In:
FEBS Letters, Wiley, Vol. 338, No. 2 ( 1994-01-31), p. 187-190
Abstract:
Pancreatic β‐cell‐type‐specific transcription of the insulin gene is controlled by cis ‐acting sequence elements lying within its enhancer region. An essential element required for expression is the insulin control element (ICE). The activity of this element is regulated by both positive‐ and negative‐acting transcription factors. In this study, we have identified the nucleotide sequences within the ICE that are required for repression in noninsulin producing cells. Our results indicate that the cis ‐acting sequences involved in negative control are distinct from those required in activating expression in β cells.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/0014-5793(94)80362-5
Language:
English
Publisher:
Wiley
Publication Date:
1994
detail.hit.zdb_id:
1460391-3
SSG:
12
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