In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 4 ( 2022-4-29), p. e0266966-
Abstract:
Hepatocellular carcinoma (HCC) is the most common primary liver cancer and poor prognosis. Emerging evidence suggests that epigenetic alterations play a crucial role in HCC, suggesting epigenetic inhibition as a promising therapeutic approach. Indeed, the bromodomain and extra-terminal (BET) inhibitors inhibit the proliferation and invasion of various cancers but still lack a strong mechanistic rationale. Here, we identified the differentially expressed mRNAs (DEmRNAs) and lncRNAs (DElncRNAs) in human HCC cell line HepG2 treated with the BET inhibitors, JQ1, OTX015, or ABBV-075. We analyzed the correlation between DEmRNAs and DElncRNAs in common for the three inhibitors based on their expression profiles and performed functional annotation pathway enrichment analysis. Most of these shared DEmRNAs and DElncRNAs, including some novel transcripts, were downregulated, indicating decreased proliferation/adhesion and increased apoptosis/inflammation. Our study suggests that BET proteins play a crucial role in regulating cancer progression-related genes and provide a valuable resource for novel putative biomarkers and therapeutic targets in HCC.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0266966
DOI:
10.1371/journal.pone.0266966.g001
DOI:
10.1371/journal.pone.0266966.g002
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10.1371/journal.pone.0266966.g003
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10.1371/journal.pone.0266966.g004
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10.1371/journal.pone.0266966.g005
DOI:
10.1371/journal.pone.0266966.g006
DOI:
10.1371/journal.pone.0266966.g007
DOI:
10.1371/journal.pone.0266966.g008
DOI:
10.1371/journal.pone.0266966.g009
DOI:
10.1371/journal.pone.0266966.s001
DOI:
10.1371/journal.pone.0266966.s002
DOI:
10.1371/journal.pone.0266966.s003
DOI:
10.1371/journal.pone.0266966.s004
DOI:
10.1371/journal.pone.0266966.s005
DOI:
10.1371/journal.pone.0266966.s006
DOI:
10.1371/journal.pone.0266966.s007
DOI:
10.1371/journal.pone.0266966.s008
DOI:
10.1371/journal.pone.0266966.s009
DOI:
10.1371/journal.pone.0266966.s010
DOI:
10.1371/journal.pone.0266966.s011
DOI:
10.1371/journal.pone.0266966.s012
DOI:
10.1371/journal.pone.0266966.s013
DOI:
10.1371/journal.pone.0266966.s014
DOI:
10.1371/journal.pone.0266966.s015
DOI:
10.1371/journal.pone.0266966.s016
DOI:
10.1371/journal.pone.0266966.s017
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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