In:
European Addiction Research, S. Karger AG, Vol. 27, No. 5 ( 2021), p. 371-380
Abstract:
〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Research on quality of life (QoL) of chronically ill patients provides an opportunity to evaluate the efficacy of long-term treatments. Although it is established that opioid replacement therapy is an effective treatment for opioid-dependent patients, there is little knowledge about physical and psychological functioning of QoL for different treatment options. 〈 b 〉 〈 i 〉 Objectives: 〈 /i 〉 〈 /b 〉 Altogether, 248 opioid-dependent patients receiving substitution treatment with either methadone/levomethadone ( 〈 i 〉 n 〈 /i 〉 = 126), diamorphine ( 〈 i 〉 n 〈 /i 〉 = 85), or buprenorphine ( 〈 i 〉 n 〈 /i 〉 = 37) were recruited in 6 German therapy centers. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Sociodemographic data were collected. QoL – physical and psychological functioning – for different substitutes was assessed using the 〈 i 〉 Profile of the Quality of Life in the Chronically Ill 〈 /i 〉 (PLC) questionnaire. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Patient groups were similar regarding age and duration of opioid dependence. Employment rate was significantly higher ( 〈 i 〉 p 〈 /i 〉 & #x3c; 0.005, φ = 0.22) in the buprenorphine group (46%) compared to methadone (18%). Dosage adjustments were more frequent ( 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001, φ = 0.29) in diamorphine (55%) than in methadone (30%) or buprenorphine (19%) patients. Buprenorphine and diamorphine patients rated their physical functioning substantially higher than methadone patients ( 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001, η 〈 sup 〉 2 〈 /sup 〉 = 0.141). Diamorphine patients reported a higher psychological functioning ( 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001, η 〈 sup 〉 2 〈 /sup 〉 = 0.078) and overall life improvement ( 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001, η 〈 sup 〉 2 〈 /sup 〉 = 0.060) compared to methadone, but not compared to buprenorphine patients (both 〈 i 〉 p 〈 /i 〉 & #x3e; 0.25). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Measurement of important QoL aspects indicates significant differences for physical and psychological functioning in patients receiving the substitutes methadone/levomethadone, diamorphine, and buprenorphine. This could be relevant for the differential therapy of opioid addiction.
Type of Medium:
Online Resource
ISSN:
1022-6877
,
1421-9891
Language:
English
Publisher:
S. Karger AG
Publication Date:
2021
detail.hit.zdb_id:
1482231-3
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