In:
Drug Intelligence & Clinical Pharmacy, SAGE Publications, Vol. 19, No. 6 ( 1985-06), p. 425-427
Abstract:
Acute anaphylactoid reactions occurred immediately after initiation of intravenous infusions of cyclosporine in three patients post-organ transplantation. Shortness of breath, flushing, tachypnea, chest pain, pruritus, or urticaria were noted; rapid recovery followed cessation of drug infusion. Subsequently, oral cyclosporine has been used in each patient without recurrence of the observed reaction. The presence of Cremophor EL as an emulsifying agent in the parenteral dosage formulation of cyclosporine is a likely etiology for this acute adverse reaction, Slowed rates of drug infusion and antihistamine premedication may permit continued intravenous cyclosporine use in affected patients.
Type of Medium:
Online Resource
ISSN:
0012-6578
DOI:
10.1177/106002808501900603
Language:
English
Publisher:
SAGE Publications
Publication Date:
1985
detail.hit.zdb_id:
2053518-1
SSG:
15,3
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