In:
Anaesthesia and Intensive Care, SAGE Publications, Vol. 33, No. 4 ( 2005-08), p. 483-491
Abstract:
The objective of this study was to evaluate a non-volitional measurement to assess diaphragmatic function in intubated and mechanically ventilated patients in a prospective pilot interventional clinical trial. The study was conducted in an 18-bed postoperative intensive care unit based at a university hospital. Patients were prospectively assigned to two groups. Group 1 consisted of eight patients with ventilator weaning failure. Group 2 consisted of eight intubated and ventilated patients who were studied shortly after major surgery and were successfully extubated thereafter. The twitch pressure response after cervical magnetic stimulation of the phrenic nerves was measured at the endotracheal tube at different PEEP levels. In group 2 the twitch transdiaphragmatic pressure, defined as the difference between twitch gastric and twitch oesophageal pressure was also evaluated. In group 1 the mean twitch pressure at the endotracheal tube on PEEP 0, 5 and 10 cmH 2 O was 5.2, 4.5 and 2.6 cmH 2 O: In group 2 this was significantly higher (15.1 cmH 2 O on PEEP 0 and 12.2 cmH 2 O on PEEP 5). A good correlation was found between twitch diaphragmatic pressure and twitch pressure at the endotracheal tube (r 2 =0.96) and between twitch oesophageal pressure and twitch pressure at the endotracheal tube (r 2 =0.98). Patients with weaning failure have significantly lower twitch pressure at the endotracheal tube suggesting diaphragmatic dysfunction. Twitch pressure at the endotracheal tube may be a useful parameter to screen for diaphragmatic dysfunction in intubated critically ill patients. Further studies are needed to confirm these preliminary findings.
Type of Medium:
Online Resource
ISSN:
0310-057X
,
1448-0271
DOI:
10.1177/0310057X0503300410
Language:
English
Publisher:
SAGE Publications
Publication Date:
2005
detail.hit.zdb_id:
2053705-0
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