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  • 1
    Online Resource
    Online Resource
    Loss-of-function variants in SEMA3F and PLXNA3 encoding semaphorin-3F and its receptor plexin-A3 respectively cause idiopathic hypogonadotropic hypogonadism
    Elsevier BV ; 2021
    In:  Genetics in Medicine Vol. 23, No. 6 ( 2021-06), p. 1008-1016
    Details
    In: Genetics in Medicine, Elsevier BV, Vol. 23, No. 6 ( 2021-06), p. 1008-1016
    Type of Medium: Online Resource
    ISSN: 1098-3600
    URL: Article
    DOI: 10.1038/s41436-020-01087-5
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2021
    detail.hit.zdb_id: 2063504-7
    SSG: 12
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  • 2
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    Long-term results of a new posterior chamber phakic intraocular lens in patients with high myopia: 5-year results
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  Journal of Cataract and Refractive Surgery Vol. 49, No. 4 ( 2023-04), p. 409-415
    Details
    In: Journal of Cataract and Refractive Surgery, Ovid Technologies (Wolters Kluwer Health), Vol. 49, No. 4 ( 2023-04), p. 409-415
    Abstract: To evaluate the long-term refractive outcomes of Eyecryl posterior chamber spherical phakic intraocular lens (pIOL) implantation in high myopia and endothelial cell density (ECD) change. Setting: Beyoglu Eye Training and Research Hospital, Istanbul, Turkey. Design: Retrospective. Methods: Eyes that were not suitable for corneal refractive surgery, had high myopia between −6.00 diopters (D) and −20.00 D, had Eyecryl posterior chamber spherical pIOL implantation, and had at least 5 years of follow-up were included. Preoperative ECD was ≥2300 cells/mm 2 and cylindrical value was ≤2.0 D in all cases. Preoperative and postoperative first, third, and fifth years of refraction, uncorrected and corrected distance visual acuity (UDVA/CDVA), and ECD were recorded. Results: 36 eyes of 18 patients were examined. The mean UDVA and CDVA in postoperative fifth years were 0.24 ± 0.19 logMAR and 0.12 ± 0.18 logMAR, respectively. The safety and efficacy indices were 1.52 ± 0.54 and 1.14 ± 0.38, respectively. At 5 years, the spherical equivalent was ±0.50 D in 75% of eyes and ±1.00 D in 92% of eyes. After 5 years, the mean cumulative ECD loss was 6.91% ( P = .07). The annual ECD loss was 1.57% in the first year, 0.26% between 1 year and 3 years, and 2.38% between 3 years and 5 years. Asymptomatic anterior capsule opacity developed in 1 eye 4 years after surgery. Rhegmatogenous retinal detachment developed in 1, and myopic choroidal neovascular membrane occurred in 1 eye. Conclusions: Eyecryl posterior chamber spherical pIOL implantation is one of the effective and safe refractive surgical methods in correcting high myopia with predictable and stable refractive results over a 5-year period. Longer-term studies are needed for complications such as decreased ECD, retinal complications, and lens opacity.
    Type of Medium: Online Resource
    ISSN: 0886-3350 , 1873-4502
    URL: Article
    DOI: 10.1097/j.jcrs.0000000000001110
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
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  • 3
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    Online Resource
    Optical coherence tomography angiography findings in optic disc drusen and idiopathic intracranial hypertension
    SAGE Publications ; 2023
    In:  European Journal of Ophthalmology
    Details
    In: European Journal of Ophthalmology, SAGE Publications
    Abstract: To evaluate the changes in peripapillary microvascularity in idiopathic intracranial hypertension (IIH) and optic disc drusen (ODD) patients, by comparing them with those in healthy individuals, via optical coherence tomography angiography (OCTA). Methods Sixty-two eyes of 33 patients with ODD, 58 eyes of 30 patients with IIH, and 70 eyes of 70 healthy people were imaged for 6 × 6-mm optic disc scans on a spectral-domain OCTA. Vascular densities in superficial capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillaris (CC) of ODD, IIH, and healthy eyes were compared with a one-way analysis of variance. Post-hoc analysis was performed with the Gabriel test. Results There was a significant decrease in peripapillary vessel density in SCP, DCP, and CC in patients with IIH compared to the control group ( p  〈  0.05). In ODD patients, especially peripapillary vessel density in DCP was significantly reduced compared to the control group ( p  〈  0.05). Peripapillary vessel density in DCP was significantly lower in the IIH group than ODD group ( p  〈  0.05). Conclusions Peripapillary vascular density may be affected during the course of the disease in both IIH and ODD. Compared to healthy individuals, the decrease in vascular density in these patients and the consequent decrease in perfusion in the peripapillary region may guide the pathogenesis of the complications in the course of these two diseases. Although vascular density in DCP and CC differs significantly between IIH and ODD, case-controlled studies are needed to evaluate the role of OCTA in the differential diagnosis of IHH and ODD.
    Type of Medium: Online Resource
    ISSN: 1120-6721 , 1724-6016
    URL: Article
    DOI: 10.1177/11206721231187664
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 1475018-1
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  • 4
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    Online Resource
    Seven-Year clinical outcomes after implantation of Eyecryl posterior chamber phakic intraocular lenses for high myopia
    SAGE Publications ; 2024
    In:  European Journal of Ophthalmology
    Details
    In: European Journal of Ophthalmology, SAGE Publications
    Abstract: To evaluate the long-term clinical outcomes, safety and efficacy of Eyecryl posterior-chamber phakic intraocular lens implantation (pIOL) implantation in patients with high myopia. Methods Patients with myopia between −6.00 and −20.00 dioptres and with endothelial cell density (ECD) was ≥2300 cells/mm 2 were included. Preoperative and postoperative first, fourth, and seventh years of refraction, uncorrected/corrected distance visual acuity (UDVA/CDVA), ECD, central vault were detected. Results Thirty-six eyes were analyzed. The mean UDVA and CDVA in postoperative seventh years were 0.25 ± 0.31 and 0.13 ± 0.24 logMAR, respectively. The safety and efficacy indices were 1.55 ± 0.54 and 1.24 ± 0.53, respectively. The mean cumulative ECD loss was 6.96% ( p 〈 0.001). The central vault at the 1 st and the 7 th year were 0.52 ± 0.14 and 0.49 ± 0.14 mm, respectively ( p = 0.25). Conclusions These findings supported the long-term stability, efficacy, safety of the Eyecryl pIOL for high myopia. Eyecryl posterior chamber pIOL is one of the effective refractive options in correcting high myopia.
    Type of Medium: Online Resource
    ISSN: 1120-6721 , 1724-6016
    URL: Article
    DOI: 10.1177/11206721241229311
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2024
    detail.hit.zdb_id: 1475018-1
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  • 5
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    Online Resource
    Optic Nerve Head, Peripapillary and Macular Microvascular Characteristics in Patients with Unilateral Pseudoexfoliation Glaucoma
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  Journal of Glaucoma
    Details
    In: Journal of Glaucoma, Ovid Technologies (Wolters Kluwer Health)
    Abstract: In unilateral pseudoexfoliation glaucoma (PEXG), there may be decreased choroidal vascularity index (CVI), radial peripapillary capillary plexus’ perfusion and flow. CVI may also be reduced in fellow eyes, suggesting that PEXG is bilateral disease. Purpose: Evaluation of peripapillary and macular choroidal microvascularity and radial peripapillary capillary plexus (RPC) in both eyes with unilateral pseudoexfoliation glaucoma (PEXG) and healthy eyes. Materials and Methods: Ninety-six eyes of 48 patients with unilateral PEXG (PEX (+): 48 eyes with PEXG; PEX (−): 48 eyes without PEX) and the right eyes of 45 age- and sex-matched healthy controls were included in the study. Choroidal vascular index (CVI) was calculated on enhanced depth imaging optical coherence tomography (EDI-OCT) scans. RPC vascular layer were evaluated by OCT-Angiography (OCTA). Results: Macular CVI (mCVI), temporal and nasal peripapillary CVI (pCVI) was significantly decreased in the PEX (+) compared to the PEX (−) and control group ( P 〈 0.05 for all). While there was a significant difference between PEX (−) and the control group in terms of mCVI and temporal pCVI, there was no significant difference between the two groups in terms of nasal pCVI ( P =0.008, P =0.036 and P =0.604, respectively). There was a significant difference in perfusion density (PD) and flux index (FI) between PEX (+) group, PEX (−) group and control group in all quadrants and average value ( P 〈 0.05 for all). Although the PD and FI values in all quadrants and average values of the PEX (−) group were lower than the control group, this difference was not significant. Conclusions: CVI in the macula and peripapillary region tends to decrease in eyes with PEXG. Similarly, PD and FI were lower in eyes with PEXG. Low mCVI and temporal pCVI can also be seen in eyes without PEX.
    Type of Medium: Online Resource
    ISSN: 1057-0829
    URL: Article
    DOI: 10.1097/IJG.0000000000002265
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    detail.hit.zdb_id: 2060541-9
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  • 6
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    The Effect of Latanoprost on Choroidal Vascularity Index in Glaucoma and Ocular Hypertension
    Ovid Technologies (Wolters Kluwer Health) ; 2022
    In:  Journal of Glaucoma Vol. 31, No. 12 ( 2022-12), p. 972-978
    Details
    In: Journal of Glaucoma, Ovid Technologies (Wolters Kluwer Health), Vol. 31, No. 12 ( 2022-12), p. 972-978
    Abstract: The choroidal vascularity index (CVI) is a new marker for the choroid. The decrease in CVI following latanoprost use can provide a better understanding of the pathogenesis of the posterior segment side effects of latanoprost such as cystoid macular edema and central serous choroidopathy. Purpose: The purpose of this paper is to evaluate the changes in the CVI, total choroidal area (TCA), stromal area (SA), luminal area (LA), and choroidal thickness (CT) following latanoprost therapy in patients with primary open angle glaucoma and ocular hypertension. Materials and Methods: Patients with newly diagnosed primary open angle glaucoma or ocular hypertension who had never received antiglaucoma therapy were included. Each patient received latanoprost 0.005% once daily. Enhanced depth imaging mode of spectral-domain optical coherence tomography scans was taken before the start of latanoprost therapy and in the first and third months. Subfoveal CT, CVI, TCA, LA, and SA for the submacular area, and 4 quadrants of the peripapillary area were calculated from the scans. Results: A total of 36 eyes of 18 patients were analyzed. Subfoveal CT increased significantly ( P =0.007). Mean TCA ( P =0.008) and SA ( P 〈 0.001) in the first and third months were higher than baseline in the submacular regions. Mean CVI was lower in the first and third months ( P 〈 0.001). There was an increase in the mean TCA and SA in the peripapillary temporal ( P =0.001 and 0.028) and inferior ( P =0.002 and 〈 0.001) quadrants and a decrease in mean CVI in the temporal ( P =0.027) and inferior ( P =0.003) peripapillary quadrants. A negative correlation was found between the rate of decrease in intraocular pressure and the macular region CVI. Conclusions: Following latanoprost use for several months, the CVI was significantly decreased in newly treated patients with glaucoma or ocular hypertension, among other changes to the choroid. These findings may contribute to a better understanding of the effects of prostaglandins on the posterior segment of the eye.
    Type of Medium: Online Resource
    ISSN: 1057-0829
    URL: Article
    DOI: 10.1097/IJG.0000000000002097
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2022
    detail.hit.zdb_id: 2060541-9
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  • 7
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    Online Resource
    Long-Term Results of Transscleral Diode Laser Cyclophotocoagulation in Glaucoma: A Real-Life Study
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  Journal of Glaucoma
    Details
    In: Journal of Glaucoma, Ovid Technologies (Wolters Kluwer Health)
    Abstract: Transscleral diode laser cyclophotocoagulation is effective and safe in a large population and different types of glaucoma, but is least effective in NVG group. Purpose: We aimed to investigate the clinical outcomes of transscleral diode laser cyclophotocoagulation (TDLC) in a large cohort of patients with different types of refractory glaucoma. Patients and Methods: Using patient charts, we retrospectively analyzed the success and complications of TDLC performed on eyes categorized in 6 groups: primary glaucoma (116 eyes), trauma (41 eyes), neovascular glaucoma (NVG, 84 eyes), post-vitreoretinal surgery (post-VRS, 79 eyes), penetrating keratoplasty (PK, 47 eyes), and miscellaneous (40 eyes). Failure was defined as intraocular pressure (IOP) 〉 22 mmHg or 〈 5 mmHg, the need for further glaucoma surgery, and the loss of light perception during follow-up. Results: Overall, the mean follow-up time was 33.4±17.4 months, the mean total energy delivered was 109.2±56.5 J, and the mean IOP reduction rate was 41.8%. Total energy delivered and IOP reduction rates were similar between the groups (all P 〉 0.05). The probability of success at 36 months was 71.5%, 70.7%, 55.9%, 77.2%, 72.3%, and 72.5% in the primary glaucoma, trauma, NVG, post-VRS, PK, and miscellaneous groups, respectively. The NVG group showed a significantly lower success rate ( P= 0.009) than the other groups. Significant complications consisted of phthisis bulbi in 1 eye (0.2%) in the NVG group and chronic hypotony in 7 eyes (1.7%) in the NVG (3 eyes), trauma (2 eyes), post-VRS (1 eye), and primary glaucoma (1 eye) groups. Conclusions: Although TDLC was found to be a safe, effective method in the long term, it was least effective in eyes with NVG.
    Type of Medium: Online Resource
    ISSN: 1057-0829
    URL: Article
    DOI: 10.1097/IJG.0000000000002346
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    detail.hit.zdb_id: 2060541-9
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  • 8
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    Online Resource
    Safety and immunogenicity of an inactivated whole virion SARS-CoV-2 vaccine, TURKOVAC, in healthy adults: Interim results from randomised, double-blind, placebo-controlled phase 1 and 2 trials
    Elsevier BV ; 2023
    In:  Vaccine Vol. 41, No. 2 ( 2023-01), p. 380-390
    Details
    In: Vaccine, Elsevier BV, Vol. 41, No. 2 ( 2023-01), p. 380-390
    Type of Medium: Online Resource
    ISSN: 0264-410X
    URL: Article
    DOI: 10.1016/j.vaccine.2022.10.093
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 1468474-3
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  • 9
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    Is There Any Correlation between Baseline Serum Cortisol Levels and Disease Severity in PCR-Positive COVID-19 Patients with and without Diabetes Mellitus?
    MDPI AG ; 2022
    In:  Vaccines Vol. 10, No. 8 ( 2022-08-20), p. 1361-
    Details
    In: Vaccines, MDPI AG, Vol. 10, No. 8 ( 2022-08-20), p. 1361-
    Abstract: Background: COVID-19 has caused a pandemic and is associated with significant mortality. The pathophysiology of COVID-19, affecting many organs and systems, is still being investigated. The hypothalamus, pituitary gland, and possibly adrenal glands are the targets of SARS-CoV-2 because of its angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) receptors expression. Hypocortisolemia can be seen in the postinfection period. COVID-19 infection tends to be severe in diabetic patients due to immune dysfunction. In this study, our aim was to investigate the relationship between basal cortisol levels and the course of COVID-19 infection in diabetic and non-diabetic patients. Methods: Our retrospective study included 311 PCR-positive COVID-19 patients over the age of 18 who were hospitalized in Ankara City Hospital Infectious Diseases Department or Intensive Care Unit (ICU) between 15 March 2020 and 15 May 2020. Serum basal cortisol, fasting plasma glucose (FPG), HbA1c values, and diabetes history were recorded within the first 24 h of hospitalization. The presence of pulmonary involvement was noted from the patients’ imaging records. Pregnant and breastfeeding women, patients with chronic liver disease or chronic kidney disease, and patients who were already using steroids or had started COVID-19 infection treatment within the 72 h before blood collection were excluded from the study. Results: Of the 311 patients, 100 had Type 2 Diabetes Mellitus (T2D), while 211 did not. The age, serum basal cortisol, and glucose levels of the patients with T2D (64.51 ± 12.29, 19.5 ± 13.12, and 143.5 (77–345)) were higher than those of the patients without T2D (46.67 ± 16.38, 15.26 ± 8.75, and 96 (65–202)), and the differences were statistically significant (p = 0.004, p = 0.004, and p 〈 0.001, respectively). The basal cortisol values of the ICU patients (27.89 (13.91–75)) were significantly higher than those of the ward patients (13.68 (1.48–51.93)) and patients who were transferred to the ICU from the ward due to worsening conditions (19.28 (7.74–55.21)) (p 〈 0.001 and p = 0.007, respectively). The factors affecting ICU admission were determined to be age, T2D history, basal cortisol, and elevation in FPG using univariate logistic regression analysis. In the multiple logistic regression analysis, age, basal cortisol level, and infiltrative involvement in thorax CT were determined to be the risk factors affecting intensive care admission. Conclusion: High basal cortisol levels in patients with T2D may predict the severity of COVID-19 infection or mortality. Although high basal cortisol levels are among the risk factors affecting ICU admission, patients with COVID-19 should also be evaluated in terms of clinical and laboratory findings and relative adrenal insufficiency.
    Type of Medium: Online Resource
    ISSN: 2076-393X
    URL: Article
    DOI: 10.3390/vaccines10081361
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2703319-3
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  • 10
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    Online Resource
    Comparison of Two Different Photorefractors with Skiascopy Measurements in Healthy Children
    Galenos Yayinevi ; 2021
    In:  Journal of Academic Research in Medicine Vol. 11, No. 2 ( 2021-8-27), p. 206-210
    Details
    In: Journal of Academic Research in Medicine, Galenos Yayinevi, Vol. 11, No. 2 ( 2021-8-27), p. 206-210
    Type of Medium: Online Resource
    ISSN: 2146-6505 , 2147-1894
    URL: Journal
    URL: Article
    DOI: 10.4274/jarem
    DOI: 10.4274/jarem.galenos.2021.87597
    Language: Unknown
    Publisher: Galenos Yayinevi
    Publication Date: 2021
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