In:
Srpski arhiv za celokupno lekarstvo, National Library of Serbia, Vol. 141, No. 3-4 ( 2013), p. 163-168
Abstract:
Introduction. Oxidative stress and antioxidants play an important role in the
pathogenesis of inflammatory disease, including chronic periodontitis (CP).
Saliva contains enzymatic (glutathione peroxidase - GPx, superoxide dismutase
- SOD, etc.) and non-enzymatic (albumin - ALB, uric acid - UA, glutathione,
etc.) antioxidants. Objective. The aims of this study were to investigate: a)
level of SOD, GPx, UA, ALB and total antioxidative status (TAS) of saliva in
CP patients before and after non-surgical treatment, and b) correlations
between clinical periodontal parameters and levels of salivary antioxidants.
Methods. Saliva was collected from 21 CP patients before and after
non-surgical treatment. The condition of periodontium was assessed by plaque
index, gingival index, bleeding on probing, probing depth and clinical
attachment loss. Level of investigated antioxidants (except GPx) and TAS was
determined using colorimetric method and commercial kits. GPx activity was
determined using UV method and commercial kits. Results. After the treatment
significant increase of UA, ALB, Gpx, TAS was detected (p〈0.01) and decrease
of SOD activity (p〉0.05). A significant correlation was observed between GPx
and PI (r=0.575, p=0.008), SOD and GI (r=0.525, p=0.017) before therapy, and
SOD and bleeding on probing (BP) (r=0.59, p=0.006), TAS and BP (r=0.453,
p=0.045) after therapy. Conclusion. These data suggest that levels of
salivary antioxidants generally increase after non-surgical periodontal
treatment. Correlation between some clinical periodontal parameters and level
of salivary antioxidants was found.
Type of Medium:
Online Resource
ISSN:
0370-8179
,
2406-0895
DOI:
10.2298/SARH1304163N
Language:
English
Publisher:
National Library of Serbia
Publication Date:
2013
detail.hit.zdb_id:
2577665-4
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