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  • 1
    In: Global Ecology and Biogeography, Wiley, Vol. 27, No. 7 ( 2018-07), p. 760-786
    Abstract: The BioTIME database contains raw data on species identities and abundances in ecological assemblages through time. These data enable users to calculate temporal trends in biodiversity within and amongst assemblages using a broad range of metrics. BioTIME is being developed as a community‐led open‐source database of biodiversity time series. Our goal is to accelerate and facilitate quantitative analysis of temporal patterns of biodiversity in the Anthropocene. Main types of variables included The database contains 8,777,413 species abundance records, from assemblages consistently sampled for a minimum of 2 years, which need not necessarily be consecutive. In addition, the database contains metadata relating to sampling methodology and contextual information about each record. Spatial location and grain BioTIME is a global database of 547,161 unique sampling locations spanning the marine, freshwater and terrestrial realms. Grain size varies across datasets from 0.0000000158 km 2 (158 cm 2 ) to 100 km 2 (1,000,000,000,000 cm 2 ). Time period and grain BioTIME records span from 1874 to 2016. The minimal temporal grain across all datasets in BioTIME is a year. Major taxa and level of measurement BioTIME includes data from 44,440 species across the plant and animal kingdoms, ranging from plants, plankton and terrestrial invertebrates to small and large vertebrates. Software format .csv and .SQL.
    Type of Medium: Online Resource
    ISSN: 1466-822X , 1466-8238
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2018
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  • 2
    Online Resource
    Online Resource
    American Meteorological Society ; 2006
    In:  Journal of Climate Vol. 19, No. 13 ( 2006-07-01), p. 3112-3132
    In: Journal of Climate, American Meteorological Society, Vol. 19, No. 13 ( 2006-07-01), p. 3112-3132
    Abstract: An analysis of several multidecadal simulations of the present (1971–90) and future (2041–60) climate from the Canadian Regional Climate Model (CRCM) is presented. The effects on the CRCM climate of model domain size, internal variability of the general circulation model (GCM) used to provide boundary conditions, and modifications to the physical parameterizations used in the CRCM are investigated. The influence of boundary conditions is further investigated by comparing the GCM-driven simulations of the current climate with simulations performed using boundary conditions from meteorological reanalyses. The present climate of the model in these different configurations is assessed by comparing the seasonal averages and interannual variability of precipitation and surface air temperature with an observed climatology. Generally, small differences are found between the two simulations on different domains, though both domains are quite large as compared with previously reported results. Simulations driven by GCM output show a significant warm bias for wintertime surface air temperatures over northern regions. This warm bias is much reduced in the GCM-driven simulation when an updated set of physical parameterizations is used in the CRCM. The warm bias is also reduced for simulations with the standard set of physical parameterizations when the CRCM is driven with reanalysis data. However, use of the modified physics package for reanalysis-driven simulations results in surface air temperatures that are colder than the observations. Summertime precipitation in the model is much larger than observed, a bias that is present in both the GCM-driven and reanalysis-driven simulations. The bias in summertime precipitation is reduced for both types of driving data when the updated set of physical parameterizations is used. Model projections of climate change between the present and future periods are also presented and the sensitivity of these projections to many of the above-mentioned modifications is assessed. Changes in surface air temperature are predicted to be largest over northern regions in winter, with smaller changes over more southerly regions and in the summer season. Changes in seasonal average precipitation are projected to be in the range of ±10% of present-day amounts for most regions and seasons. The CRCM projections of surface air temperature changes are strongly affected by the internal variability of the driving GCM over high northern latitudes and to changes in the physical parameterizations over many regions for the summer season.
    Type of Medium: Online Resource
    ISSN: 1520-0442 , 0894-8755
    RVK:
    Language: English
    Publisher: American Meteorological Society
    Publication Date: 2006
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  • 3
    In: JAMA Oncology, American Medical Association (AMA), Vol. 8, No. 10 ( 2022-10-01), p. 1477-
    Abstract: It has become common practice to offer immunocompromised patients with hematologic cancers a third COVID-19 vaccination dose, but data substantiating this are scarce. Objective To assess whether a third mRNA-1273 vaccination is associated with increased neutralizing antibody concentrations in immunocompromised patients with hematologic cancers comparable to levels obtained in healthy individuals after the standard 2-dose mRNA-1273 vaccination schedule. Design, Setting, and Participants This prospective observational cohort study was conducted at 4 university hospitals in the Netherlands and included 584 evaluable patients spanning the spectrum of hematologic cancers and 44 randomly selected age-matched adults without malignant or immunodeficient comorbidities. Exposures One additional mRNA-1273 vaccination 5 months after completion of the standard 2-dose mRNA-1273 vaccination schedule. Main Outcomes and Measures Serum immunoglobulin G (IgG) antibodies to spike subunit 1 (S1) antigens prior to and 4 weeks after a third mRNA-1273 vaccination, and antibody neutralization capacity of wild-type, Delta, and Omicron variants in a subgroup of patients. Results In this cohort of 584 immunocompromised patients with hematologic cancers (mean [SD] age, 60 [11.2] years; 216 [37.0%] women), a third mRNA-1273 vaccination was associated with median S1-IgG concentrations comparable to concentrations obtained by healthy individuals after the 2-dose mRNA-1273 schedule. The rise in S1-IgG concentration after the third vaccination was most pronounced in patients with a recovering immune system, but potent responses were also observed in patients with persistent immunodeficiencies. Specifically, patients with myeloid cancers or multiple myeloma and recipients of autologous or allogeneic hematopoietic cell transplantation (HCT) reached median S1-IgG concentrations similar to those obtained by healthy individuals after a 2-dose schedule. Patients receiving or shortly after completing anti-CD20 therapy, CD19-directed chimeric antigen receptor T-cell therapy recipients, and patients with chronic lymphocytic leukemia receiving ibrutinib were less responsive or unresponsive to the third vaccination. In the 27 patients who received cell therapy between the second and third vaccination, S1 antibodies were preserved, but a third mRNA-1273 vaccination was not associated with significantly enhanced S1-IgG concentrations except for patients with multiple myeloma receiving autologous HCT. A third vaccination was associated with significantly improved neutralization capacity per antibody. Conclusions and Relevance Results of this cohort study support that the primary schedule for immunocompromised patients with hematologic cancers should be supplemented with a delayed third vaccination. Patients with B-cell lymphoma and allogeneic HCT recipients need to be revaccinated after treatment or transplantation. Trial Registration EudraCT Identifier: 2021-001072-41
    Type of Medium: Online Resource
    ISSN: 2374-2437
    Language: English
    Publisher: American Medical Association (AMA)
    Publication Date: 2022
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  • 4
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2003
    In:  Climate Dynamics Vol. 21, No. 5-6 ( 2003-11-1), p. 405-421
    In: Climate Dynamics, Springer Science and Business Media LLC, Vol. 21, No. 5-6 ( 2003-11-1), p. 405-421
    Type of Medium: Online Resource
    ISSN: 0930-7575 , 1432-0894
    Language: Unknown
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2003
    detail.hit.zdb_id: 382992-3
    detail.hit.zdb_id: 1471747-5
    SSG: 16,13
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  • 5
    In: Climatic Change, Springer Science and Business Media LLC, Vol. 120, No. 4 ( 2013-10), p. 965-975
    Type of Medium: Online Resource
    ISSN: 0165-0009 , 1573-1480
    RVK:
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2013
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    detail.hit.zdb_id: 1477652-2
    SSG: 14
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  • 6
    In: Advances in Geosciences, Copernicus GmbH, Vol. 21 ( 2009-08-11), p. 63-71
    Abstract: Abstract. Little quantitative knowledge is as yet available about the role of hydrological model complexity for climate change impact assessment. This study investigates and compares the varieties of different model response of three hydrological models (PROMET, Hydrotel, HSAMI), each representing a different model complexity in terms of process description, parameter space and spatial and temporal scale. The study is performed in the Ammer watershed, a 709 km2 catchment in the Bavarian alpine forelands, Germany. All models are driven and validated by a 30-year time-series (1971–2000) of observation data. It is expressed by objective functions, that all models, HSAMI and Hydrotel due to calibration, perform almost equally well for runoff simulation over the validation period. Some systematic deviances in the hydrographs and the spatial patterns of hydrologic variables are however quite distinct and thus further discussed. Virtual future climate (2071–2100) is generated by the Canadian Regional Climate Model (vers 3.7.1), driven by the Coupled Global Climate Model (vers. 2) based on an A2 emission scenario (IPCC 2007). The hydrological model performance is evaluated by flow indicators, such as flood frequency, annual 7-day and 30-day low flow and maximum seasonal flows. The modified climatic boundary conditions cause dramatic deviances in hydrologic model response. HSAMI shows tremendous overestimation of evapotranspiration, while Hydrotel and PROMET behave in comparable range. Still, their significant differences, like spatially explicit patterns of summerly water shortage or spring flood intensity, highlight the necessity to extend and quantify the uncertainty discussion in climate change impact analysis towards the remarkable effect of hydrological model complexity. It is obvious that for specific application purposes, water resources managers need to be made aware of this effect and have to take its implications into account for decision making. The paper concludes with an outlook and a proposal for future research necessities.
    Type of Medium: Online Resource
    ISSN: 1680-7359
    Language: English
    Publisher: Copernicus GmbH
    Publication Date: 2009
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  • 7
    In: Hydrology and Earth System Sciences, Copernicus GmbH, Vol. 17, No. 3 ( 2013-03-19), p. 1189-1204
    Abstract: Abstract. In climate change impact research, the assessment of future river runoff as well as the catchment-scale water balance is impeded by different sources of modeling uncertainty. Some research has already been done in order to quantify the uncertainty of climate projections originating from the climate models and the downscaling techniques, as well as from the internal variability evaluated from climate model member ensembles. Yet, the use of hydrological models adds another layer of uncertainty. Within the QBic3 project (Québec–Bavarian International Collaboration on Climate Change), the relative contributions to the overall uncertainty from the whole model chain (from global climate models to water management models) are investigated using an ensemble of multiple climate and hydrological models. Although there are many options to downscale global climate projections to the regional scale, recent impact studies tend to use regional climate models (RCMs). One reason for that is that the physical coherence between atmospheric and land-surface variables is preserved. The coherence between temperature and precipitation is of particular interest in hydrology. However, the regional climate model outputs often are biased compared to the observed climatology of a given region. Therefore, biases in those outputs are often corrected to facilitate the reproduction of historic runoff conditions when used in hydrological models, even if those corrections alter the relationship between temperature and precipitation. So, as bias correction may affect the consistency between RCM output variables, the use of correction techniques and even the use of (biased) climate model data itself is sometimes disputed among scientists. For these reasons, the effect of bias correction on simulated runoff regimes and the relative change in selected runoff indicators is explored. If it affects the conclusion of climate change analysis in hydrology, we should consider it as a source of uncertainty. If not, the application of bias correction methods is either unnecessary to obtain the change signal in hydro-climatic projections, or safe to use for the production of present and future river runoff scenarios as it does not alter the change signal. The results of the present paper highlight the analysis of daily runoff simulated with four different hydrological models in two natural-flow catchments, driven by different regional climate models for a reference and a future period. As expected, bias correction of climate model outputs is important for the reproduction of the runoff regime of the past, regardless of the hydrological model used. Then again, its impact on the relative change of flow indicators between reference and future periods is weak for most indicators, with the exception of the timing of the spring flood peak. Still, our results indicate that the impact of bias correction on runoff indicators increases with bias in the climate simulations.
    Type of Medium: Online Resource
    ISSN: 1607-7938
    Language: English
    Publisher: Copernicus GmbH
    Publication Date: 2013
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  • 8
    In: eClinicalMedicine, Elsevier BV, Vol. 61 ( 2023-07), p. 102040-
    Type of Medium: Online Resource
    ISSN: 2589-5370
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 2946413-4
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  • 9
    Online Resource
    Online Resource
    Wiley ; 2013
    In:  International Journal of Climatology Vol. 33, No. 3 ( 2013-03-15), p. 758-769
    In: International Journal of Climatology, Wiley, Vol. 33, No. 3 ( 2013-03-15), p. 758-769
    Abstract: Paleoclimate reconstructions are generally validated on recent periods. To obtain a set of instrumental records at the regional scale, a time series of monthly mean temperatures in Northeastern Canada were interpolated for the 1961–2000 period. Records were provided by 202 meteorological stations. Temperatures derived from a Canadian regional climate model (Climate Model CRCM 4.2.3 from the AMNO domain produced at ∼50 km resolution) were added as secondary information to take into account local heterogeneity and temporal dependencies. Geostatistical interpolation of the measured temperature was calculated using CRCM modelled data as a covariable and then compared to an ordinary kriging performed on a time series of mean temperature anomalies. Spherical distances between locations were calculated taking into account the curvature of the Earth with monthly semivariances being modelled using Cauchy variograms. Mean absolute error values (1.5 ± 1.2 °C) were calculated for the whole period using cross‐validation procedures. Errors were found to have the same order of magnitude in the central part of the study area where few recorded temperatures were available. Monthly mean temperature grids are publicly available through the Institut National de la Recherche Scientifique ( http://url.in.rs/3P ). Copyright © 2012 Royal Meteorological Society
    Type of Medium: Online Resource
    ISSN: 0899-8418 , 1097-0088
    URL: Issue
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    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 1491204-1
    SSG: 14
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  • 10
    Online Resource
    Online Resource
    American Geophysical Union (AGU) ; 2007
    In:  Geophysical Research Letters Vol. 34, No. 20 ( 2007-10-31)
    In: Geophysical Research Letters, American Geophysical Union (AGU), Vol. 34, No. 20 ( 2007-10-31)
    Type of Medium: Online Resource
    ISSN: 0094-8276
    Language: English
    Publisher: American Geophysical Union (AGU)
    Publication Date: 2007
    detail.hit.zdb_id: 2021599-X
    detail.hit.zdb_id: 7403-2
    SSG: 16,13
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