In:
PPAR Research, Hindawi Limited, Vol. 2012 ( 2012), p. 1-7
Abstract:
Emerging evidence indicates that peroxisome proliferator-activated receptor γ (PPAR γ ) and DNA methyltransferases (DNMTs) play a role in carcinogenesis. In this study we aimed to evaluate the expression of PPAR γ , DNMT1, and DNMT3B and their correlation with clinical-pathological features in patients with pancreatic cancer (PC), and to define the effect of PPAR γ activation on DNMTs expression in PC cell lines. qRT-PCR analysis showed that DNMT3B expression was downregulated in tumors compared to normal tissues (), whereas PPAR γ and DNMT1 levels did not show significant alterations in PC patients. Expression levels between PPAR γ and DNMT1 and between DNMT1 and DNMT3B were highly correlated ( and resp.). DNMT3B overexpression in tumor tissue was positively correlated with both lymph nodes spreading () and resection margin status (), and a borderline association with perineural invasion () was found. Furthermore, high levels of DNMT3B expression were significantly associated with a lower mortality in the whole population ( 95%–0.895, ) and in the subgroup of patients without perineural invasion (; 95%–0.758; ), while such association was not observed in patients with tumor invasion into perineural structures (). In conclusion, in vitro and in vivo PPAR γ and DNMTs appear interrelated in PC, and this interaction might influence cell phenotype and disease behavior.
Type of Medium:
Online Resource
ISSN:
1687-4757
,
1687-4765
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2012
detail.hit.zdb_id:
2237981-2
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