In:
PLOS Neglected Tropical Diseases, Public Library of Science (PLoS), Vol. 15, No. 1 ( 2021-1-20), p. e0009052-
Abstract:
Intestinal helminth infection can impair host resistance to co-infection with enteric bacterial pathogens. However, it is not known whether helminth drug-clearance can restore host resistance to bacterial infection. Using a mouse helminth- Salmonella co-infection system, we show that anthelmintic treatment prior to Salmonella challenge is sufficient to restore host resistance to Salmonella . The presence of the small intestine-dwelling helminth Heligmosomoides polygyrus at the point of Salmonella infection supports the initial establishment of Salmonella in the small intestinal lumen. Interestingly, if helminth drug-clearance is delayed until Salmonella has already established in the small intestinal lumen, anthelmintic treatment does not result in complete clearance of Salmonella . This suggests that while the presence of helminths supports initial Salmonella colonization, helminths are dispensable for Salmonella persistence in the host small intestine. These data contribute to the mechanistic understanding of how an ongoing or prior helminth infection can affect pathogenic bacterial colonization and persistence in the mammalian intestine.
Type of Medium:
Online Resource
ISSN:
1935-2735
DOI:
10.1371/journal.pntd.0009052
DOI:
10.1371/journal.pntd.0009052.g001
DOI:
10.1371/journal.pntd.0009052.g002
DOI:
10.1371/journal.pntd.0009052.g003
DOI:
10.1371/journal.pntd.0009052.g004
DOI:
10.1371/journal.pntd.0009052.s001
DOI:
10.1371/journal.pntd.0009052.s002
DOI:
10.1371/journal.pntd.0009052.s003
DOI:
10.1371/journal.pntd.0009052.s004
DOI:
10.1371/journal.pntd.0009052.s005
DOI:
10.1371/journal.pntd.0009052.s006
DOI:
10.1371/journal.pntd.0009052.s007
DOI:
10.1371/journal.pntd.0009052.s008
DOI:
10.1371/journal.pntd.0009052.s009
DOI:
10.1371/journal.pntd.0009052.s010
DOI:
10.1371/journal.pntd.0009052.s011
DOI:
10.1371/journal.pntd.0009052.r001
DOI:
10.1371/journal.pntd.0009052.r002
DOI:
10.1371/journal.pntd.0009052.r003
DOI:
10.1371/journal.pntd.0009052.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2429704-5
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