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  • 1
    Online Resource
    Online Resource
    Ovid Technologies (Wolters Kluwer Health) ; 2001
    In:  Dermatologic Surgery Vol. 27, No. 1 ( 2001-01), p. 58-60
    In: Dermatologic Surgery, Ovid Technologies (Wolters Kluwer Health), Vol. 27, No. 1 ( 2001-01), p. 58-60
    Type of Medium: Online Resource
    ISSN: 1076-0512 , 1524-4725
    URL: Issue
    RVK:
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2001
    detail.hit.zdb_id: 2020062-6
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  • 2
    Online Resource
    Online Resource
    Fondazione Vasculab impresa sociale ONLUS ; 2023
    In:  Journal of Theoretical and Applied Vascular Research Vol. 8, No. 1 ( 2023), p. 45-46
    In: Journal of Theoretical and Applied Vascular Research, Fondazione Vasculab impresa sociale ONLUS, Vol. 8, No. 1 ( 2023), p. 45-46
    Type of Medium: Online Resource
    ISSN: 2532-0831
    URL: Issue
    Language: Unknown
    Publisher: Fondazione Vasculab impresa sociale ONLUS
    Publication Date: 2023
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  • 3
    In: Phlebology: The Journal of Venous Disease, SAGE Publications, Vol. 34, No. 2 ( 2019-03), p. 98-106
    Abstract: To compare two different medical compression stockings after varicose vein treatment. Patients and methods A randomized single-blind controlled study on two compression regimes after saphenous catheter foam sclerotherapy + phlebectomy was performed. After pads and 5 mmHg contention sock, 23 mmHg (group A, Struva 23®) or 35 mmHg (group B, Struva 35®) medical compression stocking was applied 24 h/day for seven days; subsequently 21–23 mmHg medical compression stocking in daytime. Symptoms, compliance, skin findings, and bioimpedance spectroscopy parameters were assessed. Results A total of 94 patients (48 and 49 limbs in groups A and B, respectively) were enrolled. Three (T3) and seven (T7) days post-operatively, most symptoms were significantly milder in group B, especially pain and heaviness at T7 and at day 40 (T40). Ambulation, medical compression stocking stability/tolerability and skin healing were significantly better in group B, with p = 0.046, 0.021/0.060, and 0.010, respectively, at T7. Bioimpedance parameters increased at T7 and decreased at T40 in both groups; leg reactance and limb L-Dex improved in group B at T7 and T40, respectively (p = 0.039 and 0.012). Conclusions Compression with 23 and 35 mmHg medical compression stocking after catheter foam sclerotherapy + phlebectomy was effective and well tolerated at immediate/short term. Compression with 35 mmHg medical compression stocking provided less adverse post-operative symptoms and better tissue healing. Bioimpedance results confirmed a slightly better edema improvement with 35 mmHg medical compression stocking.
    Type of Medium: Online Resource
    ISSN: 0268-3555 , 1758-1125
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 1463018-7
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  • 4
    Online Resource
    Online Resource
    Crossref ; 1999
    In:  Przegląd Flebologiczny Vol. 7, No. 2 ( 1999), p. 51-54
    In: Przegląd Flebologiczny, Crossref, Vol. 7, No. 2 ( 1999), p. 51-54
    Type of Medium: Online Resource
    ISSN: 1232-7174
    Language: Unknown
    Publisher: Crossref
    Publication Date: 1999
    detail.hit.zdb_id: 3031777-0
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  • 5
    Online Resource
    Online Resource
    Bentham Science Publishers Ltd. ; 2023
    In:  Current Aging Science Vol. 16, No. 1 ( 2023-03), p. 25-32
    In: Current Aging Science, Bentham Science Publishers Ltd., Vol. 16, No. 1 ( 2023-03), p. 25-32
    Abstract: Psycho-biological resilience is considered one of the most important factors in the epigenetics of aging. Cell senescence exhibits a series of possible biochemical derangements concerning mitochondria, proteasome, genome and membranes. Research has shown that resilience can be acquired through hormesis, a set of conservative and adaptive processes based on biphasic doseresponse to specific mild stressors, such as fasting, intake of polyphenols, exercising, physical and chemical stress and mental engagement. These stimuli were shown to elicit beneficial cellular metabolic pathways, such as sirtuin activation, mechanistic target of rapamycin and insulin growth factor- 1 downregulation, nuclear related factor 2 upregulation and autophagy. The complex of these resilience-building processes plays a documented role in longevity. Mitochondria are regarded as one of the core actors of aging processes and represent the main target of hormetic approaches [mitohormesis]; furthermore, the influence of the mind on mitochondria, and thus on the balance of health and disease has been recently established, leading to the so-called mitochondria psychobiology. Hence, psychologic and physical stress that reflects on these organelles may be regarded as a relevant factor in cell senescence, and thus the proposed “mitoresilience“ denomination may be pertinent within the biomedical science of aging. Finally, the quantification of individual resilience is becoming increasingly important in aging science, and the investigation of the autonomic nervous system through heart rate variability (HRV) proved to be a valid method to quantify this parameter. In conclusion, an integrated approach targeting hormetic pathways to improve psychophysical resilience (namely mitoresilience), supported by the monitoring of HRV, may represent a valuable option in longevity medicine.
    Type of Medium: Online Resource
    ISSN: 1874-6098
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2023
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  • 6
    Online Resource
    Online Resource
    MDPI AG ; 2020
    In:  Clinics and Practice Vol. 10, No. 2 ( 2020-05-28), p. 1271-
    In: Clinics and Practice, MDPI AG, Vol. 10, No. 2 ( 2020-05-28), p. 1271-
    Abstract: Coronavirus disease-19 (COVID-19) has been regarded as an infective-inflammatory disease, which affects mainly lungs. More recently, a multi-organ involvement has been highlighted, with different pathways of injury. A hemoglobinopathy, hypoxia and cell iron overload might have a possible additional role. Scientific literature has pointed out two potential pathophysiological mechanisms: i) severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) interaction with hemoglobin molecule, through CD147, CD26 and other receptors located on erythrocyte and/or blood cell precursors; ii) hepcidin-mimetic action of a viral spike protein, inducing ferroportin blockage. In this translational medicine-based narrative review, the following pathologic metabolic pathways, deriving from hemoglobin denaturation and iron metabolism dysregulation, are highlighted: i) decrease of functioning hemoglobin quote; ii) iron overload in cell/tissue (hyperferritinemia); iii) release of free toxic circulating heme; iv) hypoxemia and systemic hypoxia; v) reduction of nitric oxide; vi) coagulation activation; vii) ferroptosis with oxidative stress and lipoperoxidation; viii) mitochondrial degeneration and apoptosis. A few clinical syndromes may follow, such as pulmonary edema based on arterial vasoconstriction and altered alveolo-capillary barrier, sideroblastic-like anemia, endotheliitis, vasospastic acrosyndrome, and arterio- venous thromboembolism. We speculated that in COVID-19, beyond the classical pulmonary immune-inflammation view, the occurrence of an oxygen-deprived blood disease, with iron metabolism dysregulation, should be taken in consideration. A more comprehensive diagnostic/therapeutic approach to COVID-19 is proposed, including potential adjuvant interventions aimed at improving hemoglobin dysfunction, iron over-deposit and generalized hypoxic state.
    Type of Medium: Online Resource
    ISSN: 2039-7283
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2605724-4
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  • 7
    In: F1000Research, F1000 Research Ltd, Vol. 11 ( 2022-1-27), p. 102-
    Type of Medium: Online Resource
    ISSN: 2046-1402
    Language: English
    Publisher: F1000 Research Ltd
    Publication Date: 2022
    detail.hit.zdb_id: 2699932-8
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  • 8
    In: Veins and Lymphatics, PAGEPress Publications, Vol. 4, No. 1 ( 2015-04-10)
    Abstract: A prospective comparative observational study was performed to assess the short--term efficacy and safety of the peri-saphenous infiltration of tumescence solution (PST) in great saphenous vein (GSV) long catheter foam sclerotherapy (LCFS) combined with phlebectomy of the varicose tributaries. Since November 2006 through November 2010 fifty-one consecutive patients (16 males and 35 females, mean age 51.5 years) who underwent LCFS of GSV + multiple phlebectomies were prospectively enrolled, without any pre-selection criteria, in three different groups (17 patients per group) and reviewed as to their outcomes: i) patients without additional PST; ii) with PST under visual control; iii) with ultrasound-guided PST. All procedures were performed in local anesthesia and an average of 7 mL [interquartile range (IQR) 6.5-7.5] of 3% sodiumtetradecylsulfate CO2+O2-based sclerosant foam was injected in the diseased segment of GSV (median caliber 7) (IQR 6-8) by means of a 4F long catheter. Clinical and color-duplex ultrasound (CDU) follow-up was performed at regular intervals, the last of which 14 months after the treatment. At 14 months follow-up no varicose veins were visible in 94%, 94% and 100% of the cases in group I, II and III respectively. The CDUbased outcomes were the following: 71%, 71% and 84% GSV occlusion rate in group I, II and III respectively; reflux was found in 5, 4 and 1 cases in group I, II and III respectively. Clinical and CDU morphologic and hemodynamic results were assembled and scored through an arbitrary system. The relative statistical analysis showed a significant (P & lt;0.0001) improvement of the results for patients who received ultrasound guided PST over the other two groups. No relevant complications were recorded in all 51 cases. GSV treatment by means of LCFS + phlebectomy of varicose tributaries proved to be effective and safe in this prospective observational study. The addition of ultrasound guided PST resulted in a significant improvement of GSV occlusion rate and of varicose vein clinical resolution.
    Type of Medium: Online Resource
    ISSN: 2279-7483
    Language: Unknown
    Publisher: PAGEPress Publications
    Publication Date: 2015
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  • 9
    Online Resource
    Online Resource
    PAGEPress Publications ; 2019
    In:  Veins and Lymphatics Vol. 8, No. 1 ( 2019-05-13)
    In: Veins and Lymphatics, PAGEPress Publications, Vol. 8, No. 1 ( 2019-05-13)
    Abstract: Nutrition is considered a basic component in the management of any vascular disease. Lymphedema is characterised by an increase of interstitial fluid due to a lymphatic system morphological and/or functional alteration. Therapeutic management of lymphedema includes a multi-faceted approach based on compression and physiotherapy mainly. Weight control and antiinflammatory and anti-edema diet are two additional necessary components of the holistic therapy in presence of primary or secondary limb lymphedema. This narrative review provides the available information derived from the scientific literature on nutrition in lymphedema, which anyway lacks robust evidence. Additional information and speculations are provided on the role of food, diet, nutraceuticals and fasting on the basic processes at the root of the chronic progressive degeneration of tissue lymph stasis, i.e. weight excess, inflammation, edema, fibroadiposis. More targeted and randomized studies are needed in order to assess and standardise the obvious, so far neglected, role of nutrition in lymphedema patients.
    Type of Medium: Online Resource
    ISSN: 2279-7483
    Language: Unknown
    Publisher: PAGEPress Publications
    Publication Date: 2019
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  • 10
    Online Resource
    Online Resource
    PAGEPress Publications ; 2012
    In:  Veins and Lymphatics Vol. 1, No. 1 ( 2012-06-27)
    In: Veins and Lymphatics, PAGEPress Publications, Vol. 1, No. 1 ( 2012-06-27)
    Type of Medium: Online Resource
    ISSN: 2279-7483
    Language: Unknown
    Publisher: PAGEPress Publications
    Publication Date: 2012
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