In:
PLOS Genetics, Public Library of Science (PLoS), Vol. 17, No. 4 ( 2021-4-22), p. e1009484-
Abstract:
Primary cilia are microtubule-based organelles present on most cells that regulate many physiological processes, ranging from maintaining energy homeostasis to renal function. However, the role of these structures in the regulation of behavior remains unknown. To study the role of cilia in behavior, we employ mouse models of the human ciliopathy, Bardet-Biedl Syndrome (BBS). Here, we demonstrate that BBS mice have significant impairments in context fear conditioning, a form of associative learning. Moreover, we show that postnatal deletion of BBS gene function, as well as congenital deletion, specifically in the forebrain, impairs context fear conditioning. Analyses indicated that these behavioral impairments are not the result of impaired hippocampal long-term potentiation. However, our results indicate that these behavioral impairments are the result of impaired hippocampal neurogenesis. Two-week treatment with lithium chloride partially restores the proliferation of hippocampal neurons which leads to a rescue of context fear conditioning. Overall, our results identify a novel role of cilia genes in hippocampal neurogenesis and long-term context fear conditioning.
Type of Medium:
Online Resource
ISSN:
1553-7404
DOI:
10.1371/journal.pgen.1009484
DOI:
10.1371/journal.pgen.1009484.g001
DOI:
10.1371/journal.pgen.1009484.g002
DOI:
10.1371/journal.pgen.1009484.g003
DOI:
10.1371/journal.pgen.1009484.g004
DOI:
10.1371/journal.pgen.1009484.g005
DOI:
10.1371/journal.pgen.1009484.g006
DOI:
10.1371/journal.pgen.1009484.s001
DOI:
10.1371/journal.pgen.1009484.s002
DOI:
10.1371/journal.pgen.1009484.s003
DOI:
10.1371/journal.pgen.1009484.s004
DOI:
10.1371/journal.pgen.1009484.s005
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2186725-2
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