-X
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  • 5
    Online Resource
    Online Resource
    Demoralization and Its Association with Quality of Life, Sleep Quality, Spiritual Interests, and Suicide Risk in Breast Cancer Inpatients: A Cross-Sectional Study
    MDPI AG ; 2022
    In:  International Journal of Environmental Research and Public Health Vol. 19, No. 19 ( 2022-10-06), p. 12815-
    Details
    In: International Journal of Environmental Research and Public Health, MDPI AG, Vol. 19, No. 19 ( 2022-10-06), p. 12815-
    Abstract: With decreasing mortality, the quality of life, spiritual needs, and mental health of breast cancer patients have become increasingly important. Demoralization is a poor prognostic factor for cancer patients. The extent of demoralization in breast cancer patients and its association with these factors remains unclear. This cross-sectional study was conducted at a Taiwanese medical center. We enrolled 121 participants (34 with high demoralization and 87 with low demoralization, as per the Mandarin Version of Demoralization Scale). High demoralization was associated with reduced quality of life, sleep quality, and spiritual interests. Multivariate analyses revealed that the scores of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire ≥ 62.5 (OR = 0.21, p = 0.002) and Spiritual Interests Related to Illness Tool Chinese Version ≥ 3.66 (OR = 0.11, p 〈 0.001) were associated with low demoralization. Demoralized patients with depression had a poorer quality of life and sleep quality. Although not statistically significant, depressed and demoralized participants were at a higher risk of suicide. Cancer patients with both depression and demoralization had the worst prognosis. Breast cancer patients exhibited demoralization when they had unmet bio-psycho-social-spiritual needs. An early assessment of demoralization may improve holistic healthcare for breast cancer patients.
    Type of Medium: Online Resource
    ISSN: 1660-4601
    URL: Article
    DOI: 10.3390/ijerph191912815
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2175195-X
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  • 6
    Online Resource
    Online Resource
    Impacts of ADH1B rs1229984 and ALDH2 rs671 polymorphisms on risks of alcohol‐related disorder and cancer
    Wiley ; 2023
    In:  Cancer Medicine Vol. 12, No. 1 ( 2023-01), p. 747-759
    Details
    In: Cancer Medicine, Wiley, Vol. 12, No. 1 ( 2023-01), p. 747-759
    Abstract: ADH1B rs1229984 and ALDH2 rs671 are the specifically prevalent functional variants in the East Asians. These variants, which result in a dramatic change in enzyme activity, are highly associated with alcohol‐related disorders and cancer. Previous studies focusing on the additive and synergic effects of the variants are few and inconsistent. The aim of the research was to evaluate the associations of ADH1B rs1229984 and ALDH2 rs671 with the risks of alcohol‐related disorder and cancer. Methods This cohort study enrolled 42,665 participants from the Taiwan Precision Medicine Initiative database, including 19,522 and 20,534, ADH1B and ALDH2 carriers, respectively. The associations between the two variants and cancer risk were analyzed by univariable and multivariable logistic regression. Results Compared with the noncarriers, the ADH1B rs1229984 variant had a stronger effect on alcohol‐related disorders and was related to an increased risk of alcohol‐related cancers. The CC genotype of ADH1B rs1229984 was significantly associated with cancer of the larynx, pharynx, and nasal cavities [odds ratio (OR) = 1.56, p  = 0.0009], cancer of the pancreas (OR = 1.66, p  = 0.018), and cancer of the esophagus (OR = 4.10, p   〈  0.001). Participants who carried the rs1229984 TC/CC and rs671 GG genotypes were at higher risk of esophageal cancer (OR = 3.02, p   〈  0.001). The risk of esophageal cancer was increased by 381% (OR = 4.81, p   〈  0.001) in those carrying the rs1229984 TC/CC and rs671 GA/AA genotypes. Conclusion rs1229984 and rs671 are common and functionally important genetic variants in the Taiwanese population. Our findings provide strong evidence of additive and synergic risks of ADH1B and ALDH2 variants for alcohol‐related disorders and cancer. The results suggested that are reduction in alcohol consumption should be advised as a preventive measure for high‐risk patients carrying ADH1B rs1229984 C or the ALDH2 rs671 A allele.
    Type of Medium: Online Resource
    ISSN: 2045-7634 , 2045-7634
    URL: Issue
    URL: Article
    DOI: 10.1002/cam4.v12.1
    DOI: 10.1002/cam4.4920
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2659751-2
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  • 7
    Online Resource
    Online Resource
    Poorer Wisconsin card-sorting test performance in healthy adults with higher positive and negative schizotypal traits : WCST in adults with higher SPQ score
    Wiley ; 2011
    In:  Psychiatry and Clinical Neurosciences Vol. 65, No. 6 ( 2011-10), p. 596-599
    Details
    In: Psychiatry and Clinical Neurosciences, Wiley, Vol. 65, No. 6 ( 2011-10), p. 596-599
    Type of Medium: Online Resource
    ISSN: 1323-1316
    URL: Article
    DOI: 10.1111/j.1440-1819.2011.02255.x
    Language: English
    Publisher: Wiley
    Publication Date: 2011
    detail.hit.zdb_id: 2010264-1
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  • 8
    Online Resource
    Online Resource
    Sleep quality in heroin addicts under methadone maintenance treatment
    Cambridge University Press (CUP) ; 2012
    In:  Acta Neuropsychiatrica Vol. 24, No. 6 ( 2012-12), p. 356-360
    Details
    In: Acta Neuropsychiatrica, Cambridge University Press (CUP), Vol. 24, No. 6 ( 2012-12), p. 356-360
    Abstract: Hsu W-Y, Chiu N-Y, Liu J-T, Wang C-H, Chang T-G, Liao Y-C, Kuo P-I. Sleep quality in heroin addicts under methadone maintenance treatment. Background: Sleep disturbance is a common phenomenon among opiate addicts. The side effects of opiate addiction or opiate withdrawal might result in sleep disturbance. However, their problems might be related to sedative medication abuse, alcohol abuse or heroin relapse. Sleep is an important issue in this population. Objective: To evaluate the prevalence of sleep disorders in heroin addicts receiving methadone maintenance treatment (MMT) and analyse the correlation between related factors, such as age at opiate exposure, opiate exposure duration, duration in MMT, methadone current dosage, methadone attendance rate and the severity of sleep disorders. Method: We enrolled 121 heroin addicts who were receiving MMT. We collected data on the duration of insomnia, hypnotic history, Visual Analogue Scale-10 of sleep quality, Pittsburgh Sleep Quality Index (PSQI), methadone dosage, methadone history and opiate history. Results: The mean of the PSQI was 9.1 ± 5.4, and 70.2% of patients had PSQI scores 〉 5, indicating they were poor sleepers. We also found the PSQI scores were correlated significantly with the methadone dosage. Conclusions: The sleep disturbance prevalence rate of opiate addicts under MMT was high in Taiwan, as shown in the previous studies, and the severity of sleep disturbance has been underestimated.
    Type of Medium: Online Resource
    ISSN: 0924-2708 , 1601-5215
    URL: Article
    DOI: 10.1111/j.1601-5215.2011.00628.x
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2012
    detail.hit.zdb_id: 2077830-2
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  • 9
    Online Resource
    Online Resource
    ‘Pseudo-paraplegia': a chronic psychotic sequela of organophosphate exposure in schizophrenia
    Cambridge University Press (CUP) ; 2011
    In:  Acta Neuropsychiatrica Vol. 23, No. 5 ( 2011-10), p. 257-258
    Details
    In: Acta Neuropsychiatrica, Cambridge University Press (CUP), Vol. 23, No. 5 ( 2011-10), p. 257-258
    Type of Medium: Online Resource
    ISSN: 0924-2708 , 1601-5215
    URL: Article
    DOI: 10.1111/j.1601-5215.2010.00513.x
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2011
    detail.hit.zdb_id: 2077830-2
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  • 10
    Online Resource
    Online Resource
    Suicide Ideation among Outpatients with Alcohol Use Disorder
    Hindawi Limited ; 2022
    In:  Behavioural Neurology Vol. 2022 ( 2022-2-12), p. 1-7
    Details
    In: Behavioural Neurology, Hindawi Limited, Vol. 2022 ( 2022-2-12), p. 1-7
    Abstract: Introduction. Individuals with substance use disorders, particularly those with alcohol use disorder (AUD), have a high risk of suicide. Therefore, identifying risk factors for suicide in these individuals is crucial. Methods. This retrospective study reviewed the medical records of individuals with AUD who participated in an alcohol treatment program in central Taiwan during 2019–2020. We collected data using the Cut down, Annoyed, Guilty, and Eye-opener questionnaire, Alcohol Use Disorders Identification Test (AUDIT), Brief Michigan Alcoholism Screening Test (MAST), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), and a suicidal ideation question. Furthermore, we collected information on several related variables, namely, sex, age, marital status, years in school, employment status, family history of alcohol problems, age at first exposure to alcohol, duration of alcohol use, history of alcohol cessation, history of domestic violence, and history of drunk driving. In total, 136 individuals were recruited to participate in this study. Results. The suicidal ideation group had significantly younger participants, a higher proportion of women, a higher proportion of participants with a history of domestic violence, a greater severity of alcohol addiction (based on both AUDIT and MAST scores), higher depression scores, higher anxiety scores, less social support, a lower quality of life (World Health Organization Quality of Life (WHOQOL)), and poorer sleep quality (Pittsburgh Sleep Quality Index, PSQI) compared with the nonsuicidal ideation group. The suicidal ideation score was correlated with the AUDIT score after age, and BDI, BAI, WHOQOL, and PSQI scores were controlled for ( P = 0.034 ). Conclusion. Individuals with higher AUDIT scores visiting a clinic for alcohol treatment might have a higher risk of suicidal ideation. Therefore, clinicians should pay close attention to the suicidal ideation problem in this population. Furthermore, appropriate medication or management programs for suicide prevention should be considered.
    Type of Medium: Online Resource
    ISSN: 1875-8584 , 0953-4180
    URL: Article
    DOI: 10.1155/2022/4138629
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2035544-0
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