In:
Canadian Journal of Physiology and Pharmacology, Canadian Science Publishing, Vol. 58, No. 7 ( 1980-07-01), p. 767-771
Abstract:
Subcutaneous implantation of the transplantable pituitary tumor MtT-F 4 , which secretes large amounts of prolactin, growth hormone, and ACTH, produces hyperlipidemia in less than 30 days in the Fisher 344 rat. Further characterization of this new experimental model of endogenous hyperlipidemia showed that, at the 35th day after implantation, the hypertriglyceridemia may begin to subside while the elevation of plasma cholesterol progresses. At this time, acetate incorporation by liver slices into cholesterol is increased 27-fold while incorporation into fatty acids is 9 times as high as in sham-operated rats. Three drugs, probucol, hydroxymethylglutaric acid, and clofibrate, capable of lowering plasma cholesterol in these animals, also reduced the tumor-induced effect on cholesterol synthesis by about 60%. Only the latter two drugs, however, suppressed fatty acid synthesis to a similar extent. These experiments suggest that enhanced hepatic synthesis of cholesterol is in part responsible for the tumor-induced hypercholesterolemia.
Type of Medium:
Online Resource
ISSN:
0008-4212
,
1205-7541
Language:
English
Publisher:
Canadian Science Publishing
Publication Date:
1980
detail.hit.zdb_id:
2004356-9
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