In:
Head & Neck, Wiley, Vol. 44, No. 11 ( 2022-11), p. 2452-2464
Abstract:
To analyze outcomes of patients treated with curative reirradiation (reRT), with intensity‐modulated radiation therapy (IMRT) or proton therapy (PT) for recurrent head and neck squamous cell carcinoma (HNSCC). Materials Among the 55 patients reirradiated for head and neck cancer from 30/08/2012 to 08/04/2019, 23 had HNSCC and received IMRT (52.2%) or PT (47.8%) at a median maximum dose to the CTV of 66 Gy. Results After a median follow‐up of 41.3 months, 18 patients developed a locoregional recurrence (LR), of which eight (44.4%) occurred within the previously reirradiated volume. Two‐year locoregional failure‐free survival and overall survival were 18.3%[95%CI:7.1%–47.1%] and 42.5%[95%CI:26.2%–69.1%] , respectively. Disease‐free survival was significantly longer in the PT group ( p = 0.031). Main late grade ≥2 toxicities were dysphagia and trismus. Conclusion Curative reRT in HNSCC is possible for selected cases, but the LR rate in the irradiated field and the risk of toxicity grade ≥2 remain high.
Type of Medium:
Online Resource
ISSN:
1043-3074
,
1097-0347
Language:
English
Publisher:
Wiley
Publication Date:
2022
detail.hit.zdb_id:
2001440-5
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