In:
Science, American Association for the Advancement of Science (AAAS), Vol. 375, No. 6580 ( 2022-02-04), p. 494-495
Abstract:
Adenine methylation, forming N 6 -methyl-2′-deoxyadenosine (6mA), is a prevalent DNA modification in prokaryotes and has recently been proposed to exist in multicellular eukaryotes (metazoans) to regulate diverse processes, including transcription, stress responses, and tumorigenesis. However, the existence of 6mA, and therefore its biological importance, in metazoan DNA has been debated by recent studies, which have either detected 6mA at much lower abundances than initially reported or failed to detect 6mA at all. On page 515 of this issue, Kong et al. ( 1 ) report the development of 6mASCOPE, a quantitative method that deconvolutes 6mA in samples of interest from contamination sources. They detected low amounts of 6mA in fruit flies ( Drosophila melanogaster ), plants ( Arabidopsis thaliana ), and humans, which suggests that 6mA is much less abundant in these organisms than previously thought. These data suggest that a reassessment of 6mA in eukaryotic DNA is warranted.
Type of Medium:
Online Resource
ISSN:
0036-8075
,
1095-9203
DOI:
10.1126/science.abn6514
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2022
detail.hit.zdb_id:
128410-1
detail.hit.zdb_id:
2066996-3
detail.hit.zdb_id:
2060783-0
SSG:
11
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