GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    Modified robot-assisted nephroureterectomy with ureteral catheterization for radical resection of the distal ureter: Procedures and short-term outcomes
    Elsevier BV ; 2024
    In:  Heliyon Vol. 10, No. 8 ( 2024-04), p. e29198-
    Details
    In: Heliyon, Elsevier BV, Vol. 10, No. 8 ( 2024-04), p. e29198-
    Type of Medium: Online Resource
    ISSN: 2405-8440
    URL: Article
    DOI: 10.1016/j.heliyon.2024.e29198
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2024
    detail.hit.zdb_id: 2835763-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    The application value of multi-parameter cystoscope in improving the accuracy of preoperative bladder cancer grading
    Springer Science and Business Media LLC ; 2022
    In:  BMC Urology Vol. 22, No. 1 ( 2022-12)
    Details
    In: BMC Urology, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2022-12)
    Abstract: To develop and validate a preoperative cystoscopic-based predictive model for predicting postoperative high-grade bladder cancer (BCa), which could be used to guide the surgical selection and postoperative treatment strategies. Materials and methods We retrospectively recruited 366 patients with cystoscopy biopsy for pathology and morphology evaluation between October 2010 and January 2021. A binary logistic regression model was used to assess the risk factors for postoperative high-grade BCa. Diagnostic performance was analyzed by plotting receiver operating characteristic curve and calculating area under the curve (AUC), sensitivity, specificity. From January 2021 to July 2021, we collected 105 BCa prospectively to validate the model's accuracy. Results A total of 366 individuals who underwent transurethral resection of bladder tumor (TURBT) or radical cystectomy following cystoscopy biopsy were included for analysis. 261 (71.3%) had a biopsy pathology grade that was consistent with postoperative pathology grade. We discovered five cystoscopic parameters, including tumor diameter, site, non-pedicled, high-grade biopsy pathology, morphology, were associated with high-grade BCa. The established multi-parameter logistic regression model (“JSPH” model) revealed AUC was 0.917 ( P   〈  0.001). Sensitivity and specificity were 86.2% and 84.0%, respectively. And the consistency of pre- and post-operative high-grade pathology was improved from biopsy-based 70.5% to JSPH model-based 85.2%. In a 105-patients prospective validation cohort, the consistency of pre- and post-operative high-grade pathology was increased from 63.1 to 84.2% after incorporation into JSPH model for prediction. Conclusion The cystoscopic parameters based “JSPH model” is accurate at predicting postoperative pathological high-grade tumors prior to operations.
    Type of Medium: Online Resource
    ISSN: 1471-2490
    URL: Article
    DOI: 10.1186/s12894-022-01054-z
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2059857-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    External validation of Pentafecta in patients undergoing laparoscopic radical cystectomy: results from a high-volume center
    Springer Science and Business Media LLC ; 2022
    In:  BMC Urology Vol. 22, No. 1 ( 2022-12)
    Details
    In: BMC Urology, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2022-12)
    Abstract: To investigate whether Pentafecta is suitable for bladder cancer patients receiving laparoscopic radical cystectomy (LRC). Methods From November 2013 to December 2020, muscle invasive Bladder Cancer (MIBC) and non-muscle invasive Bladder Cancer (NMIBC) patients who received LRC and urinary diversion were retrospectively analyzed. Pentafecta was defined as meeting five criteria: negative soft margin, ≥ 16 lymph nodes (LNs) removed, major complications free, urinary diversion related sequelae free and clinical recurrence free within 1 year. Analyze the achievement of five criteria and compare the overall survival (OS) of Pentafecta group with non-attainment group. Multivariable Cox’s regression was performed to evaluate the impact of Pentafecta on OS. Multivariable logistic regression was performed to explore the effect of surgical experience on Pentafecta attainment. Results A total of 340 patients were included, negative soft margin, ≥ 16 lymph nodes (LNs) removed, major complications free, urinary diversion related sequelae free and clinical recurrence free within 1 year were observed in 95.3%, 30.3%, 83.8%, 75.0% and 85.6% of patients, respectively. Pentafecta group had a significantly longer OS than the non-attainment group ( P  = 0.027). The group with 10–15 LNs removed and meeting the other four criteria had a similar OS to group with ≥ 16 LNs removed (Pentafecta group) (5-year OS: 67.3% vs 72.7%, P  = 0.861). Pentafecta (HR = 0.33, P  = 0.011), positive lymph nodes (HR = 2.08, P  = 0.028) and MIBC (HR = 3.70, P   〈  0.001) were all significant predictors of OS in multivariable Cox’s regression. Surgical experience (OR = 1.05, P   〈  0.001), conduit (OR = 2.09, P  = 0.047) and neobladder (OR = 2.47, P  = 0.048) were all independent predictors of Pentafecta attainment in multivariable logistic regression. Conclusions Pentafecta is suitable for bladder cancer patients receiving LRC and has the potential to be a valuable tool for evaluating the quality of LRC. Based on Pentafecta analysis, removing 10 LNs instead of 16 LNs as the one of the five criteria may be more appropriate for bladder cancer patients.
    Type of Medium: Online Resource
    ISSN: 1471-2490
    URL: Article
    DOI: 10.1186/s12894-022-00987-9
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2059857-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Research progress on hCNT3 structure/ function and nucleoside anticancer drugs
    Bentham Science Publishers Ltd. ; 2023
    In:  Current Protein & Peptide Science Vol. 24 ( 2023-09-05)
    Details
    In: Current Protein & Peptide Science, Bentham Science Publishers Ltd., Vol. 24 ( 2023-09-05)
    Abstract: Membrane protein human concentrative nucleoside transporter 3 (hCNT3) can not only transport extracellular nucleosides into the cell but also transport various nucleoside-derived anticancer drugs to the focus of infection for therapeutic effects. Typical nucleoside anticancer drugs, including fludarabine, cladabine, decitabine, and clofarabine, are recognized by hCNT3 and then delivered to the lesion site for their therapeutic effects. hCNT3 is highly conserved during the evolution from lower to higher vertebrates, which contains scaffold and transport domains in structure and delivers substrates by coupling with Na+ and H+ ions in function. In the process of substrate delivery, the transport domain rises from the lower side of transmembrane 9 (TM9) in the inward conformation to the upper side of the outward conformation, accompanied by the collaborative motion of TM7b/ TM4b and hairpin 1b (HP1b)/ HP2b. With the report of a series of three-dimensional structures of homologous CNTs, the structural characteristics and biological functions of hCNT3 have attracted increasing attention from pharmacists and biologists. Our research group has also recently designed an anticancer lead compound with high hCNT3 transport potential based on the structure of 5-fluorouracil. In this work, the sequence evolution, conservation, molecular structure, cationic chelation, substrate recognition, elevator motion pattern and nucleoside derivative drugs of hCNT3 were reviewed, and the differences in hCNT3 transport mode and nucleoside anticancer drug modification were summarized, aiming to provide theoretical guidance for the subsequent molecular design of novel anticancer drugs targeting hCNT3.
    Type of Medium: Online Resource
    ISSN: 1389-2037
    URL: Article
    DOI: 10.2174/1389203724666230905110952
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2023
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Mechanics of the penetration and filtration of cement-based grout in porous media: New insights from CFD–DEM simulations
    Elsevier BV ; 2023
    In:  Tunnelling and Underground Space Technology Vol. 133 ( 2023-03), p. 104928-
    Details
    In: Tunnelling and Underground Space Technology, Elsevier BV, Vol. 133 ( 2023-03), p. 104928-
    Type of Medium: Online Resource
    ISSN: 0886-7798
    URL: Article
    DOI: 10.1016/j.tust.2022.104928
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 2022637-8
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Renal Functional and Perioperative Outcomes of Retroperitoneal Robot-Assisted Versus Laparoscopic Partial Nephrectomy with Segmental Renal Artery Clamping
    Mary Ann Liebert Inc ; 2022
    In:  Journal of Laparoendoscopic & Advanced Surgical Techniques Vol. 32, No. 5 ( 2022-05-01), p. 545-549
    Details
    In: Journal of Laparoendoscopic & Advanced Surgical Techniques, Mary Ann Liebert Inc, Vol. 32, No. 5 ( 2022-05-01), p. 545-549
    Type of Medium: Online Resource
    ISSN: 1092-6429 , 1557-9034
    URL: Article
    DOI: 10.1089/lap.2021.0437
    Language: English
    Publisher: Mary Ann Liebert Inc
    Publication Date: 2022
    detail.hit.zdb_id: 2035583-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    A Nomogram of MRI Features to Assess Muscle Invasion in VI‐RADS 2 Tumors With Stalk
    Wiley ; 2024
    In:  Journal of Magnetic Resonance Imaging Vol. 59, No. 4 ( 2024-04), p. 1179-1190
    Details
    In: Journal of Magnetic Resonance Imaging, Wiley, Vol. 59, No. 4 ( 2024-04), p. 1179-1190
    Abstract: Vesical Imaging–Reporting and Data System (VI‐RADS) is widely used to assess the muscle‐invasive status of bladder cancer. However, the current classification efficacy of VI‐RASD 2 tumors of stalk is unsatisfactory. Purpose To develop a nomogram to assess muscle‐invasive bladder cancer (MIBC) in VI‐RADS 2 tumors with stalk. Study Type Retrospective. Population A total of 186 patients (age: 67.8 ± 12.7 years) with 15.1% females, divided randomly into a training cohort ( N = 130) and validation cohort ( N = 56). Field Strength/Sequence 3‐T, T2‐weighted imaging (turbo spin‐echo), diffusion‐weighted imaging (breathing‐free spin‐echo), and dynamic contrast‐enhanced imaging (gradient‐echo). Assessment Twenty‐one MRI features of tumors and stalks were developed from training cohort. The mean apparent diffusion coefficient (ADC) values of the tumor, stalk, and psoas muscles were calculated from the three circular regions of interest. The normalized T . The normalized ST . Three readers assessed the morphology of tumors and stalks. Statistical Tests The final features of nomogram were selected by univariable logistic and the least absolute shrinkage and selection operator (LASSO) regression. The performance of the nomogram was assessed by the receiver operating characteristic (ROC) curve, calibration, and decision curve analysis. Results In VI‐RADS 2 tumors with stalk, tumor size over 3 cm, increased stalk width, stalk morphology, decreased normalized T value, and increased normalized ST value were selected as the risk factors for MIBC. The AUC, accuracy, sensitivity, and specificity of the nomogram to assess MIBC were 0.969 (95% CI: 0.941–0.997), 92.3%, 94.1%, and 92.0% in training cohort and 0.940 (95% CI: 0.859–1.000), 89.3%, 75.0%, and 91.7% in validation cohort. Data Conclusion This study constructed a nomogram for preoperative assessment of MIBC and modifying the current VI‐RADS. Level of Evidence 3 Technical Efficacy Stage 2
    Type of Medium: Online Resource
    ISSN: 1053-1807 , 1522-2586
    URL: Issue
    URL: Article
    DOI: 10.1002/jmri.v59.4
    DOI: 10.1002/jmri.28924
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 1497154-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    MP32-17 PREDICTING THE MIBC IN STALKED TUMOR OF VI-RADS 2 USING NOMOGRAM OF MRI CHARACTERISTICS
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  Journal of Urology Vol. 209, No. Supplement 4 ( 2023-04)
    Details
    In: Journal of Urology, Ovid Technologies (Wolters Kluwer Health), Vol. 209, No. Supplement 4 ( 2023-04)
    Type of Medium: Online Resource
    ISSN: 0022-5347 , 1527-3792
    URL: Article
    DOI: 10.1097/JU.0000000000003265.17
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    Shenqi Fuzheng Injection impairs bile duct ligation-induced cholestatic liver injury in vivo
    Portland Press Ltd. ; 2019
    In:  Bioscience Reports Vol. 39, No. 1 ( 2019-01-31)
    Details
    In: Bioscience Reports, Portland Press Ltd., Vol. 39, No. 1 ( 2019-01-31)
    Abstract: Background and aim: The aim of the present study sought to determine the protective function of Shenqi Fuzheng Injection (SFI) in cholestatic liver injury. Methods: Cholestatic liver injury was induced in a 7-day bile duct-ligated (BDL) rat model. Rats were divided into three groups that were comprised of: (1) Sham; (2) BDL model; and (3) SFI treatment. The sham and BDL groups were treated with an appropriate volume of 0.9% sodium chloride as the vehicle, and the SFI group was administered SFI at a dose of 20 ml/kg/day, via tail vein injection. Results: SFI significantly (all at P & lt;0.01) decreased the levels of serum aspartate aminotransferase and alanine aminotransferase as compared with the BDL group, which was associated with reduced severity of inflammatory cell infiltration and hepatic damage. Moreover, SFI significantly decreased the levels of hepatic interleukin-6 (P & lt;0.01), tumor necrosis factor-α (P=0.041), and malondialdehyde (P=0.026), and significantly increased the levels of total superoxide dismutase (P & lt;0.01), and the GSH/GSSG ratio (P=0.041) in the liver. Western blot analysis showed that SFI increased PPAR-γ expression; however, SFI treatment decreased cyclooxygenase-2 (COX-2) expression and the phosphorylation of NF-κBp65. Conclusions: These data demonstrated that SFI attenuated both inflammation and oxidative stress, and disrupted cholestatic liver injury. The involved mechanism was dependent, at least in part, on regulating PPAR-γ, COX-2, and NF-κBp65 expression.
    Type of Medium: Online Resource
    ISSN: 0144-8463 , 1573-4935
    URL: Article
    DOI: 10.1042/BSR20180787
    Language: English
    Publisher: Portland Press Ltd.
    Publication Date: 2019
    detail.hit.zdb_id: 2014993-1
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Valley-polarized local excitons in WSe 2 /WS 2 vertical heterostructures
    Optica Publishing Group ; 2020
    In:  Optics Express Vol. 28, No. 15 ( 2020-07-20), p. 22135-
    Details
    In: Optics Express, Optica Publishing Group, Vol. 28, No. 15 ( 2020-07-20), p. 22135-
    Abstract: Two-dimensional van der Waals heterostructures (vdWHs) are drawing growing interest in the investigation of their valley polarization properties of localized excitons. However, most of the reported vdWHs were made by micro-mechanical peeling, limiting their large-scale production and practical applications. Furthermore, the circular polarization characters of localized excitons in WSe 2 /WS 2 heterostructures remain elusive. Here, a bidirectional-flow physical vapor deposition technique was employed for the synthesis of the WSe 2 /WS 2 type-II vertical heterostructures. The interfaces of such heterojunctions are sharp and clean, making the neutral excitons of the constituent layers quenched, which significantly highlights the luminescence of the local excitons. The circular polarization of localized excitons in this WSe 2 /WS 2 heterostructure was demonstrated by circularly-polarized PL spectroscopy. The degree of the circular polarization of the localized excitons was determined as 7.17% for σ - detection and 4.78% for σ + detection. Such local excitons play a critical role in a quantum emitter with enhanced spontaneous emission rate that could lead to the evolution of LEDs. Our observations provide valuable information for the exploration of intriguing excitonic physics and the applications of innovative local exciton devices.
    Type of Medium: Online Resource
    ISSN: 1094-4087
    URL: Article
    DOI: 10.1364/OE.399142
    Language: English
    Publisher: Optica Publishing Group
    Publication Date: 2020
    detail.hit.zdb_id: 1491859-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...