In:
Pathobiology, S. Karger AG, Vol. 87, No. 6 ( 2020), p. 367-374
Kurzfassung:
〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 There is some evidence suggesting a link between 〈 i 〉 BRCA1/2 〈 /i 〉 germline mutations and increased risk of gastric cancer. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Endoscopic screening for stomach malignancies was performed in 120 〈 i 〉 BRCA1 〈 /i 〉 mutation carriers in order to evaluate the probability of detecting the tumor disease. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 No instances of gastric cancer were revealed at the first visit. The analysis of atrophic changes performed by OLGA (Operative Link for Gastritis Assessment) criteria revealed that OLGA stages I–IV alterations were observed in 26 of 41 (63%) subjects aged & #x3e;50 years as compared to 29 of 79 (37%) in younger subjects ( 〈 i 〉 p 〈 /i 〉 = 0.007, χ 〈 sup 〉 2 〈 /sup 〉 test). One 〈 i 〉 BRCA1 〈 /i 〉 mutation carrier developed gastric cancer 4 years after the first visit for endoscopic examination. We performed next-generation sequencing analysis for this tumor and additional 4 archival gastric cancers obtained from 〈 i 〉 BRCA1/2 〈 /i 〉 mutation carriers. Somatic loss of the remaining 〈 i 〉 BRCA1/2 〈 /i 〉 allele was observed in 3 out of 5 tumors analyzed; all of these carcinomas, but none of the malignancies with the retained 〈 i 〉 BRCA1/2 〈 /i 〉 copy, showed chromosomal instability. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Taken together, these data justify further studies on the relationships between the 〈 i 〉 BRCA1/2 〈 /i 〉 and gastric cancer.
Materialart:
Online-Ressource
ISSN:
1015-2008
,
1423-0291
Sprache:
Englisch
Verlag:
S. Karger AG
Publikationsdatum:
2020
ZDB Id:
1483541-1
SSG:
12
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