In:
PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 3 ( 2023-3-16), p. e0282888-
Abstract:
Lung squamous cell carcinoma (LUSC) is the primary pathological type of lung cancer with a less favorable prognosis. This study attempts to construct a ferroptosis-associated signature associated with overall survival (OS) that can predict the prognosis of LUSC and explore its relationship with immune infiltration. A 5 ferroptosis-associated gene model was constructed by LASSO-penalized regression analysis to predict the prognosis of patients with LUSC in the TCGA database and validated in the GEO and TCGA databases. Patients were stratified into high-risk and low-risk groups by the median value of the risk scores, and the former prognosis was significantly worse (P 〈 0.001). Additionally, we found a certain association between the two risk groups and immune infiltration through CIBERSORT. Meanwhile, the differentially expressed genes (DEGs) between normal and tumor tissue were used to perform functional analysis, which showed a significant association with leukocyte transendothelial migration pathways in the TCGA cohort. In addition, immune cell infiltration analysis confirmed that M2 macrophages were significantly highly expressed in the high-risk group. Overall, the model successfully established by ferroptosis-associated genes suggests that ferroptosis may be related to immune infiltration in LUSC.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0282888
DOI:
10.1371/journal.pone.0282888.g001
DOI:
10.1371/journal.pone.0282888.g002
DOI:
10.1371/journal.pone.0282888.g003
DOI:
10.1371/journal.pone.0282888.g004
DOI:
10.1371/journal.pone.0282888.g005
DOI:
10.1371/journal.pone.0282888.g006
DOI:
10.1371/journal.pone.0282888.g007
DOI:
10.1371/journal.pone.0282888.g008
DOI:
10.1371/journal.pone.0282888.g009
DOI:
10.1371/journal.pone.0282888.g010
DOI:
10.1371/journal.pone.0282888.g011
DOI:
10.1371/journal.pone.0282888.g012
DOI:
10.1371/journal.pone.0282888.g013
DOI:
10.1371/journal.pone.0282888.t001
DOI:
10.1371/journal.pone.0282888.t002
DOI:
10.1371/journal.pone.0282888.s001
DOI:
10.1371/journal.pone.0282888.s002
DOI:
10.1371/journal.pone.0282888.s003
DOI:
10.1371/journal.pone.0282888.s004
DOI:
10.1371/journal.pone.0282888.s005
DOI:
10.1371/journal.pone.0282888.s006
DOI:
10.1371/journal.pone.0282888.s007
DOI:
10.1371/journal.pone.0282888.s008
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2267670-3
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