GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    Potential prophylactic value of bovine colostrum in necrotizing enterocolitis in neonates: an in vitro study on bacterial attachment, antibody levels and cytokine production
    Oxford University Press (OUP) ; 2006
    In:  FEMS Immunology & Medical Microbiology Vol. 48, No. 3 ( 2006-12), p. 347-354
    Details
    In: FEMS Immunology & Medical Microbiology, Oxford University Press (OUP), Vol. 48, No. 3 ( 2006-12), p. 347-354
    Type of Medium: Online Resource
    ISSN: 0928-8244 , 1574-695X
    URL: Issue
    URL: Article
    DOI: 10.1111/fim.2006.48.issue-3
    DOI: 10.1111/j.1574-695X.2006.00151.x
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2006
    detail.hit.zdb_id: 2693712-8
    detail.hit.zdb_id: 1500464-8
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    The Response of Human Peripheral Blood Mononuclear Phagocytes to Rheumatoid Arthritis
    Oxford University Press (OUP) ; 1985
    In:  Journal of Leukocyte Biology Vol. 37, No. 2 ( 1985-02-01), p. 221-230
    Details
    In: Journal of Leukocyte Biology, Oxford University Press (OUP), Vol. 37, No. 2 ( 1985-02-01), p. 221-230
    Abstract: The maturity of peripheral blood mononuclear phagocytes (B-MPs) from patients with rheumatoid arthritis (RA), osteoarthritis (OA), and reference (“normal”) subjects was compared. Mononuclear cell isolates from peripheral blood were separated on discontinuous gradients of Percoll into low density (more mature) and high density (less mature) subpopulations. Contrary to expectations, the proportion of immature B-MPs in RA patients was found to be significantly lower than that in reference subjects. In RA patients with synovial effusions the proportion of immature B-MPs approached but did not exceed those found in reference subjects, despite the fact that 31% of these patients displayed a peripheral blood monocytosis. It was concluded that the bone marrow precursor population had adapted to the long-term demand for B-MPs in the course of this chronic inflammatory disease.
    Type of Medium: Online Resource
    ISSN: 0741-5400 , 1938-3673
    URL: Article
    DOI: 10.1002/jlb.37.2.221
    RVK:
    XA 10000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 1985
    detail.hit.zdb_id: 2026833-6
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma
    Springer Science and Business Media LLC ; 2019
    In:  Nature Communications Vol. 10, No. 1 ( 2019-06-03)
    Details
    In: Nature Communications, Springer Science and Business Media LLC, Vol. 10, No. 1 ( 2019-06-03)
    Abstract: BET-bromodomain inhibition (BETi) has shown pre-clinical promise for MYC-amplified medulloblastoma. However, the mechanisms for its action, and ultimately for resistance, have not been fully defined. Here, using a combination of expression profiling, genome-scale CRISPR/Cas9-mediated loss of function and ORF/cDNA driven rescue screens, and cell-based models of spontaneous resistance, we identify bHLH/homeobox transcription factors and cell-cycle regulators as key genes mediating BETi’s response and resistance. Cells that acquire drug tolerance exhibit a more neuronally differentiated cell-state and expression of lineage-specific bHLH/homeobox transcription factors. However, they do not terminally differentiate, maintain expression of CCND2, and continue to cycle through S-phase. Moreover, CDK4/CDK6 inhibition delays acquisition of resistance. Therefore, our data provide insights about the mechanisms underlying BETi effects and the appearance of resistance and support the therapeutic use of combined cell-cycle inhibitors with BETi in MYC-amplified medulloblastoma.
    Type of Medium: Online Resource
    ISSN: 2041-1723
    URL: Article
    DOI: 10.1038/s41467-019-10307-9
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2019
    detail.hit.zdb_id: 2553671-0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Strains of Mycobacterium avium differentially activate human dendritic cells
    Wiley ; 2010
    In:  Immunology & Cell Biology Vol. 88, No. 1 ( 2010-01), p. 95-98
    Details
    In: Immunology & Cell Biology, Wiley, Vol. 88, No. 1 ( 2010-01), p. 95-98
    Abstract: Animal models indicate that exposure to environmental strains of mycobacteria can modulate immune responses and influence the effectiveness of live mycobacterial vaccines. Here, we describe that between the two recently reported Mycobacterium avium isolates, strain WAg 206 (but not strain WAg 207) interferes with human monocyte‐derived dendritic cell (MDDC) activation. WAg 206, unlike WAg 207, did not elicit inflammatory cytokine production (TNFα, IL‐1β, IL‐12) or costimulatory molecule expression (HLA‐DR, CD83, CD80, CD86) by human MDDCs in vitro . These data highlight the potential for environmental mycobacteria to modulate immune responses in humans, and suggest a mechanism by which earlier exposure to such microbes may compromise the efficacy of live mycobacterial vaccines, as has been observed in some human BCG vaccine trials.
    Type of Medium: Online Resource
    ISSN: 0818-9641 , 1440-1711
    URL: Article
    DOI: 10.1038/icb.2009.51
    Language: English
    Publisher: Wiley
    Publication Date: 2010
    detail.hit.zdb_id: 2011707-3
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Immunogenicity and protective efficacy of mycobacterial DNA vaccines incorporating plasmid‐encoded cytokines against Mycobacterium bovis
    Wiley ; 2010
    In:  Immunology & Cell Biology Vol. 88, No. 6 ( 2010-08), p. 651-657
    Details
    In: Immunology & Cell Biology, Wiley, Vol. 88, No. 6 ( 2010-08), p. 651-657
    Abstract: DNA‐based vaccines, alone or in combination with other sub‐unit vaccination regimes, represent an alternative to live mycobacterial vaccines for protective immunization against tuberculosis. Here, we have used a murine immunization or Mycobacteriam bovis aerosol challenge model to assess the immunogenicity and protective efficacy of mycobacterial DNA vaccines. Mice that received immunization with DNA constructs encoding M. bovis antigen 85A (Ag85–A) and arget(ESAT‐6) produced measurable interferon‐gamma (IFN‐γ) responses to CD4 + T‐cell epitope‐peptide recall antigens in vitro . The magnitude of these responses was enhanced by co‐delivery of a construct encoding murine cytokines (macrophage inhibitory protein (MIP)‐1α or interleukin(IL)‐7), although they did not the match responses observed in mice that received Bacille Calmette−Guerin(BCG) immunisation. In contrast, DNA priming followed by boosting with modified vaccinia Ankara (MVA) vaccine (expressing M. tuberculosis Ag85–A) invoked higher IFN‐γ levels, with the most immunogenic regime of Ag85 or ESAT or IL‐7 prime followed by MVA boost being of commensurate immunogenicity to BCG. Despite this, neither DNA alone nor DNA‐prime or MVA boost regimes conferred measurable protection against aerosol challenge with virulent M. bovis . These data highlight both the promise and the shortcomings of new generation subunit tuberculosis vaccines, with particular emphasis on their potential as vaccines against M. bovis .
    Type of Medium: Online Resource
    ISSN: 0818-9641 , 1440-1711
    URL: Article
    DOI: 10.1038/icb.2010.25
    Language: English
    Publisher: Wiley
    Publication Date: 2010
    detail.hit.zdb_id: 2011707-3
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Oral vaccination of mice with lipid‐encapsulated Mycobacterium bovis BCG: Anatomical sites of bacterial replication and immune activity
    Wiley ; 2005
    In:  Immunology & Cell Biology Vol. 83, No. 5 ( 2005-10), p. 549-553
    Details
    In: Immunology & Cell Biology, Wiley, Vol. 83, No. 5 ( 2005-10), p. 549-553
    Abstract: Lipid microencapsulation of Mycobacterium bovis bacille Calmette–Guérin (BCG) produces an oral delivery vaccine that can establish systemic cell‐mediated immune reactivity and protection against aerosol mycobacterial challenge in mice. Here, we describe the lymphatic and mucosal sites of bacterial replication, and location of Mycobacterium ‐specific IFN‐γ‐secreting cell populations, following oral vaccination of BALB/c mice. Eight weeks following a single oral dose of lipid‐encapsulated BCG, viable BCG organisms were recovered from the mesenteric lymph nodes (MLN) of 11/12 mice investigated (93%). Live bacteria were also occasionally recovered from the cervical lymph nodes (17%) and Peyer's patches (8%), but not from homogenates of the lungs or spleen. Strong Mycobacterium ‐specific IFN‐γ production was recorded among isolated splenocytes, but not among populations of mononuclear cells derived from the MLN or lungs. Oral vaccination of mice with lipid‐encapsulated BCG thus appears to promote a state of systemic immunological reactivity more akin to that observed following parenteral rather than conventional oral vaccination, despite the fact that replicating bacilli are restricted to lymphatic tissues of the alimentary tract. Possible patterns of lymphocyte sensitization and trafficking are discussed.
    Type of Medium: Online Resource
    ISSN: 0818-9641 , 1440-1711
    URL: Issue
    URL: Article
    DOI: 10.1111/imcb.2005.83.issue-5
    DOI: 10.1111/j.1440-1711.2005.01369.x
    Language: English
    Publisher: Wiley
    Publication Date: 2005
    detail.hit.zdb_id: 2011707-3
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    BCG vaccination in deer: Distinctions between delayed type hypersensitivity and laboratory parameters of immunity
    Wiley ; 1993
    In:  Immunology & Cell Biology Vol. 71, No. 6 ( 1993-12), p. 559-570
    Details
    In: Immunology & Cell Biology, Wiley, Vol. 71, No. 6 ( 1993-12), p. 559-570
    Abstract: Groups of deer were vaccinated with live or killed Bacillus Calmette‐Guerin (BCG), with and without oil adjuvant, to compare their immune responses with those found in naturally infected animals. Killed BCG in oil induced strong lymphocyte transformation (LT) and antibody (ELISA) responses specific for Mycobacterium bovis antigens. Serum inflammatory proteins (SIP) were also induced after these animals were skin tested. This pattern of reactivity mirrored that found in naturally infected deer with active tuberculosis. Animals vaccinated with live BCG without oil adjuvant also produced strong LT reactivity hut this was directed at common mycobacterial antigens found on both M. bovis and M. avium , although no antibody or SIP were detected at any stage of the experiment. The pattern of immune responsiveness to live BCG was similar to that found in naturally infected, but non‐diseased deer, and may represent the immunoprotective response to tuberculosis. Significant differences in specificity of lymphocyte transformation and intradermal skin test reactivity to mycobacterial antigens were also identified. Vaccination with BCG in various formulations provides an experimental probe to evaluate the immunological hasis of immunity to tuberculosis.
    Type of Medium: Online Resource
    ISSN: 0818-9641 , 1440-1711
    URL: Article
    DOI: 10.1038/icb.1993.62
    Language: English
    Publisher: Wiley
    Publication Date: 1993
    detail.hit.zdb_id: 2011707-3
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Environmental Strains of Mycobacterium avium Interfere with Immune Responses Associated with Mycobacterium bovis BCG Vaccination
    American Society for Microbiology ; 2007
    In:  Infection and Immunity Vol. 75, No. 6 ( 2007-06), p. 2833-2840
    Details
    In: Infection and Immunity, American Society for Microbiology, Vol. 75, No. 6 ( 2007-06), p. 2833-2840
    Abstract: Prior exposure of a vaccinee to certain species of environmental mycobacteria can prime the immune system against common mycobacterial antigens, which can in turn reduce the subsequent efficacy of live attenuated mycobacterial vaccines (such as Mycobacterium bovis BCG), in both human and livestock vaccination programs. In this study, two strains of Mycobacterium avium , both isolated from New Zealand livestock, were investigated to determine their growth characteristics and effects on the immune system in murine models. Markedly different effects on the immune system were observed; an IS 901 -negative strain (WAg 207) induced significant up-regulation of cell surface activation markers (major histocompatibility complex II, CD80, and CD86) on in vitro-derived dendritic cells and induced the release of proinflammatory monokines (interleukin-1β [IL-1β], IL-6, and tumor necrosis factor alpha) in dendritic cell-macrophage cocultures following direct in vitro contact of cells with bacteria. In contrast, an IS 901 -positive strain (WAg 206) had none of these effects. When mice were exposed to M. avium via oral infection prior to BCG parenteral immunization, both strains were shown to be capable of decreasing subsequent antigen-stimulated gamma interferon secretion by splenic lymphocytes, although this effect was more significant for strain WAg 206. Both strains also induced a mycobacterial antigen-specific serological response in M. avium -sensitized and BCG-immunized mice; this response was greater in WAg 206-sensitized mice, and there was a predominance of immunoglobulin G1 antibody. The down-regulation of IFN-γ responses and the up-regulation of antibody responses are characteristic of a switch to a type 2 immune response. The different results may be linked to the inherent growth characteristics of the two strains, since WAg 206 was shown to grow slowly in murine macrophages in vitro and to cause a persistent systemic infection following infection in vivo, while WAg 207 grew fast and did not persist in mice. The implications of these findings for BCG vaccination protocols are discussed.
    Type of Medium: Online Resource
    ISSN: 0019-9567 , 1098-5522
    URL: Article
    DOI: 10.1128/IAI.01826-06
    RVK:
    XA 10000
    Language: English
    Publisher: American Society for Microbiology
    Publication Date: 2007
    detail.hit.zdb_id: 1483247-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    T cell responses to Mycobacterium bovis , in red deer, a large animal model for tuberculosis
    Wiley ; 1996
    In:  Immunology & Cell Biology Vol. 74, No. 1 ( 1996-02), p. 32-37
    Details
    In: Immunology & Cell Biology, Wiley, Vol. 74, No. 1 ( 1996-02), p. 32-37
    Abstract: Red deer ( Cervus elaphus ) represent an appropriate large animal model to study the immunology of tuberculosis, being naturally susceptible to Mycobacterium bovis infection. Cell‐mediated immune responses were investigated in deer displaying protective‐ or disease‐type reactions, following immunization with M. bovis bacille Calmette‐Guerin (BCG) or infection with virulent M. bovis , respectively. T cell responses were measured as antigen‐dependent cell proliferation and production of T cell growth factor (TCGF) following in vitro stimulation with M. bovis antigens (live or heat‐killed BCG, or PPD). T cells from immunized deer proliferated less in response to soluble denatured culture antigen (purified protein derivative, PPD) than to particulate BCG, although there were no differences in the magnitude of these responses between the two groups of animals. Cells derived from immunized deer produced less TCGF than cells from infected deer when stimulated with PPD in vitro , although responses to BCG antigens were similar between the two groups. The majority of TCGF activity was neutralized by anti‐IL‐2 antibodies, regardless of the animal group or source of antigen used for in vitro stimulation. After 7 days in vitro culture with antigen, blast cells staining positively for αβ (CD4. CD8) and γδ T cell receptors were recorded. The majority of blasts were CD4 + , although in immunized deer fewer CD4 + blasts were produced following in vitro stimulation with PPD than with BCG antigens. These results, together with previous reports from our laboratory, represent the only detailed examinations of T cell responses to M. bovis in this naturally‐susceptible ruminant species.
    Type of Medium: Online Resource
    ISSN: 0818-9641 , 1440-1711
    URL: Article
    DOI: 10.1038/icb.1996.4
    Language: English
    Publisher: Wiley
    Publication Date: 1996
    detail.hit.zdb_id: 2011707-3
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Vaccination against tuberculosis: Is BCG more sinned against than sinner?
    Wiley ; 1993
    In:  Immunology & Cell Biology Vol. 71, No. 5 ( 1993-10), p. 431-442
    Details
    In: Immunology & Cell Biology, Wiley, Vol. 71, No. 5 ( 1993-10), p. 431-442
    Abstract: While extensive experimental studies of tuberculosis (Tb) have provided the foundation data for the discovery of cell‐mediated immunity, there remains much to be disclosed about the critical pathways of immunity involved in this infectious process and the factors necessary to produce protective immunity. Studies on the actiology and pathology of this disease have failed to elucidate the mechanisms of protective immunity. Although Tb research has been neglected for the past 30 years, the re‐emergence of Tb worldwide as a significant zoonotic disease has re‐focused research in this area. Scientific solutions for the control of Tb in man or domestic animals have not been found using empirical methods. Composite studies involving animal models of experimental infection will be necessary to critically evaluate vaccine efficacy and elucidate the basic immunological mechanisms involved in both disease and immunity. Available data which suggest that disease‐related hypersensitivity and immunity are dissociable highlight the prospect that immunity to infection may be induced without compromising the continued need for ongoing systems of immunodiagnosis to exclude disease. In populations with a high prevalence of disease it is likely that a combination of immunodiagnosis, chemotherapy and immunoprophylaxis will be required to eradicate the disease.
    Type of Medium: Online Resource
    ISSN: 0818-9641 , 1440-1711
    URL: Article
    DOI: 10.1038/icb.1993.49
    Language: English
    Publisher: Wiley
    Publication Date: 1993
    detail.hit.zdb_id: 2011707-3
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...