In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 4 ( 2021-4-26), p. e0250254-
Abstract:
This prospective study sought to clarify the developmental endothelial locus-1 (Del-1) protein as values of diagnosis and risk stratification of prostate cancer (PCa). Design From February 2017 to December 2019, a total 458 patients who underwent transrectal ultrasound guided prostate biopsy or surgery of benign prostatic hyperplasia agreed to research of Del-1 protein. We prospectively compared and analyzed the Del-1 protein and prostate specific antigen (PSA) in relation to the patients’ demographic and clinicopathological characteristics. Results Mean age was 68.86±8.55 years. Mean PSA and Del-1 protein was 21.72±89.37, 0.099±0.145, respectively. Two hundred seventy-six (60.3%) patients were diagnosed as PCa. Among them, 181 patients underwent radical prostatectomy (RP). There were significant differences in Del-1 protein between benign and PCa group (0.066±0.131 vs 0.121±0.149, respectively, p 〈 0.001). When we set the cut-off value of del-1 protein as 0.120, in patients with 3≤PSA≤8, positive predictive value and specificity of Del-1 protein (≥0.120) for predicting PCa were 88.9% (56/63) and 93.5% (101/108), respectively. Among 181 patients who underwent RP, there were significant differences in Del-1 protein according to stage (pT2 vs pT3a vs ≥pT3b) (0.113±0.078, 0.171±0.121, 0.227±0.161, respectively, p 〈 0.001) and to Gleason score (6 (3+3) or 7 (3+4) vs 7 (4+3) or 8 (4+4) vs 9 or 10) (0.134±0.103, 0.150±0.109, 0.212±0.178, respectively, P = 0.044). Multivariate analysis showed that PSA, Del-1 protein and high Gleason score (≥9) were the independent prognostic factors for predicting higher pT stage (≥3b). Furthermore, age, PSA and Del-1 protein were independent prognostic factors for predicting significant PCa. Conclusion Patients with PCa showed higher expression of Del-1 protein than benign patients. Del-1 protein increased with the stage and Gleason score of PCa. Collaboration with PSA, Del-1 protein can be a non-invasive useful marker for diagnosis and risk stratification of PCa.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0250254
DOI:
10.1371/journal.pone.0250254.g001
DOI:
10.1371/journal.pone.0250254.g002
DOI:
10.1371/journal.pone.0250254.g003
DOI:
10.1371/journal.pone.0250254.g004
DOI:
10.1371/journal.pone.0250254.g005
DOI:
10.1371/journal.pone.0250254.g006
DOI:
10.1371/journal.pone.0250254.g007
DOI:
10.1371/journal.pone.0250254.t001
DOI:
10.1371/journal.pone.0250254.t002
DOI:
10.1371/journal.pone.0250254.t003
DOI:
10.1371/journal.pone.0250254.t004
DOI:
10.1371/journal.pone.0250254.t005
DOI:
10.1371/journal.pone.0250254.t006
DOI:
10.1371/journal.pone.0250254.t007
DOI:
10.1371/journal.pone.0250254.s001
DOI:
10.1371/journal.pone.0250254.s002
DOI:
10.1371/journal.pone.0250254.r001
DOI:
10.1371/journal.pone.0250254.r002
DOI:
10.1371/journal.pone.0250254.r003
DOI:
10.1371/journal.pone.0250254.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3
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