In:
Clinical and Applied Thrombosis/Hemostasis, SAGE Publications, Vol. 19, No. 5 ( 2013-09), p. 513-521
Abstract:
Cyclooxygenase 1 ( COX-1), COX-2, and HO-1 are involved in the process of aspirin’s effect. The genetic susceptibility of these enzymes to aspirin resistance (AR) is unclear. Methods: A total of 431 patients took aspirin. Using arachidonic acid-induced light transmittance aggregation combined with adenosine diphosphate-induced light transmittance aggregation, 36 participants served for AR, 164 participants for semi-AR, and 231 participants for aspirin sensitivity (AS). The AR with 9 single-nucleotide polymorphism in COX-1, COX-2, and HO-1 genes was investigated. Results: COX-1 rs1330344 (−1676A 〉 G) is associated with AR. G-Allele carriers significantly increased the risk of AR. For patients with AS as control, P is .02 (odds ratio [OR] = 1.77, confidence interval [CI] : 1.07-2.92). For patients with semi-AR as control, P is .05. HO-1 rs2071746 (−413A 〉 T) is associated with AR. T-Allele carriers significantly increased the risk of AR. For patients with AS as control, P is .04 (OR = 1.70, CI: 1.02-2.79). For patients with semi-AR as control, P is .05 (OR = 1.68, CI: 1.00-2.80). Conclusion: rs2071746 in HO-1 gene, rs1330344 in COX-1 gene contribute to AR.
Type of Medium:
Online Resource
ISSN:
1076-0296
,
1938-2723
DOI:
10.1177/1076029612444002
Language:
English
Publisher:
SAGE Publications
Publication Date:
2013
detail.hit.zdb_id:
2230591-9
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