In:
Acta Endocrinologica, Oxford University Press (OUP), Vol. 58, No. 4 ( 1968-08), p. 673-684
Abstract:
To each of two male subjects, 10 mg of 16-oxo-oestrone was administered intramuscularly. By various microchemical reactions, the following phenolic steroids were identified in urine: oestriol, 16- epi -oestriol, 16-oxo-17β-oestradiol, 16α-hydroxyoestrone, 16β-hydroxyoestrone, 17- epi -oestriol and 16,17- epi -oestriol. Calculated on the basis of the administered amount of 16-oxo-oestrone, the average total excretion during the 5 days of the experiment was 12% for oestriol, 3.9% for 16- epi -oestriol, 2.9% for 16-oxo-17β-oestradiol, 1.5% for 16α-hydroxyoestrone, 0.7% for 16β-hydroxyoestrone, 0.6% for 17- epi -oestriol and 0.3% for 16,17- epi -oestriol. These results confirm previous experiments with human liver slices and show that, in addition to 17β-, 16α- and 16β-hydroxysteroid oxidoreductases, a 17α-hydroxysteroid oxidoreductase is present in man which reacts with phenolic steroids. The total recoveries of all reduction products of 16-oxo-oestrone were 26% for subject A and 18% for subject B. These relatively low values suggest that 16-oxo-oestrone is subjected in man not only to a reduction but also to an oxidative metabolism which may be of quantitative significance.
Type of Medium:
Online Resource
ISSN:
0804-4643
,
1479-683X
DOI:
10.1530/acta.0.0580673
Language:
Unknown
Publisher:
Oxford University Press (OUP)
Publication Date:
1968
detail.hit.zdb_id:
1183856-5
detail.hit.zdb_id:
1485160-X
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