In:
SLEEP, Oxford University Press (OUP), Vol. 46, No. Supplement_1 ( 2023-05-29), p. A113-A113
Abstract:
While intake of specific macronutrients has been associated with changes in sleep parameters in humans – such as sleep macrostructure – direct interventional evidence is lacking. Thus, we conducted a randomized trial to examine how consumption of an unhealthy, Western diet impacts sleep at the macrostructure to microstructure level in humans. Methods In a crossover study, 15 healthy normal-weight men consumed two isocaloric diets in random order: an unhealthy high-fat, high-sugar diet, and a healthy, low-fat, low-sugar diet. Following each week-long diet, in-lab sleep was recorded using polysomnography (PSG), during a full night of sleep, and after recovery sleep occurring after extended wakefulness. Sleep duration, macrostructure and microstructure (sleep oscillatory pattern and slow waves) were investigated using machine learning-based algorithms. Results Sleep duration did not differ across the diets, based on actigraphy and the in-lab PSG. Sleep macrostructure was similar after one week on each diet. Compared with the healthy diet, the Western diet resulted in reduced delta power and slow-wave amplitude, but increased alpha and theta power, during NREM sleep. Furthermore, the Western diet also impacted the sleep oscillatory pattern in a similar direction during the recovery sleep. Conclusion Short-term consumption of an unhealthy, Western diet modulates restorative properties of sleep, and these changes persisted even into recovery sleep. Whether such changes can mediate adverse health outcomes of an unhealthy diet warrants further investigation. Support (if any) This work was supported by the Swedish Society for Medical Research (SSMF), the Swedish Research Council, and the following foundations: Diabetesfonden (2019-489), Diabetes Wellness Sverige (25-2231), Familjen Ernfors, Göran Gustafsson (2019-1941), Selander, the Swedish Cancer Foundation (19 0269 Pj); the Swedish Brain Foundation (FO2022-0704). The study sponsor/funding agencies were not involved in the design of the study; the collection, analysis, and interpretation of data; writing the report; and did not impose any restrictions regarding the publication of the report.
Type of Medium:
Online Resource
ISSN:
0161-8105
,
1550-9109
DOI:
10.1093/sleep/zsad077.0253
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
2023
detail.hit.zdb_id:
2056761-3
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