In:
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, Connect Journals, Vol. 33, No. 04 ( 2023-12), p. 405-
Abstract:
Treatment of starting quinoline-3-carbaldehyde 1 with acetophenones 2a-d gave the chalcone 3. The latter compounds, on cyclization, gave the pyrazoloquinolinol derivatives 4a-d after their treatment with benzohydrazide. Quinoline-3-carbaldehyde (1) reacted with cyclohexane-1,3-dione and either malononitrils (6a) or ethyl cyanoacetate (6b) in ethanol containing a catalytic amount of trimethylamine to give the chromenopyranoquinoline derivatives 8. The condensation of 8 with hydrazine derivatives afforded the hydrazines 10a, and b. Also, hydrazones gave the corresponding arylidines 12a, and b on treatment with aldehydes 11. The antibacterial activity of the synthesized compounds was tested against four different bacterial species. The tested compounds showed moderate to potent antibacterial activity.. KEYWORDS :Antibacterial, Chalcones, Pyranouinolines, Pyrazolines chromones.
Type of Medium:
Online Resource
ISSN:
0971-1627
,
2456-4311
DOI:
10.59467/IJHC.2023.33.405
Language:
Unknown
Publisher:
Connect Journals
Publication Date:
2023
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