In:
Acta Haematologica, S. Karger AG, Vol. 133, No. 2 ( 2015), p. 237-241
Abstract:
The presence of a Philadelphia chromosome with a corresponding 〈 i 〉 BCR-ABL1 〈 /i 〉 rearrangement is the hallmark of chronic myeloid leukemia, but is considered a very rare event in de novo acute myeloid leukemia (AML). Here, we report the first case in which a dominant Philadelphia chromosome-positive subclone was detected upon relapse in a formerly Philadelphia chromosome-negative 〈 i 〉 MLL-AF6 〈 /i 〉 〈 sup 〉 〈 i 〉 + 〈 /i 〉 〈 /sup 〉 AML. Due to refractory disease under salvage chemotherapy, the patient was started on nilotinib treatment. As a result, the Philadelphia chromosome-positive subclone was eradicated within 1 month; however, disease progressed and was again dominated by the Philadelphia chromosome-negative founding clone, demonstrating rapid clonal expansion under nilotinib-induced selection pressure. © 2014 S. Karger AG, Basel
Type of Medium:
Online Resource
ISSN:
0001-5792
,
1421-9662
Language:
English
Publisher:
S. Karger AG
Publication Date:
2015
detail.hit.zdb_id:
1481888-7
detail.hit.zdb_id:
80008-9
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