In:
ChemistryOpen, Wiley, Vol. 11, No. 12 ( 2022-12)
Abstract:
Three new copper(II) complexes, [Cu(1,10‐Phen)(L)] ( 1 ), [Cu(2,2′‐Bpy)(L)] ( 2 ) and [Cu(3,4‐Lut)(L)] ( 3 ), where H 2 L=2‐[(2,4‐dihydroxyphenyl)methylidene]‐ N ‐(prop‐2‐en‐1‐yl)hydrazine‐1‐carbothioamide, 1,10‐Phen=1,10‐phenanthroline, 2,2′‐Bpy=2,2′‐bipyridine, 3,4‐Lut=3,4‐lutidine, have been synthesized and characterized by elemental analysis, FTIR spectroscopy and single crystal X‐ray crystallography ( 1 , 2 ). All compounds are mononuclear. The introduction of a monodentate N ‐heteroaromatic base (3,4‐dimethylpyridine) has led to a significant increase of antimicrobial activity against Gram‐negative Escherichia coli and antifungal activity against Candida albicans compared to the pro‐ligand and the precursor complex [Cu(L)H 2 O]. The introduction of bidentate N ‐heteroaromatic bases did not lead to such increase of antimicrobial and antifungal activities. Moreover, complex 3 surpasses the inhibitory activity of tetracycline toward Enterobacter cloacae and the inhibitory activity of fluconazole toward Candida parapsilosis and Cryptococcus neoformans . The study of antioxidant activity against cation radicals ABTS⋅ + showed that complexes 1 – 3 are more active than Trolox, but only introduction of the monodentate N ‐heteroaromatic base (3,4‐dimethylpyridine) led to the increase of antioxidant properties compared to the precursor complex.
Type of Medium:
Online Resource
ISSN:
2191-1363
,
2191-1363
DOI:
10.1002/open.202200208
Language:
English
Publisher:
Wiley
Publication Date:
2022
detail.hit.zdb_id:
2655605-4
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