In:
Pediatrics, American Academy of Pediatrics (AAP), Vol. 25, No. 5 ( 1960-05-01), p. 859-868
Abstract:
Newborn lambs were delivered by hysterotomy, their respiratory passages occluded, and their umbilical cords ligated. Blood pressure in the aorta and a lead II electrocardiogram were continuously recorded, and periodic blood samples were obtained as the animals were allowed to become severely anoxic. Intra-aortic pressure transfusion of oxygenated blood brought about only a transient elevation of the ventricular rate and systolic pressure. Subsequent application of endotracheal insufflation of oxygen under pressure produced striking and more sustained improvement. The acidosis and lactic acidemia which developed during the anoxic state were never fully corrected, and the condition of all of the animals eventually deteriorated. Of particular interest was the reduction in concentration of pyruvate in the blood during severe anoxia and its subsequent return to pre-anoxia levels after instituting artificial respiration.
Type of Medium:
Online Resource
ISSN:
0031-4005
,
1098-4275
DOI:
10.1542/peds.25.5.859
Language:
English
Publisher:
American Academy of Pediatrics (AAP)
Publication Date:
1960
detail.hit.zdb_id:
1477004-0
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