In:
Cholesterol, Hindawi Limited, Vol. 2010 ( 2010-02-24), p. 1-3
Abstract:
Objective . To assess the effectiveness of niacin/fish oil combination therapy in reducing Lipoprotein (a) [Lp(a)] levels after twelve weeks of therapy. Background . Lipoprotein (a) accumulates in atherosclerotic lesions and promotes smooth muscle cell growth and is both atherogenic and thrombogenic. A clinical trials of combination therapy for the reduction of Lp(a) has not been previously reported. Methods . The study was an observational study following subjects with an elevated Lp(a) (70 nmol/L) to assess impact of 12 weeks of combination Omega 3FA, niacin, and the Mediterranean diet on Lp(a). Results . Twenty three patients were enrolled with 7 patients lost to follow up and 2 patients stopped due to adverse events. The average Lp(a) reduction in the remaining 14 subjects after 12 weeks of combination therapy was 17% with a significant association of the reduction of Lp(a) with increasing baseline levels of Lp(a) [, ]. Conclusions . There was a significant reduction in Lp(a) levels with combination therapy. A more pronounced effect was noted in patients with higher baseline levels of Lp(a).
Type of Medium:
Online Resource
ISSN:
2090-1283
,
2090-1291
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2010
detail.hit.zdb_id:
2595398-9
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