In:
European Respiratory Journal, European Respiratory Society (ERS), Vol. 51, No. 2 ( 2018-02), p. 1701488-
Kurzfassung:
There is limited high-quality evidence available to inform the use of text messaging to improve latent tuberculosis infection (LTBI) treatment adherence. We performed a parallel, randomised controlled trial at two sites to assess the effect of a two-way short message service on LTBI adherence. We enrolled adults initiating LTBI therapy from June 2012 to September 2015 in British Columbia, Canada. Participants were randomised in a 1:1 ratio to standard LTBI treatment (control) or standard LTBI treatment plus two-way weekly text messaging (intervention). The primary outcome was treatment completion, defined as taking ≥80% prescribed doses within 12 months (isoniazid) or 6 months (rifampin) of enrolment. The trial was unblinded except for the data analyst. A total of 358 participants were assigned to the intervention (n=170) and control (n=188) arms. In intention-to-treat analysis, the proportion of participants completing LTBI therapy in the intervention and control arms was 79.4% and 81.9%, respectively (RR 0.97, 95% CI 0.88–1.07; p=0.550). Results were similar for pre-specified secondary end-points, including time-to-completion of LTBI therapy, completion of 〉 90% of prescribed LTBI doses and health-related quality of life. Weekly two-way text messaging did not improve LTBI completion rates compared to standard LTBI care; however, completion rates were high in both treatment arms.
Materialart:
Online-Ressource
ISSN:
0903-1936
,
1399-3003
DOI:
10.1183/13993003.01488-2017
DOI:
10.1183/13993003.01488-2017.Supp1
DOI:
10.1183/13993003.01488-2017.Supp2
Sprache:
Englisch
Verlag:
European Respiratory Society (ERS)
Publikationsdatum:
2018
ZDB Id:
2834928-3
ZDB Id:
1499101-9
Permalink