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  • 1
    Online Resource
    Online Resource
    Trans Tech Publications, Ltd. ; 2015
    In:  Advanced Materials Research Vol. 1128 ( 2015-10), p. 127-133
    In: Advanced Materials Research, Trans Tech Publications, Ltd., Vol. 1128 ( 2015-10), p. 127-133
    Abstract: Using new high entropy alloy with chemical formula AlCrNiCuMn produced by high technology (induction melt method), in manufacture of new composite materials will enable the creation of new structures resistant to stress used dynamic collective protection. Specify that High Entropy Alloys are characterized as alloys consisting of approximate equal concentrations of at least five metallic elements and are claimed to favor close-packed, disordered structures due to high configurational entropy. In this study, we investigate the microstructure and corrosion properties of AlCrNiCuMn high-entropy alloys. The type of high entropy alloys manufactured was a five-component alloy of AlCrNiCuMn. The microstructure and corrosion resistance property of high-entropy alloys AlCrNiCuMn were determined by scanning electron microscopy and electrochemical workstation. Microstructural characterization was performed by electron microscopy on LMHII VegaTescan equipment using a secondary electron detector (SE) at a voltage of 30 kV electron gun.
    Type of Medium: Online Resource
    ISSN: 1662-8985
    URL: Issue
    Language: Unknown
    Publisher: Trans Tech Publications, Ltd.
    Publication Date: 2015
    detail.hit.zdb_id: 2265002-7
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  • 2
    In: Food Chemistry, Elsevier BV, Vol. 153 ( 2014-06), p. 109-113
    Type of Medium: Online Resource
    ISSN: 0308-8146
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2014
    detail.hit.zdb_id: 1483647-6
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  • 3
    Online Resource
    Online Resource
    Canadian Center of Science and Education ; 2014
    In:  Journal of Food Research Vol. 3, No. 4 ( 2014-04-09), p. 33-
    In: Journal of Food Research, Canadian Center of Science and Education, Vol. 3, No. 4 ( 2014-04-09), p. 33-
    Abstract: 〈 p 〉 Pasta represents an identifying ingredient of traditional healthy dishes, in particular in Mediterranean areas. Traditional pasta is made with durum wheat semolina only. However, pasta manufactured with different cereals has become available on the market and its consumption is rapidly increasing. 〈 /p 〉 〈 p 〉 Five experimental dry pastas, manufactured with the same process by adding 60% wholegrain flours of different cereals (wheat, oat, rye, barley and rice) to the same durum wheat semolina, were supplied by Pavan s.p.a. (Galliera Veneta, PD, Italy). 〈 /p 〉 〈 p 〉 For each product, aqueous-organic extracts and their residues were studied. Their antioxidant properties were evaluated by FRAP (Ferric Reducing Antioxidant Power) assay and Total Polyphenols Content (TPC) was determined by the Folin Ciocalteau method. 〈 /p 〉 〈 p 〉 For cooked experimental wholegrain pastas made with different cereals, FRAP values ranged from 3.26 ± 0.08 µmol/g d.w. to 19.52 ± 1.28 µmol/g d.w. in aqueous-organic extracts and from 17.91 ± 2.83 µmol/g d.w. to 87.83 ± 5.06 µmol/g d.w. in residues. In both raw and cooked products the lowest FRAP values were found for semolina/60% whole rice pasta. 〈 /p 〉 〈 p 〉 The barley pasta has interesting antioxidant properties and this result was matched by the TPC one. 〈 /p 〉 〈 p 〉 〈 strong 〉 Practical Application 〈 /strong 〉 〈 strong 〉 〈 /strong 〉 〈 /p 〉 〈 p 〉 The interest in more nutritious and potentially functional foods has prompted the cereal industry towards new formulations of wholegrain products. The functional properties of minor cereals have been poorly investigated. Our results show that wholegrain pastas made with different cereals are rich in antioxidants, in particular whole barley based pasta, providing a scientific basis for the development of grain 〈 span style="text-decoration: line-through;" 〉 s 〈 /span 〉 based functional foods. 〈 /p 〉 〈 p 〉 Then the study of free and bond bioactive compounds could be crucial to describe the potential of grains, with the aim of better understanding potential health benefits of wholegrain based food consumption. 〈 /p 〉
    Type of Medium: Online Resource
    ISSN: 1927-0895 , 1927-0887
    Language: Unknown
    Publisher: Canadian Center of Science and Education
    Publication Date: 2014
    detail.hit.zdb_id: 2651456-4
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  • 4
    In: Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 40, No. 16_suppl ( 2022-06-01), p. 2025-2025
    Abstract: 2025 Background: Brain metastases (BM) from primary colorectal cancer (prCRC) are rare (1-3%); few is known about CRC BM predictive factors, prognosticators and molecular pathways. High rate of HER2 amplification ( HER2+) in CRC with BM was previously described, being HER2+ overall rare in CRC ( 〈 5%); however, HER2+ impact on prognosis of CRC with BM is uncertain. Enrichment in high microsatellite instability (MSI-H) and BRAFV600E mutations (mut) was also documented in BM tissue compared to matched prCRC. We designed this study to describe molecular landscape and clinical characteristics of CRC with BM, with special focus on HER2. Methods: HEROES was a retrospective-prospective, observational study in which patients (pts) with resected BM from CRC and treated at our institution from 1 January 2010 until 31 December 2021 were enrolled to perform extensive molecular analysis of matched prCRC and BM tissue. Molecular characterization and TMB were obtained with Next Generation Sequencing (NGS, FoundationOne CDx). RAS/BRAF and MSI were respectively assessed with MassArray (Myriapod Colon Status kit) and immunohistochemistry (IHC) to validate NGS results. HER2 status was assessed with IHC/in situ hybridization (ISH). Tumor-infiltrating lymphocytes (TILs) were counted on hematoxylin-eosin-stained tissue. TMB was defined high if ≥ 5.02 mut/mB; TILs if ≥ 1.6 (cutoff set with ROC curve using R software v 4.1.2). Primary objective was to describe molecular landscape of paired BM and prCRC, with special focus on HER2. Secondary objectives were to search for new prognosticators of PFS after BM resection (BM-PFS), intracranial-only PFS (BM-iPFS) after BM resection, and OS in pts with resected BM from CRC. Results: Out of 100 pts with BM from CRC, 22 underwent BM resection and were included in the analysis. 18 out of 22 pts were aged ≥ 70 (82%); 19 (86%) had left colon or rectal origin. 17 (70%) had concomitant lung metastases. HER2+ was found on 4 (18%) BM, 3 (14%) of which had also HER2+ in matched prCRC; 3 (14%) BM carried BRAFV600Emut; 2 (9%) BM had MSI-H. Acquired HER2+ and BRAFV600Emut on BM were reported in two different pts. KRASmut were consistent between BM and prCRC. Factors positively influencing BM-iPFS were low TMB (HR 0.36; 95%CI 0.12-1.10; p = 0.0275) and absence of HER2 ( HER2neg) on BM (HR 0.20; 95%CI 0.03-1,52; p = 0.0013). HER2neg BM were also related to longer BM-PFS (HR 0.35; 95%CI 0.07-1.76; p=0.0402), as well as KRASmut BM (HR 0.35; 95%CI 0.11-1.06; p=0.0096). Longer OS was found in pts with ECOG PS 0-1 (p 〈 0.0001), with ≤ 1 metastatic site (HR 0.30; 95%CI 0.09-0.94; p = 0.0076) or with high TILs in prCRC (HR 0.32; 95%CI 0.10-1.03; p = 0.0368). Conclusions: Even with the limitation of small sample size, this study supports HER2+ enrichment in both prCRC and BM from CRC. HER2neg, low TMB or KRASmut BM conferred better prognosis. ECOG PS 0-1, ≤ 1 metastatic site and TILs-enriched prCRC were related to better OS.
    Type of Medium: Online Resource
    ISSN: 0732-183X , 1527-7755
    RVK:
    RVK:
    Language: English
    Publisher: American Society of Clinical Oncology (ASCO)
    Publication Date: 2022
    detail.hit.zdb_id: 2005181-5
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  • 5
    In: Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 34, No. 4_suppl ( 2016-02-01), p. 733-733
    Abstract: 733 Background: Few data are available on outcome of clinical practice unselected patients (pts) with mCRC. Methods: We retrospectively collected data of pts with mCRC followed at our Institution from January 2010 to December 2013 evaluating the clinical characteristics, treatments and survival outcomes. Results: A total of 584 pts were evaluated, 461 were followed at our Center while 123 were seen for a second opinion. Median age was 66 ys (25-94), 59% were male, 63% had an ECOG PS = 0 while 11% ≥2. 33% had right colon primary, 68% synchronous metastatic (mts) disease and 70% a single mts site. 81% underwent surgery on primary and 41% on metastases. 51% were RAS mutated (mut) and 5% BRAF mut. 57 pts didn't receive any systemic treatment, 33 due to frail clinical conditions and 24 due to radical surgical approach (R0). Among 404 treated pts, 239 received all 3 available cytotoxic agents (oxaliplatin, irinotecan, 5FU), 324 bevacizumab and 98 anti-EGFR; 153 (38%) were enrolled in clinical trials. Median overall survival (OS) was 27.6 months (mo) for the entire mCRC population, 3.7 mo for untreated frail pts, 28.7 mo for treated pts while it is still not reached for untreated R0 pts. OS was significantly longer for pts receiving first line combination therapy (29 vs 17 mo, p 〈 0.01) while a poor prognosis was confirmed for BRAF mut pts (p 〈 0.001). In a multivariate analysis age 〈 70, PS 0 and R0 surgery on mts disease showed a positive prognostic impact on OS while a right site of primary was a negative predictor of outcome. At logistic regression older age, low PS and peritoneal disease negatively affected the possibility to receive all 3 active drugs. Conclusions: Despite being an unselected population our outcomes are comparable with results of clinical trials in the corresponding period. We feel that such positive evidence derives from a personalization of treatment and a multidisciplinary approach to mts disease.
    Type of Medium: Online Resource
    ISSN: 0732-183X , 1527-7755
    RVK:
    RVK:
    Language: English
    Publisher: American Society of Clinical Oncology (ASCO)
    Publication Date: 2016
    detail.hit.zdb_id: 2005181-5
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  • 6
    Online Resource
    Online Resource
    Elsevier BV ; 2013
    In:  Food Chemistry Vol. 140, No. 4 ( 2013-10), p. 666-671
    In: Food Chemistry, Elsevier BV, Vol. 140, No. 4 ( 2013-10), p. 666-671
    Type of Medium: Online Resource
    ISSN: 0308-8146
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2013
    detail.hit.zdb_id: 1483647-6
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  • 7
    In: LWT - Food Science and Technology, Elsevier BV, Vol. 62, No. 1 ( 2015-06), p. 753-763
    Type of Medium: Online Resource
    ISSN: 0023-6438
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2015
    detail.hit.zdb_id: 1469139-5
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  • 8
    In: Cereal Chemistry, Wiley, Vol. 90, No. 2 ( 2013-03), p. 169-171
    Abstract: Lignans are of increasing interest because of their potential anticarcinogenic, antioxidant, estrogenic, and antiestrogenic activities. In this work, mixed‐cereal pastas manufactured by adding 60% whole‐grain flours of different cereals (wheat, oat, rye, barley, and rice) to durum wheat semolina, a multigrain pasta with different grains (cereals, legumes, and flaxseed), and a traditional industrial durum wheat semolina were analyzed for their lignans content both in the raw and in the cooked state, ready for consumption. For raw mixed‐cereal pastas, total lignans were within the range 94.91–485.62 μg/100 g d.w. After cooking, total lignans losses of about 35.5, 18.31, and 5.46% were observed respectively in oat‐, rye‐, and rice‐added pastas, whereas increases of 5.74 and 13.62% were observed in barley‐added and whole durum wheat pastas. Interesting results were obtained for the multigrain pasta: the raw product exhibited a total lignans content of 9,686.17 ± 287.03 μg/100 g d.w., and the major contribution was given by secoisolariciresinol. This highest total lignans value resulted from its rich and varied composition in seeds of different origin, legumes, and flaxseed in particular. Our findings showed that mixed‐cereal and multigrain pastas can be considered a good source of lignans. The effect of cooking was not the same for each product, and it depended on the different lignans profile of each grain, on the different chemical structure of each lignan, and on the nature of the food matrix.
    Type of Medium: Online Resource
    ISSN: 0009-0352 , 1943-3638
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 2016053-7
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