In:
Journal of Virology, American Society for Microbiology, Vol. 74, No. 20 ( 2000-10-15), p. 9762-9765
Abstract:
Optimal expansion of influenza virus nucleoprotein (D b NP 366 )-specific CD8 + T cells following respiratory challenge of naive Ig −/− μMT mice was found to require CD4 + T-cell help, and this effect was also observed in primed animals. Absence of the CD4 + population was consistently correlated with diminished recruitment of virus-specific CD8 + T cells to the infected lung, delayed virus clearance, and increased morbidity. The splenic CD8 + set generated during the recall response in Ig −/− mice primed at least 6 months previously showed a normal profile of gamma interferon production subsequent to short-term, in vitro stimulation with viral peptide, irrespective of a concurrent CD4 + T-cell response. Both the magnitude and the localization profiles of virus-specific CD8 + T cells, though perhaps not their functional characteristics, are thus modified in mice lacking CD4 + T cells.
Type of Medium:
Online Resource
ISSN:
0022-538X
,
1098-5514
DOI:
10.1128/JVI.74.20.9762-9765.2000
Language:
English
Publisher:
American Society for Microbiology
Publication Date:
2000
detail.hit.zdb_id:
1495529-5
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