In:
Histopathology, Wiley, Vol. 63, No. 4 ( 2013-10), p. 558-567
Abstract:
Mammary analogue secretory carcinoma ( MASC ) of salivary glands shows morphological similarities to milk‐secreting mammary epithelial cells. The aim of this study was to analyse the immunohistochemical expression of adipophilin (a component of milk lipid globule membranes) and of proteins related to secretory mechanisms ( STAT 5a and mammaglobin) in MASC and other salivary tumours. Methods and results Ten cases of MASC (all with ETV 6 translocation) and 83 other salivary carcinomas were studied. In all MASC cases, adipophilin stained numerous large lipid droplets. These droplets were minute in other salivary carcinomas, except for sebaceous carcinoma. Overexpression of STAT 5a was detected in all MASC cases, but only occasionally in other carcinomas. Mammaglobin expression occurred frequently in MASC (70% of cases), whereas, in other carcinomas, it was uncommon and limited. Only MASC showed cytoplasmic reactivity for p63, particularly in papillary–cystic areas. Positivity for S100, vimentin and high molecular weight keratin was observed in 100% of MASC cases. Conclusions MASC is a lipid‐rich tumour containing large lipid droplets covered by adipophilin. This finding can be included among its defining immunohistochemical features, and possibly represents lactation‐like secretory differentiation. Strong expression of STAT 5a and cytoplasmic p63 in MASC reinforces this hypothesis.
Type of Medium:
Online Resource
ISSN:
0309-0167
,
1365-2559
DOI:
10.1111/his.2013.63.issue-4
Language:
English
Publisher:
Wiley
Publication Date:
2013
detail.hit.zdb_id:
2006447-0
Permalink