In:
Surgical Neurology International, Scientific Scholar, Vol. 12 ( 2021-10-11), p. 517-
Abstract:
Intraoperative balloon electronic brachytherapy (IBEB) may provide potential benefit for local control of recurrent cerebral glioblastomas (GBMs). Methods: This is a preliminary report of an open-label, prospective, comparative cohort study conducted in two neurosurgical centers with ongoing follow-up. At recurrence, patients at one center ( n = 15) underwent reresection with IBEB while, at the second center ( n = 15), control subjects underwent re-resection with various accepted second-line adjuvant chemoradiotherapy options. A comparative analysis of overall survival (OS) and local progression-free survival (LPFS) following re-resection was performed. Exploratory subgroup analysis based on postoperative residual contrast-enhanced volume status was also done. Results: In the IBEB group, median LPFS after re-resection was significantly longer than in the control group (8.0 vs. 6.0 months; log rank χ 2 = 4.93, P = 0.026, P 〈 0.05). In addition, the median OS after second resection in the IBEB group was also significantly longer than in the control group (11.0 vs. 8.0 months; log rank χ 2 = 4.23, P = 0.04, P 〈 0.05). Conclusion: These hypothesis-generating results from a small cohort of subjects suggest putative clinical benefit in OS and LPFS associated with maximal safe re-resection of recurrent GBM with IBEB versus re-resection and standard adjuvant therapy, a hypothesis that deserves further testing in an appropriately powered clinical trial.
Type of Medium:
Online Resource
ISSN:
2152-7806
DOI:
10.25259/SNI_494_2021
Language:
English
Publisher:
Scientific Scholar
Publication Date:
2021
detail.hit.zdb_id:
2567759-7
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