In:
American Journal of Veterinary Research, American Veterinary Medical Association (AVMA), Vol. 66, No. 7 ( 2005-07-01), p. 1222-1226
Abstract:
Objective —To determine the hemodynamic consequences
of the coadministration of a continuous rate infusion (CRI) of medetomidine with a fentanyl bolus
in dogs. Animals —12 healthy sexually intact male dogs
weighing 30.3 ± 4.2 kg (mean ± SD). Procedure —Dogs received either fentanyl alone (15.0
µg/kg, IV bolus) or the same dose of fentanyl during an 11-hour CRI of medetomidine (1.5 µg/kg/h, IV). Prior to
drug administration, dogs were instrumented for measurement of cardiac output, left atrial pressure, and
systemic arterial blood pressures. Additionally, blood samples were collected from the pulmonary artery
and left atrium for blood gas analysis. Results —Medetomidine infusion reduced the cardiac
index, heart rate, and O 2 delivery while increasing left
atrial pressure. Subsequent fentanyl administration further decreased the cardiac index. The PaO 2 was not
significantly different between the 2 treatment groups; however, fentanyl transiently decreased PaO 2 from baseline values in dogs receiving a CRI of
medetomidine. Conclusions and Clinical Relevance —Because of
the prolonged hemodynamic changes associated with the CRI of medetomidine, its safety should be
further evaluated before being clinically implemented in dogs. ( Am J Vet Res 2005;66:1222–1226)
Type of Medium:
Online Resource
ISSN:
0002-9645
DOI:
10.2460/ajvr.2005.66.1222
Language:
Unknown
Publisher:
American Veterinary Medical Association (AVMA)
Publication Date:
2005
detail.hit.zdb_id:
2056942-7
SSG:
22
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