In:
The FASEB Journal, Wiley, Vol. 14, No. 14 ( 2000-11), p. 2284-2290
Abstract:
Exposure of B‐lineage lymphoid cells to a 100 μΤ 60 Hz AC magnetic field has been reported to stimulate the rapid activation of Lyn and Syk tyrosine kinases and the induction of protein tyrosine phosphorylation. These findings are significant because of the critical role played by these B cell signaling events in the control of growth and differentiation, and therefore the potential of electromagnetic field (EMF) exposure to induce cancer. We report the first study carried out with the aim of reproducing the reported EMF effects on Lyn and Syk tyrosine kinases. The system used enabled EMF exposure conditions to be carefully controlled and also allowed experiments to be performed blind. The effects of a 100 μT 60 Hz AC magnetic field on protein tyrosine phosphorylation and on Lyn and Syk tyrosine kinase activities were investigated in Nalm‐6 and DT40 B cells in the absence and presence of a 46 μT DC magnetic field. However, no significant effects of low‐energy electromagnetic fields on tyrosine kinase activities or protein phosphorylation were observed.—Woods, M., Bobanovic, F., Brown, D., Alexander, D. R. Lyn and Syk tyrosine kinases are not activated in B‐lineage lymphoid cells exposed to low‐energy electromagnetic fields. FASEB J. 14, 2284‐2290 (2000)
Type of Medium:
Online Resource
ISSN:
0892-6638
,
1530-6860
DOI:
10.1096/fj.00-0164com
Language:
English
Publisher:
Wiley
Publication Date:
2000
detail.hit.zdb_id:
1468876-1
SSG:
12
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