In:
Archiv der Pharmazie, Wiley, Vol. 343, No. 10 ( 2010-10), p. 570-576
Abstract:
Quinazoline derivatives are reported to have anti‐inflammatory, analgesic, antibacterial, and anticancer activities. The incorporation of “OCH 2 CONH 2 ” (oxymethylcarbamide) at 4 th position of the quinazoline ring was found to influence the biological activities of the molecules. With this rationale, some new oxadiazolyl methyloxy quinazolines, pyrazolyl acetoxy methyl quinazolines, triazolylmethyloxy quinazolines were synthesized from anthranilic acid through quinazolyl oxyacetylhydrazide intermediates. All the compounds were characterized by IR, 1 H‐NMR, EI‐MS, and C, H, N analyses and evaluated for their antimicrobial activity. Docking studies on the DNA‐gyrase enzyme (1KZN) show their role in the antimicrobial activity of the molecules and explain the higher potency of compounds 6a , 6b , 8a , 8b based on ReRanking scores and binding poses of the molecules.
Type of Medium:
Online Resource
ISSN:
0365-6233
,
1521-4184
DOI:
10.1002/ardp.v343:10
DOI:
10.1002/ardp.201000065
Language:
English
Publisher:
Wiley
Publication Date:
2010
detail.hit.zdb_id:
1496815-0
SSG:
15,3
Permalink