In:
The American Journal of Chinese Medicine, World Scientific Pub Co Pte Ltd, Vol. 23, No. 02 ( 1995-01), p. 173-180
Abstract:
The effect of Evodia rutaecarpa extract on cytokine secretion by human mononuclear cells in vitro was investigated. Evodia rutaecarpa extract of various concentrations in mononuclear cell culture medium showed biphasic effects on the secretion of interleukin 1 ß (IL-1 ß), interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), and granulocyte-macrophage colony stimulating factor (GM-CSF) by the mononuclear cells. Generally speaking, a low to medium level of Evodia rutaecarpa extract, in concentrations ranging from 10% to 30%, showed significant stimulating effects on the secretion of IL-1 ß, IL-6, TNF-α and GM-CSF. On the other hand, high level of Evodia rutaecarpa extract, with concentration more than 40%, lost its stimulating effects. Moreover, reaction time affected the stimulating effects of Evodia rutaecarpa extract on cytokine secretion by mononuclear cells. Mononuclear cell culture medium containing Evodia rutaecarpa extract that was allowed to react for 18 or 24 hours showed significantly better stimulating effects than that reacted for 1 or 3 hours.
Type of Medium:
Online Resource
ISSN:
0192-415X
,
1793-6853
DOI:
10.1142/S0192415X95000237
Language:
English
Publisher:
World Scientific Pub Co Pte Ltd
Publication Date:
1995
detail.hit.zdb_id:
2095946-1
detail.hit.zdb_id:
193085-0
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