In:
PLOS ONE, Public Library of Science (PLoS), Vol. 15, No. 12 ( 2020-12-28), p. e0243826-
Abstract:
Recent studies suggest that occupational inhalant exposures trigger exacerbations of asthma and chronic obstructive pulmonary disease, but findings are conflicting. Methods We included 7,768 individuals with self-reported asthma (n = 3,215) and/or spirometric airflow limitation (forced expiratory volume in 1 second (FEV 1 )/ forced expiratory volume (FVC) 〈 0.70) (n = 5,275) who participated in The Copenhagen City Heart Study or The Copenhagen General Population Study from 2001–2016. Occupational exposure was assigned by linking job codes with job exposure matrices, and exacerbations were defined by register data on oral corticosteroid treatment, emergency care unit assessment or hospital admission. Associations between occupational inhalant exposure each year of follow-up and exacerbation were assessed by Cox regression with time varying exposure and age as the underlying time scale. Results Participants were followed for a median of 4.6 years (interquartile range, IQR 5.4), during which 870 exacerbations occurred. Exacerbations were not associated with any of the selected exposures (high molecular weight sensitizers, low molecular weight sensitizers, irritants or low and high levels of mineral dust, biological dust, gases & fumes or the composite variable vapours, gases, dusts or fumes). Hazards ratios ranged from 0.8 (95% confidence interval: 0.7;1.0) to 1.2 (95% confidence interval: 0.9;1.7). Conclusion Exacerbations of obstructive airway disease were not associated with occupational inhalant exposures assigned by a job exposure matrix. Further studies with alternative exposure assessment are warranted.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0243826
DOI:
10.1371/journal.pone.0243826.t001
DOI:
10.1371/journal.pone.0243826.t002
DOI:
10.1371/journal.pone.0243826.t003
DOI:
10.1371/journal.pone.0243826.s001
DOI:
10.1371/journal.pone.0243826.s002
DOI:
10.1371/journal.pone.0243826.s003
DOI:
10.1371/journal.pone.0243826.s004
DOI:
10.1371/journal.pone.0243826.s005
DOI:
10.1371/journal.pone.0243826.s006
DOI:
10.1371/journal.pone.0243826.s007
DOI:
10.1371/journal.pone.0243826.r001
DOI:
10.1371/journal.pone.0243826.r002
DOI:
10.1371/journal.pone.0243826.r003
DOI:
10.1371/journal.pone.0243826.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2020
detail.hit.zdb_id:
2267670-3
Permalink