In:
European Journal of Clinical Investigation, Wiley, Vol. 47, No. 12 ( 2017-12)
Abstract:
Right heart catheterization ( RHC ) is usually required to confirm the diagnosis of pulmonary artery hypertension ( PAH ). As an invasive test, RHC may be associated with possible complications, so noninvasive parameters able to predict PAH at RHC would be extremely useful. Aim To ascertain possible correlations between cardiopulmonary exercise testing ( CPET ) and hemodynamic parameters at RHC indicative of pulmonary hypertension ( PH ). Methods Thirty‐six consecutive outpatients with suspect of PAH underwent CPET and RHC ; the intercept of ventilation (VEint) on the VE vs carbon dioxide production ( VE / VCO 2 ) and VE / VCO 2 slope at CPET and diastolic pressure gradient ( DPG ), trans‐pulmonary pressure gradient ( TPG ), mean pulmonary artery pressure ( mPAP ) and pulmonary vascular resistance ( PVR ) at RHC were assessed and compared. Results Ventilation VCO 2 slope was directly related to DPG ( r : .41, P : .019), TPG ( r : .45, P : .01), mean pulmonary arterial pressure ( mPAP , r : .36, P : .031), PVR ( r : .41, P : .029), VE int and VE / VCO 2 slope inversely related to DPG ( r : −.63, P 〈 .001), TPG ( r : −.67, P 〈 .001), mPAP ( r : −.68, P 〈 .001) and PVR ( r : −.5, P 〈 .001). Conclusion In patients with suspected PAH , VE int during exercise and the VE / VCO 2 slope might provide useful information to predict results of RHC . Their correlations with PVR and with DPG may be helpful in discriminating patients with isolated postcapillary PH from those with combined postcapillary and precapillary.
Type of Medium:
Online Resource
ISSN:
0014-2972
,
1365-2362
DOI:
10.1111/eci.2017.47.issue-12
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2004971-7
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